{{Rsnum
|rsid=7901695
|Gene=TCF7L2
|Chromosome=10
|position=114754088
|Orientation=plus
|GMAF=0.2658
|Assembly=GRCh37
|GenomeBuild=37.1
|dbSNPBuild=131
|geno1=(C;C)
|geno2=(C;T)
|geno3=(T;T)
}}
{{ population diversity
| geno1=(C;C)
| geno2=(C;T)
| geno3=(T;T)
| CEU | 10.7 | 34.8 | 54.5
| HCB | 0.0 | 5.1 | 94.9
| JPT | 0.9 | 5.3 | 93.8
| YRI | 19.0 | 53.1 | 27.9
| ASW | 24.6 | 49.1 | 26.3
| CHB | 0.0 | 5.1 | 94.9
| CHD | 0.0 | 7.3 | 92.7
| GIH | 6.9 | 43.6 | 49.5
| LWK | 21.1 | 54.1 | 24.8
| MEX | 10.3 | 36.2 | 53.4
| MKK | 16.8 | 45.8 | 37.4
| TSI | 14.7 | 42.2 | 43.1
| HapMapRevision=28
}}
{{PMID|17668382|OA=1
}} implicated in [[type-2 diabetes]] according to this [http://thegenesherpa.blogspot.com/2007/08/tcf7l2-strikes-again-this-time-its.html Gene Sherpas post]

Extensive [http://ongenetics.blogspot.com/2009/01/does-rs7901695-c-variant-predispose-to.html blog] post theorizing this snp may activate a cryptic exon.

{{PMID Auto
|PMID=19056611
|Title=Adiposity-related heterogeneity in patterns of type 2 diabetes susceptibility observed in genome-wide association data
|OA=1
}}

{{PMID Auto GWAS
|PMID=17463249
|Trait=Type 2 diabetes
|Title=Replication of genome-wide association signals in UK samples reveals risk loci for type 2 diabetes
|RiskAllele=C
|Pval=9.9999999999999997E-49
|OR=1.37
|ORtxt=[1.31-1.43]
|OA=1
}}

{{omim
|desc=TRANSCRIPTION FACTOR 7-LIKE 2; TCF7L2
|id=602228
|rsnum=7901695
}}

{{PMID Auto GWAS
|PMID=21347282
|Trait=None
|Title=Genome-Wide Association Study of Coronary Heart Disease and Its Risk Factors in 8,090 African Americans: The NHLBI CARe Project
|RiskAllele=
|Pval=0.000001
|OR=1.1900
|ORtxt=[1.11-1.28]
|OA=1
}}

{{PMID Auto
|PMID=22402060
|Title=Functional analysis of TCF7L2 genetic variants associated with type 2 diabetes
|OA=1
}}

{{PMID Auto
|PMID=22441719
|Title=Stronger Association of Common Variants in TCF7L2 Gene with Nonobese Type 2 Diabetes in the Latvian Population
}}

{{PMID Auto
|PMID=22584884
|Title=The Effect of Type 2 Diabetes Risk Loci on Insulin Requirements in Type 1 Diabetes
}}

{{PMID Auto
|PMID=15047616
|Title=A role for the malonyl-CoA/long-chain acyl-CoA pathway of lipid signaling in the regulation of insulin secretion in response to both fuel and nonfuel stimuli
}}

{{PMID|16936218}} Polymorphisms in the transcription factor 7-like 2 (TCF7L2) gene are associated with type 2 diabetes in the Amish: replication and evidence for a role in both insulin secretion and insulin resistance.

{{PMID|17245407}} TCF7L2 polymorphisms are associated with type 2 diabetes in northern Sweden.

{{PMID|17245589}} A genetic variation of the transcription factor 7-like 2 gene is associated with risk of type 2 diabetes in the Japanese population.

{{PMID|17311858}} TCF7L2 gene polymorphisms confer an increased risk for early impairment of glucose metabolism and increased height in obese children.

{{PMID|17340123}} Replication study for the association of TCF7L2 with susceptibility to type 2 diabetes in a Japanese population.

{{PMID|17601994}} Variants of the transcription factor 7-like 2 (TCF7L2) gene are associated with type 2 diabetes in an African-American population enriched for nephropathy.

{{PMID|17661009|OA=1
}} Impaired glucagon-like peptide-1-induced insulin secretion in carriers of transcription factor 7-like 2 (TCF7L2) gene polymorphisms.

{{PMID|17786212|OA=1
}} Heterogeneity in meta-analyses of genome-wide association investigations.

{{PMID|17934151}} A variant of the transcription factor 7-like 2 (TCF7L2) gene and the risk of posttransplantation diabetes mellitus in renal allograft recipients.

{{PMID|17971425|OA=1
}} Association of TCF7L2 gene polymorphisms with reduced acute insulin response in Hispanic Americans.

{{PMID|18268068|OA=1
}} Variation in TCF7L2 and increased risk of colon cancer: the Atherosclerosis Risk in Communities (ARIC) Study.

{{PMID|18291022|OA=1
}} Common variants of the TCF7L2 gene are associated with increased risk of type 2 diabetes mellitus in a UK-resident South Asian population.

{{PMID|18437354|OA=1
}} TCF7L2 single nucleotide polymorphisms, cardiovascular disease and all-cause mortality: the Atherosclerosis Risk in Communities (ARIC) study.

{{PMID|18469204|OA=1
}} Implication of genetic variants near TCF7L2, SLC30A8, HHEX, CDKAL1, CDKN2A/B, IGF2BP2, and FTO in type 2 diabetes and obesity in 6,719 Asians.

{{PMID|18533027|OA=1
}} Worldwide population differentiation at disease-associated SNPs.

