{{Rsnum
|rsid=7903146
|Gene=TCF7L2
|Chromosome=10
|position=112998590
|Orientation=plus
|GMAF=0.2181
|Assembly=GRCh38
|GenomeBuild=38.1
|dbSNPBuild=141
|Summary=Associated with T2D.
|geno1=(C;C)
|geno2=(C;T)
|geno3=(T;T)
|Gene_s=TCF7L2
}}{{ population diversity
| geno1=(C;C)
| geno2=(C;T)
| geno3=(T;T)
| CEU | 54.9 | 34.5 | 10.6
| HCB | 94.9 | 5.1 | 0.0
| JPT | 93.8 | 5.3 | 0.9
| YRI | 51.7 | 42.9 | 5.4
| ASW | 41.1 | 50.0 | 8.9
| CHB | 94.9 | 5.1 | 0.0
| CHD | 92.7 | 7.3 | 0.0
| GIH | 51.5 | 41.6 | 6.9
| LWK | 52.7 | 39.1 | 8.2
| MEX | 55.2 | 37.9 | 6.9
| MKK | 49.4 | 40.4 | 10.3
| TSI | 43.1 | 41.2 | 15.7
| HapMapRevision=28
}}This [[SNP]] in [[TCF7L2]] influences the risk of [[Type-2 diabetes]] ([[T2D]]). This SNP is also known as IVS3C>T.

{{PMID|17671651|OA=1
}} [[rs7903146(C;T)]] [[rs7903146(T;T)]] strongly predicted future [[type-2 diabetes]]. Considered in context with [[rs7903146]] [[rs12255372]] [[rs10885406]]. 

Note: this is one of two SNPs within the [[TCF7L2]] gene that have been reported to be associated with [[type-2 diabetes]], the other being [[rs4506565]]. They have approximately equal power to estimate risk for [[type-2 diabetes]], and the results from one correlate 92% of the time with the other. {{PMID|17554300|OA=1
}}

[http://medicine.plosjournals.org/perlserv/request=get-documentamp?request=get-document&doi=10.1371/journal.pmed.0030374 Full text of the paper] is available from from Plos Medicine. 

Or from NCBI as {{PMID|17020404|OA=1
}}.
 
{{PMID|16855264|OA=1
}} [[TCF7L2]] polymorphisms and progression to diabetes in the Diabetes Prevention Program.

{{PMID|17668382|OA=1
}} reconfirmed in a diverse population

{{PMID|17971425|OA=1
}} Associated in a study of ~1000 Hispanic-Americans with reduced insulin secretion as measured by acute insulin response and adjusted for the degree of insulin sensitivity (p = 0.032).

{{PMID|17671651|OA=1
}} the CT/TT genotypes strongly predicted future [[type-2 diabetes]]. The risk T allele was associated with impaired insulin secretion, incretin effects, and enhanced rate of hepatic glucose production. TCF7L2 expression in human islets was increased 5-fold in T2D, particularly in carriers of the TT genotype.

This SNP is one of 4 relatively common SNPs reported to represent risk for [[type-2 diabetes]] in the DESIR prospective study of 3,877 Caucasian participants. Under an additive model, the odds ratio for the (T) risk allele is 1.45 (CI: 1.2-1.77, p=0.0002). For the 4 SNPs, each risk allele increased [[type-2 diabetes]] risk by 1.34x (p=2x10e-6), with an odds ratio of 2.48 (CI: 1.59-3.86) for carriers of 4 or more compared to those with one or none (risk alleles).{{PMID|17977958}}

Contrary to what's been seen in most populations studied so far, the association between [[rs7903146]] and [[type-2 diabetes]] apparently does not hold in Arab populations, based on a case-control study of 522 Saudi patients and 346 controls.{{PMID|18655717|OA=1
}}

A HuGE review and meta-analysis including over 35,000 type-2 diabetes cases and 39,000 controls concluded that the Bayesian odds ratio for [[rs7903146]](T;T) homozygotes and (C;T) heterozygotes versus (C;C) homozygotes was 1.968 (95% credible interval (CrI): 1.790 - 2.157) and 1.406 (95% CrI: 1.341 - 1.476), respectively, and the population attributable risk (PAR) for the (C;T)/(T;T) genotypes of this variant is 16.9% overall. Along with 3 other [[TCF7L2]] SNPs, a multiplicative genetic model was indicated.{{PMID|19228405|OA=1
}}

