{{Rsnum
|rsid=78378222
|Gene=TP53
|Chromosome=17
|position=7668434
|Orientation=minus
|GMAF=0.00551
|Assembly=GRCh38
|GenomeBuild=38.1
|dbSNPBuild=141
|geno1=(A;A)
|geno2=(A;C)
|geno3=(C;C)
|Gene_s=TP53
}}{{doi|10.1038/ng.926}} rs78378222[C] (odds ratio (OR) = 2.36, P = 5.2 × 10?17). rs78378222 is in the 3? untranslated region of TP53 and changes the AATAAA polyadenylation signal to AATACA, resulting in impaired 3?-end processing of TP53 mRNA. Investigation of other tumor types identified associations of this SNP with [[prostate cancer]] (OR = 1.44, P = 2.4 × 10?6), [[glioma]] (OR = 2.35, P = 1.0 × 10?5) and colorectal adenoma (OR = 1.39, P = 1.6 × 10?4). However, we observed no effect for breast cancer, a common Li-Fraumeni syndrome tumor (OR = 1.06, P = 0.57, 95% confidence interval 0.88–1.27).
{{PMID Auto
|PMID=21946351
|Title=A germline variant in the TP53 polyadenylation signal confers cancer susceptibility
|OA=1
}}
{{PMID Auto
|PMID=22706378
|Title=Rare TP53 genetic variant associated with glioma risk and outcome
|OA=1
}}
{{PMID Auto
|PMID=23571737
|Title=Low penetrance susceptibility to glioma is caused by the TP53 variant rs78378222
}}
{{PMID Auto
|PMID=23742673
|Title=Association between a rare novel TP53 variant (rs78378222) and melanoma, squamous cell carcinoma of head and neck and lung cancer susceptibility in non-Hispanic Whites
}}{{PMID Auto
|PMID=22800615
|Title=A functional germline variant in the P53 polyadenylation signal and risk of esophageal squamous cell carcinoma.
}}