{{PMID|18591388|OA=1
}} Assessing the combined impact of 18 common genetic variants of modest effect sizes on type 2 diabetes risk.

{{PMID|18650481|OA=1
}} TCF7L2 variants associate with CKD progression and renal function in population-based cohorts.

{{PMID|18655717|OA=1
}} Weak or no association of TCF7L2 variants with Type 2 diabetes risk in an Arab population.

{{PMID|18712344}} Association of variants of the TCF7L2 gene with increases in the risk of type 2 diabetes and the proinsulin:insulin ratio in the Spanish population.

{{PMID|18780302|OA=1
}} Association studies of 22 candidate SNPs with late-onset Alzheimer's disease.

{{PMID|19050058|OA=1
}} Single nucleotide transcription factor 7-like 2 (TCF7L2) gene polymorphisms in antiislet autoantibody-negative patients at onset of diabetes.

{{PMID|19053027}} Loci of TCF7L2, HHEX and IDE on chromosome 10q and the susceptibility of their genetic polymorphisms to type 2 diabetes.

{{PMID|19096518|OA=1
}} Novel association of HK1 with glycated hemoglobin in a non-diabetic population: a genome-wide evaluation of 14,618 participants in the Women's Genome Health Study.

{{PMID|19161620|OA=1
}} An open access database of genome-wide association results.

{{PMID|19207020|OA=1
}} Meta-analysis in genome-wide association studies.

{{PMID|19228405|OA=1
}} Association between TCF7L2 gene polymorphisms and susceptibility to type 2 diabetes mellitus: a large Human Genome Epidemiology (HuGE) review and meta-analysis.

{{PMID|19323962|OA=1
}} Genome-wide association studies in type 2 diabetes.

{{PMID|19463184|OA=1
}} Worldwide patterns of haplotype diversity at 9p21.3, a locus associated with type 2 diabetes and coronary heart disease.

{{PMID|19526209|OA=1
}} Is the thrifty genotype hypothesis supported by evidence based on confirmed type 2 diabetes- and obesity-susceptibility variants?

{{PMID|19602701|OA=1
}} Underlying genetic models of inheritance in established type 2 diabetes associations.

{{PMID|19750184|OA=1
}} Genome-wide association studies for atherosclerotic vascular disease and its risk factors.

{{PMID|19913122|OA=1
}} ATRIUM: testing untyped SNPs in case-control association studies with related individuals.

{{PMID|19924244|OA=1
}} TCF7L2 polymorphism rs7903146 is associated with coronary artery disease severity and mortality.

{{PMID|19931040|OA=1
}} Simultaneous genotype calling and haplotype phasing improves genotype accuracy and reduces false-positive associations for genome-wide association studies.

{{PMID|20017978|OA=1
}} Influence of control selection in genome-wide association studies: the example of diabetes in the Framingham Heart Study.

{{PMID|20075150|OA=1
}} Utility of genetic and non-genetic risk factors in prediction of type 2 diabetes: Whitehall II prospective cohort study.

{{PMID|20144327|OA=1
}} A genomics study of type 2 diabetes mellitus in U.S. Air Force personnel.

{{PMID|21159844}} Variants and haplotypes of TCF7L2 are associated with beta-cell function in patients with newly diagnosed type 2 diabetes: the Verona Newly Diagnosed Type 2 Diabetes Study (VNDS) 1.

{{PMID|21278902|OA=1
}} Genetic risk profiling for prediction of type 2 diabetes.

{{PMID|21672010|OA=1
}} Gestational diabetes mellitus is associated with TCF7L2 gene polymorphisms independent of HLA-DQB1*0602 genotypes and islet cell autoantibodies.

{{PMID|21898192}} Worldwide distribution of type II diabetes-associated TCF7L2 SNPs: evidence for stratification in Europe.

{{PMID|22377712}} Association between type 2 diabetes genetic susceptibility loci and visceral and subcutaneous fat area as determined by computed tomography.

{{GET Evidence
|impact=pathogenic
|qualified_impact=Insufficiently evaluated pathogenic
|inheritance=unknown
|quality_scores=Array
|dbsnp_id=rs7901695
|overall_frequency_n=38
|overall_frequency_d=128
|overall_frequency=0.296875
|n_genomes=28
|n_genomes_annotated=0
|n_haplomes=36
|n_articles=0
|n_articles_annotated=0
|in_gwas=Y
|autoscore=1
|webscore=N
}}

{{PMID Auto
|PMID=23188737
|Title=TCF7L2 gene polymorphisms and type 2 diabetes risk: a comprehensive and updated meta-analysis involving 121,174 subjects
}}

{{PMID Auto
|PMID=22480428
|Title=T2D risk haplotypes of the TCF7L2 gene in the Czech population sample: the association with free fatty acids composition.
}}

{{PMID Auto
|PMID=22843023
|Title=TCF7L2 gene polymorphisms and type 2 diabetes: association with diabetic retinopathy and cardiovascular autonomic neuropathy.
}}

{{PMID Auto
|PMID=23107111
|Title=Transcription factor-7-like 2 gene variants are strongly associated with type 2 diabetes in Lebanese subjects.
}}

{{PMID Auto
|PMID=23456907
|Title=Maternal genotype and gestational diabetes.
}}

{{PMID Auto
|PMID=23462794
|Title=Identification of CpG-SNPs associated with type 2 diabetes and differential DNA methylation in human pancreatic islets.
|OA=1
}}

{{on chip | 23andMe v1}}
{{on chip | 23andMe v2}}
{{on chip | 23andMe v3}}
{{on chip | 23andMe v4}}
{{on chip | Affy GenomeWide 6}}
{{on chip | HumanOmni1Quad}}
{{on chip | Illumina Human 1M}}