A study of over 13,000 individuals initially free of [[cancer]] and followed over 10+ years found that the [[rs7903146]](T) allele was associated with increased risk of [[colorectal cancer]], with an adjusted odds ratio of  1.25 (CI:0.85-1.83) and 2.15 (CI:1.27-3.64) for the (C;T) and (T;T) genotypes, respectively.{{PMID|18268068|OA=1
}}

Does the association with type 2 diabetes hold for youth as well as for [[ageing|adults]]?  Among [[African American]] youth, each copy of a rs7903146(T) allele was associated with a 1.97-fold (CI:1.37 - 2.82) increased odds for [[type 2 diabetes]] (p?<?0.0001), yet no significant association was detected in non-Hispanic white youth (adjusted odds ratio 1.14; CI: 0.73 - 1.79).{{PMID|21109996|OA=1
}}

{{PMID Auto
|PMID=19258437
|Title=A Genetic Variant in the IGF2BP2 Gene may Interact with Fetal Malnutrition on Glucose Metabolism.
|OA=1
}}

{{PMID Auto
|PMID=18555673
|Title=The effect of WNT5B IVS3C&gt;G on the susceptibility to type 2 diabetes in UK Caucasian subjects
}}
{{PMID Auto GWAS
|PMID=19056611
|Trait=Type 2 diabetes
|Title=Adiposity-related heterogeneity in patterns of type 2 diabetes susceptibility observed in genome wide association data
|RiskAllele=
|Pval=9E-30
|OR=1.49
|ORtxt=[1.39-1.59]
|OA=1
}}
{{PMID Auto GWAS
|PMID=18372903
|Trait=Type 2 diabetes
|Title=Meta-analysis of genome-wide association data and large-scale replication identifies additional susceptibility loci for type 2 diabetes
|RiskAllele=T
|Pval=3E-23
|OR=1.37
|ORtxt=[1.28-1.47]
|OA=1
}}
{{PMID Auto GWAS
|PMID=17463246
|Trait=Type 2 diabetes
|Title=Genome-wide association analysis identifies loci for type 2 diabetes and triglyceride levels
|RiskAllele=T
|Pval=9.9999999999999997E-49
|OR=1.37
|ORtxt=[1.31-1.43]
}}
{{PMID Auto GWAS
|PMID=17463248
|Trait=Type 2 diabetes
|Title=A genome-wide association study of type 2 diabetes in Finns detects multiple susceptibility variants
|RiskAllele=T
|Pval=9.9999999999999997E-49
|OR=1.37
|ORtxt=[1.31-1.43]
|OA=1
}}
{{PMID Auto GWAS
|PMID=17460697
|Trait=Type 2 diabetes
|Title=A variant in CDKAL1 influences insulin response and risk of type 2 diabetes
|RiskAllele=
|Pval=2.0000000000000001E-10
|OR=1.38
|ORtxt=[NR]
}}
{{PMID Auto GWAS
|PMID=17293876
|Trait=Type 2 diabetes
|Title=A genome-wide association study identifies novel risk loci for type 2 diabetes
|RiskAllele=T
|Pval=1.9999999999999999E-34
|OR=1.65
|ORtxt=[1.28, 2.02]
}}
{{PMID Auto GWAS
|PMID=19401414
|Trait=Type 2 diabetes
|Title=Confirmation of multiple risk loci and genetic impacts by a genome-wide association study of type 2 diabetes in the Japanese population
|RiskAllele=T
|Pval=8E-12
|OR=1.54
|ORtxt=[1.36-1.74]
|OA=1
}}
{{PMID Auto
|PMID=18972257
|Title=Comparison of genetic risk in three candidate genes (TCF7L2, PPARG, KCNJ11) with traditional risk factors for type 2 diabetes in a population-based study--the HUNT study
}}
{{PMID Auto
|PMID=18996470
|Title=Rapid and cost effective genotyping method for polymorphisms in PPARG, PPARGC1 and TCF7L2 genes
}}
{{PMID Auto
|PMID=19473183
|Title=Interactions between TCF7L2 genotype and growth hormone-induced changes in glucose homeostasis in small for gestational age children
}}
{{PMID Auto
|PMID=19509102
|Title=Genetic Variants of TCF7L2 are Associated with Insulin Resistance and Related Metabolic Phenotypes in Taiwanese Adolescents and Caucasian Young Adults
}}
{{PMID Auto
|PMID=19533015
|Title=Transcription factor 7-like 2-gene polymorphism is related to fasting C peptide in latent autoimmune diabetes in adults (LADA)
}}

