{{Rsnum
|rsid=7900194
|Gene=CYP2C9
|Chromosome=10
|position=96702066
|Orientation=plus
|ReferenceAllele=G
|MissenseAllele=A
|GMAF=0.0124
|Assembly=GRCh37
|GenomeBuild=37.1
|dbSNPBuild=131
|geno1=(A;A)
|geno2=(A;G)
|geno3=(G;G)
}}
[[rs7900194]], also known as 449G>A, 3627G>A or R150H, is a SNP in the [[CYP2C9]] gene.

The [[rs7900194]](A) allele defines the CYP2C9*8 variant, which has decreased activity.

According to [https://www.23andme.com/you/community/thread/1144/ a 23andMe discussion] This is one of the SNPs which were re-analyzed April 2009. Customers with older data may wish to redownload. SNPs effected [[rs4420638]], [[rs34276300]], [[rs3091244]], [[rs34601266]], [[rs2033003]], [[rs7900194]], [[rs9332239]], [[rs28371685]], [[rs1229984]], and [[rs28399504]].

{{PharmGKB
|RSID=rs7900194
|Name_s=CYP2C9*8;CYP2C9:R150H
|Gene_s=CYP2C9
|Feature=Exon/NonSyn
|Evidence=PubMed ID:20072124
|Annotation=Phenotype: In African Americans patients, weekly warfarin dose requirements were lower in those with the CYP2C9*8 allele (34 (30-47) mg; P = 0.023) and the CYP2C9 *2, *3, *5, *6, or *11 allele (33(28-40 mg); P < 0.001) as compared with those with the CYP2C9*1/*1 genotype (43 (35-56) mg). Adding the *5,*6,*8 and *11 alleles to a model containing the *2 and *3 alleles plus the VKORC1 -1639 G>A allele (along with clinical variables) explained 36% vs. 30% of the variability in dose requirements. Study size: 226 . Study population/ethnicity: African-American . Type of association: PD;GN;CO
|Drugs=warfarin
|Drug Classes=
|Diseases=Atrial Fibrillation; Pulmonary Embolism; Stroke; Venous Thrombosis
|Curation Level=Curated
|PharmGKB Accession ID=PA165260363
}}

{{PMID Auto
|PMID=19663669
|Title=CYP2C9*8 is prevalent among African-Americans: implications for pharmacogenetic dosing.
|OA=1
}}

{{GET Evidence
|gene=CYP2C9
|aa_change=Arg150His
|aa_change_short=R150H
|impact=pharmacogenetic
|qualified_impact=Insufficiently evaluated pharmacogenetic
|inheritance=unknown
|quality_scores=Array
|dbsnp_id=rs7900194
|overall_frequency_n=218
|overall_frequency_d=10754
|overall_frequency=0.0202715
|n_genomes=3
|n_genomes_annotated=0
|n_haplomes=3
|n_articles=1
|n_articles_annotated=1
|in_pharmgkb=Y
|nblosum100=1
|autoscore=2
|webscore=N
}}

{{on chip | 23andMe v2}}
{{on chip | 23andMe v3}}
{{on chip | 23andMe v4}}