{{Rsnum
|rsid=7895676
|Gene=FGFR2
|Chromosome=10
|position=123333997
|Orientation=plus
|GMAF=0.376
|Assembly=GRCh37
|GenomeBuild=37.1
|dbSNPBuild=131
|geno1=(C;C)
|geno2=(C;T)
|geno3=(T;T)
}}
[[rs7895676]] is a SNP within intron 2 of the [[FGFR2]] gene, as part of a haplotype associated with increased risk for sporadic postmenopausal ER+ [[breast cancer]] in Caucasian patients. The risk shown for this SNP is actually the risk calculated for the tightly associated SNP [[rs1219648]].{{PMID|17529973|OA=1
}}

The distinguishing feature of [[rs7895676]] is experimental evidence indicating that it is one of two SNPs in this intron that appear to have a (the?) functional role associated with the transcriptional regulation of the [[FGFR2]] gene. The minor alleles of both SNPs, [[rs7895676]] and [[rs2981578]], lead to increased transcription and increased [[breast cancer]] risk.{{doi|10.1371/journal.pbio.0060108}}
{{ neighbor
| rsid = 11200014
| distance = 933
}}

{{PMID Auto
|PMID=19536173
|Title=Association of FGFR2 gene polymorphisms with the risk of breast cancer in population of West Siberia
|OA=1
}}

{{PharmGKB
|RSID=rs7895676
|Name_s=
|Gene_s=FGFR2
|Feature=
|Evidence=PubMed ID:19536173
|Annotation=The C allele of this variant was significantly associated with breast cancer risk in a study of the Russian population of 766 case and 665 control women from Siberia, Russian Federation. odds ratio (OR)=1.28 (1.12-1.43), P=1.7 x 10(-3).
|Drugs=
|Drug Classes=
|Diseases=Breast Neoplasms
|Curation Level=Curated
|PharmGKB Accession ID=PA164918233
}}

{{PMID|18462018|OA=1
}} Allele-specific up-regulation of FGFR2 increases susceptibility to breast cancer.

{{PMID|19223389|OA=1
}} FGFR2 variants and breast cancer risk: fine-scale mapping using African American studies and analysis of chromatin conformation.

{{PMID|19434427|OA=1
}} Analytical methods for inferring functional effects of single base pair substitutions in human cancers.

{{PMID|19497954|OA=1
}} Histone-acetylated control of fibroblast growth factor receptor 2 intron 2 polymorphisms and isoform splicing in breast cancer.

{{GET Evidence
|impact=pharmacogenetic
|qualified_impact=Insufficiently evaluated pharmacogenetic
|inheritance=unknown
|quality_scores=Array
|dbsnp_id=rs7895676
|overall_frequency_n=28
|overall_frequency_d=78
|overall_frequency=0.358974
|n_genomes=16
|n_genomes_annotated=0
|n_haplomes=23
|n_articles=1
|n_articles_annotated=0
|in_pharmgkb=Y
|autoscore=1
|webscore=N
}}

{{on chip | 23andMe v3}}
{{on chip | HumanOmni1Quad}}