{{PMID Auto
|PMID=19183934
|Title=TCF7L2 variants are associated with increased proinsulin/insulin ratios but not obesity traits in the Framingham Heart Study
|OA=1
}}
{{PMID Auto
|PMID=19573884
|Title=No association between TCF7L2 rs7903146 and euglycemic-clamp-derived insulin sensitivity in a mixed-age cohort
|OA=1
}}
{{PMID Auto
|PMID=19585101
|Title=A susceptibility gene for type 2 diabetes confers substantial risk for diabetes complicating cystic fibrosis
|OA=1
}}

{{omim
|desc=DIABETES MELLITUS, NONINSULIN-DEPENDENT; NIDDM
|id=125853
|rsnum=7903146
}}

{{omim
|id=602228
|desc=TRANSCRIPTION FACTOR 7-LIKE 2; TCF7L2
|rsnum=7903146
}}
{{PMID Auto
|PMID=19713311
|Title=TCF7L2 Polymorphism Associates with New-Onset Diabetes after Transplantation
|OA=1
}}
{{PMID Auto GWAS
|PMID=19734900
|Trait=Type 2 diabetes and other traits
|Title=Genetic variant near IRS1 is associated with type 2 diabetes, insulin resistance and hyperinsulinemia
|RiskAllele=T
|Pval=1E-30
|OR=1.48
|ORtxt=[1.39-1.57]
}}
{{PMID Auto
|PMID=19864407
|Title=Effects of TCF7L2 polymorphisms on glucose values after a lifestyle intervention
}}

{{PMID Auto
|PMID=19924244
|Title=TCF7L2 Polymorphism rs7903146 Is Associated with Coronary Artery Disease Severity and Mortality
|OA=1
}}

{{PharmGKB
|RSID=rs7903146
|Name_s=
|Gene_s=TCF7L2
|Feature=
|Evidence=PubMed ID:17668382; Web Resource:http://www.genome.gov/gwastudies/
|Annotation=GWAS results: Type 2 diabetes whole-genome association study in four populations: the DiaGen consortium. (Initial Sample Size: 500 cases, 497 controls; Replication Sample Size: 2,573 cases, 2,776 controls); (Region: 10q25.2; Reported Gene(s): TCF7L2; Risk Allele: rs7903146-A); (p-value= 4.99999999999999E-08).This variant is associated with Type 2 diabetes.
|Drugs=
|Drug Classes=
|Diseases=Diabetes Mellitus; Diabetes Mellitus, Type 2
|Curation Level=Non-Curated
|PharmGKB Accession ID=PA164740864
}}
{{PMID Auto
|PMID=20028944
|Title=Gene variants of TCF7L2 influence weight loss and body composition during lifestyle intervention in a risk population for type 2 diabetes
|OA=1
}}
{{PMID Auto
|PMID=20041287
|Title=Polymorphisms of TCF7L2 and HHEX genes in Chinese women with polycystic ovary syndrome
|OA=1
}}
{{PMID Auto
|PMID=20043145
|Title=Improvements in glucose homeostasis in response to regular exercise are influenced by the PPARG Pro12Ala variant: results from the HERITAGE Family Study
|OA=1
}}

{{PMID Auto
|PMID=20097709
|Title=Genotype and tissue-specific effects on alternative splicing of the transcription factor 7-like 2 gene in humans
|OA=1
}}
{{PMID Auto
|PMID=20437825
|Title=Relationship of five type 2 diabetes candidate gene polymorphisms to the age at diagnosis of diabetes in the Slovakian population
}}
{{PMID Auto
|PMID=20503258
|Title=Candidate gene association study conditioning on individual ancestry in patients with type 2 diabetes and metabolic syndrome from Mexico City
}}
{{PMID Auto
|PMID=20546291
|Title=Association of TCF7L2 gene variants with low GAD autoantibody titre in LADA subjects (NIRAD Study 5)
}}
{{PMID Auto
|PMID=19806338
|Title=TCF7L2 genetic variants and progression to diabetes in the Chinese population: pleiotropic effects on insulin secretion and insulin resistance
}}
{{PMID Auto
|PMID=20578204
|Title=Transcription factor 7-like 2 (TCF7L2) polymorphism and context-specific risk of impaired fasting glucose in African American and Caucasian adults: the atherosclerosis risk in communities (ARIC) study
|OA=1
}}
{{PMID Auto
|PMID=20597906
|Title=A Validation Study of Type 2 Diabetes-related Variants of the TCF7L2, HHEX, KCNJ11, and ADIPOQ Genes in one Endogamous Ethnic Group of North India
}}
{{PMID Auto GWAS
|PMID=20581827
|Trait=Type 2 diabetes
|Title=Twelve type 2 diabetes susceptibility loci identified through large-scale association analysis
|RiskAllele=T
|Pval=2E-51
|OR=1.40
|ORtxt=[1.34-1.46]
|OA=1
}}
{{PMID Auto
|PMID=20682688
|Title=Hyperglycemia and Adverse Pregnancy Outcome (HAPO) Study: common genetic variants in GCK and TCF7L2 are associated with fasting and post-challenge glucose levels in pregnancy and with the new consensus definition of gestational diabetes from the International Association of Diabetes and Pregnancy Study Groups
|OA=1
}}
{{PMID Auto
|PMID=20802253
|Title=Glycemia determines the effect of type 2 diabetes risk genes on insulin secretion
|OA=1
}}
{{PMID Auto
|PMID=20839289
|Title=Impact of repeated measures and sample selection on genome-wide association studies of fasting glucose
|OA=1
}}
{{PMID Auto GWAS
|PMID=20694148
|Trait=None
|Title=A genome-wide association study of the metabolic syndrome in Indian Asian men
|RiskAllele=A
|Pval=7E-7
|OR=1.33
|ORtxt=[1.19-1.49]
|OA=1
}}
{{PMID Auto GWAS
|PMID=20849430
|Trait=None
|Title=The TCF7L2 Diabetes Risk Variant is Associated with HbA(1C) Levels: a Genome-Wide Association Meta-Analysis
|RiskAllele=C
|Pval=1E-7
|OR=0.05
|ORtxt=[0.02-0.08] % HbA1C decrease
}}
{{PMID Auto
|PMID=20980453
|Title=Re-sequencing and Analysis of Variation in the TCF7L2 Gene in African Americans Suggests the SNP rs7903146 is the Causal Diabetes Susceptibility Variant
|OA=1
}}

{{omim
|id=104210
|desc=ALPHA-2A-ADRENERGIC RECEPTOR; ADRA2A
|rsnum=7903146
}}

{{PharmGKB
|RSID=rs7903146
|Name_s=
|Gene_s=TCF7L2
|Feature=
|Evidence=PubMed ID:17463246
|Annotation=rs7903146 demonstrated association with Type 2 Diabetes in a GWAS of Finnish and Swedish patients and controls.
|Drugs=
|Drug Classes=
|Diseases=Diabetes Mellitus, Type 2
|Curation Level=Curated
|PharmGKB Accession ID=PA162168097
}}

{{PharmGKB
|RSID=rs7903146
|Name_s=
|Gene_s=TCF7L2
|Feature=
|Evidence=PubMed ID:17554300; PubMed ID:17671651; PubMed ID:18239663; PubMed ID:18264689
|Annotation=This variant has been reported to be significantly associated with type 2 diabetes in multiple studies, the CT/TT genotypes of rs7903146 strongly predicted future T2D.
|Drugs=
|Drug Classes=
|Diseases=Diabetes Mellitus, Type 2
|Curation Level=Curated
|PharmGKB Accession ID=PA161749009
}}

{{PharmGKB
|RSID=rs7903146
|Name_s=
|Gene_s=TCF7L2
|Feature=
|Evidence=PubMed ID:17463248
|Annotation=In a large Finnish case-control GWAS, rs7903146 was found to be associated with susceptibility to Type 2 Diabetes.
|Drugs=
|Drug Classes=
|Diseases=Diabetes Mellitus, Type 2
|Curation Level=Curated
|PharmGKB Accession ID=PA162191362
}}

{{PharmGKB
|RSID=rs7903146
|Name_s=
|Gene_s=TCF7L2
|Feature=
|Evidence=PubMed ID:18853134
|Annotation=In a large study of 16,143 non-diabetic individuals this SNP in the TCF7L2 gene predicted the development of at least two components of the metabolic syndrome.
|Drugs=
|Drug Classes=
|Diseases=Metabolic Diseases; Metabolic Syndrome X
|Curation Level=Curated
|PharmGKB Accession ID=PA162355882
}}

{{PharmGKB
|RSID=rs7903146
|Name_s=
|Gene_s=TCF7L2
|Feature=
|Evidence=PubMed ID:19141698
|Annotation=High (n-6) polyunsaturated fatty acids intakes were associated with atherogenic dyslipidemia in carriers of the minor T allele at this SNP in the TCF7L2 gene and may predispose them to MetS, diabetes, and cardiovascular disease.
|Drugs=
|Drug Classes=
|Diseases=Hyperlipidemias; metabolic syndrome
|Curation Level=Curated
|PharmGKB Accession ID=PA162370427
}}

{{PharmGKB
|RSID=rs7903146
|Name_s=
|Gene_s=TCF7L2
|Feature=
|Evidence=PubMed ID:19056611; Web Resource:http://www.genome.gov/gwastudies/
|Annotation=GWAS results: Adiposity-related heterogeneity in patterns of type 2 diabetes susceptibility observed in genome wide association data. (Initial Sample Size: 1,924 cases, 2,938 controls; Replication Sample Size: 3,757 cases, 5,346 controls); (Region: 10q25.2; Reported Gene(s): TCF7L2; Risk Allele: rs7903146-?); (p-value(obese)= 0.0000000000000006).This variant is associated with Type 2 diabetes.
|Drugs=
|Drug Classes=
|Diseases=Diabetes Mellitus; Diabetes Mellitus, Type 2
|Curation Level=Non-Curated
|PharmGKB Accession ID=PA164740296
}}

{{PharmGKB
|RSID=rs7903146
|Name_s=
|Gene_s=TCF7L2
|Feature=
|Evidence=PubMed ID:19056611; Web Resource:http://www.genome.gov/gwastudies/
|Annotation=GWAS results: Adiposity-related heterogeneity in patterns of type 2 diabetes susceptibility observed in genome wide association data. (Initial Sample Size: 1,924 cases, 2,938 controls; Replication Sample Size: 3,757 cases, 5,346 controls); (Region: 10q25.2; Reported Gene(s): TCF7L2; Risk Allele: rs7903146-?); (p-value(non-obese)= 9E-30).This variant is associated with Type 2 diabetes.
|Drugs=
|Drug Classes=
|Diseases=Diabetes Mellitus; Diabetes Mellitus, Type 2
|Curation Level=Non-Curated
|PharmGKB Accession ID=PA164740294
}}

{{PMID Auto
|PMID=21301999
|Title=Genetic variations in transcription factor 7-like 2 (TCF7L2) gene: association of TCF7L2 rs12255372(G/T) or rs7903146(C/T) with breast cancer risk and clinico-pathological parameters
}}

{{omim
|id=104210
|rsnum=7903146
|variant=0001
}}

{{omim
|id=602228
|rsnum=7903146
|variant=0001
}}

{{PMID Auto
|PMID=21414605
|Title=At-Risk Variant in TCF7L2 for Type II Diabetes Increases Risk of Schizophrenia
}}

{{PMID Auto
|PMID=21543200
|Title=Dietary saturated fat, gender and genetic variation at the TCF7L2 locus predict the development of metabolic syndrome
}}

{{PMID Auto
|PMID=21641671
|Title=Transcription factor 7-like 2 (TCF7L2) gene polymorphism and complication/comorbidity profile in type 2 diabetes patients
}}

{{PMID Auto
|PMID=21678030
|Title=Association of a common variant in TCF7L2 gene with type 2 diabetes mellitus in a Persian population
}}

{{PMID Auto
|PMID=22052079
|Title=Association analysis of 31 common polymorphisms with type 2 diabetes and its related traits in Indian sib pairs
|OA=1
}}

{{PMID Auto
|PMID=22109281
|Title=The type 2 diabetes-associated variant in TCF7L2 is associated with latent autoimmune diabetes in adult Europeans and the gene effect is modified by obesity: a meta-analysis and an individual study
}}

{{PMID Auto
|PMID=21749608
|Title=Genetic variants and the metabolic syndrome: a systematic review
}}

{{PMID Auto
|PMID=22275441
|Title=Genetic risk assessment of type 2 diabetes-associated polymorphisms in african americans
|OA=1
}}

{{PMID Auto GWAS
|PMID=22101970
|Trait=None
|Title=Use of diverse electronic medical record systems to identify genetic risk for type 2 diabetes within a genome-wide association study.
|RiskAllele=T
|Pval=2E-15
|OR=1.4600
|ORtxt=None
|OA=1
}}

{{PMID Auto GWAS
|PMID=21873549
|Trait=None
|Title=Genome-wide association identifies nine common variants associated with fasting proinsulin levels and provides new insights into the pathophysiology of type 2 diabetes.
|RiskAllele=T
|Pval=2E-20
|OR=None
|ORtxt=None
|OA=1
}}

{{PMID Auto
|PMID=22402060
|Title=Functional analysis of TCF7L2 genetic variants associated with type 2 diabetes
|OA=1
}}

{{PMID Auto
|PMID=22419714
|Title=Effect of Type 2 Diabetes Predisposing Genetic Variants on Colorectal Cancer Risk
}}

{{PMID Auto
|PMID=22441719
|Title=Stronger Association of Common Variants in TCF7L2 Gene with Nonobese Type 2 Diabetes in the Latvian Population
}}

{{PMID Auto
|PMID=22569928
|Title=Analysis of common type 2 diabetes mellitus genetic risk factors in new-onset diabetes after transplantation in kidney transplant patients medicated with tacrolimus
|OA=1
}}

{{PMID Auto
|PMID=22590553
|Title=An in vivo cis-Regulatory Screen at the Type 2 Diabetes Associated TCF7L2 Locus Identifies Multiple Tissue-Specific Enhancers
|OA=1
}}

{{PMID Auto
|PMID=21399856
|Title=Variants of transcription factor 7-like 2 (TCF7L2) gene and incident glucose intolerance in Japanese-Brazilians
}}

{{PMID Auto
|PMID=22712642
|Title=TCF7L2 polymorphism and cognitive test performance in cardiovascular disease
}}

{{PMID Auto
|PMID=16936215
|Title=Association analysis of 6,736 U.K. subjects provides replication and confirms TCF7L2 as a type 2 diabetes susceptibility gene with a substantial effect on individual risk.
}}

{{PMID Auto
|PMID=16936217
|Title=Association of transcription factor 7-like 2 (TCF7L2) variants with type 2 diabetes in a Finnish sample.
}}

{{PMID Auto
|PMID=16936218
|Title=Polymorphisms in the transcription factor 7-like 2 (TCF7L2) gene are associated with type 2 diabetes in the Amish: replication and evidence for a role in both insulin secretion and insulin resistance.
}}

{{PMID Auto
|PMID=17003358
|Title=Common single nucleotide polymorphisms in TCF7L2 are reproducibly associated with type 2 diabetes and reduce the insulin response to glucose in nondiabetic individuals.
}}

{{PMID Auto
|PMID=17003360
|Title=Transcription factor TCF7L2 genetic study in the French population: expression in human beta-cells and adipose tissue and strong association with type 2 diabetes.
}}

{{PMID Auto
|PMID=17031610
|Title=Association of variants of transcription factor 7-like 2 (TCF7L2) with susceptibility to type 2 diabetes in the Dutch Breda cohort.
}}

{{PMID Auto
|PMID=17065361
|Title=TCF7L2 variation predicts hyperglycemia incidence in a French general population: the data from an epidemiological study on the Insulin Resistance Syndrome (DESIR) study.
}}

{{PMID Auto
|PMID=17093941
|Title=Common variants in the TCF7L2 gene are strongly associated with type 2 diabetes mellitus in the Indian population.
}}

{{PMID Auto
|PMID=17130514
|Title=Polymorphism in the transcription factor 7-like 2 (TCF7L2) gene is associated with reduced insulin secretion in nondiabetic women.
}}

{{PMID Auto
|PMID=17181866
|Title=Effects of the diabetes linked TCF7L2 polymorphism in a representative older population.
|OA=1
}}

{{PMID Auto
|PMID=17206141
|Title=Refining the impact of TCF7L2 gene variants on type 2 diabetes and adaptive evolution.
}}

{{PMID Auto
|PMID=17226113
|Title=Variants of the transcription factor 7-like 2 gene (TCF7L2) are strongly associated with type 2 diabetes but not with the metabolic syndrome in the MONICA/KORA surveys.
}}

{{PMID Auto
|PMID=17245589
|Title=A genetic variation of the transcription factor 7-like 2 gene is associated with risk of type 2 diabetes in the Japanese population.
}}

{{PMID Auto
|PMID=17259383
|Title=Haplotypes of transcription factor 7-like 2 (TCF7L2) gene and its upstream region are associated with type 2 diabetes and age of onset in Mexican Americans.
}}

{{PMID Auto
|PMID=17311858
|Title=TCF7L2 gene polymorphisms confer an increased risk for early impairment of glucose metabolism and increased height in obese children.
}}

{{PMID Auto
|PMID=17340123
|Title=Replication study for the association of TCF7L2 with susceptibility to type 2 diabetes in a Japanese population.
}}

{{PMID Auto
|PMID=17342473
|Title=A variant in the transcription factor 7-like 2 (TCF7L2) gene is associated with an increased risk of gestational diabetes mellitus.
}}

{{PMID Auto
|PMID=17416797
|Title=TCF7L2 polymorphisms modulate proinsulin levels and beta-cell function in a British Europid population.
|OA=1
}}

{{PMID Auto
|PMID=17429603
|Title=TCF7L2 in the Go-DARTS study: evidence for a gene dose effect on both diabetes susceptibility and control of glucose levels.
}}

{{PMID Auto
|PMID=17437080
|Title=Variants of transcription factor 7-like 2 (TCF7L2) gene predict conversion to type 2 diabetes in the Finnish Diabetes Prevention Study and are associated with impaired glucose regulation and impaired insulin secretion.
}}

{{PMID Auto
|PMID=17470138
|Title=Association of TCF7L2 polymorphisms with type 2 diabetes in Mexico City.
}}

{{PMID Auto
|PMID=17476472
|Title=TCF7L2 is reproducibly associated with type 2 diabetes in various ethnic groups: a global meta-analysis.
}}

{{PMID Auto
|PMID=17503332
|Title=Type 2 diabetes TCF7L2 risk genotypes alter birth weight: a study of 24,053 individuals.
|OA=1
}}

{{PMID Auto
|PMID=17519421
|Title=Variation in TCF7L2 influences therapeutic response to sulfonylureas: a GoDARTs study.
}}

{{PMID Auto
|PMID=17579206
|Title=Association study of the genetic polymorphisms of the transcription factor 7-like 2 (TCF7L2) gene and type 2 diabetes in the Chinese population.
}}

{{PMID Auto
|PMID=17593304
|Title=TCF7L2 rs7903146 variant does not associate with smallness for gestational age in the French population.
|OA=1
}}

{{PMID Auto
|PMID=17601994
|Title=Variants of the transcription factor 7-like 2 (TCF7L2) gene are associated with type 2 diabetes in an African-American population enriched for nephropathy.
}}

{{PMID Auto
|PMID=17609304
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{{PMID Auto
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|Title=Variants of the TCF7L2 gene are associated with beta cell dysfunction and confer an increased risk of type 2 diabetes mellitus in the ULSAM cohort of Swedish elderly men.
}}

{{PMID Auto
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|OA=1
}}

{{PMID Auto
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|OA=1
}}

{{PMID Auto
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|Title=The rs12255372(G/T) and rs7903146(C/T) polymorphisms of the TCF7L2 gene are associated with type 2 diabetes mellitus in Asian Indians.
}}

{{PMID Auto
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|Title=The transcription factor 7-like 2 (TCF7L2) gene is associated with Type 2 diabetes in UK community-based cases, but the risk allele frequency is reduced compared with UK cases selected for genetic studies.
}}

{{PMID Auto
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|Title=Heterogeneity in meta-analyses of genome-wide association investigations.
|OA=1
}}

{{PMID Auto
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|Title=Disparate genetic influences on polycystic ovary syndrome (PCOS) and type 2 diabetes revealed by a lack of association between common variants within the TCF7L2 gene and PCOS.
}}

{{PMID Auto
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|Title=Genome-wide association with diabetes-related traits in the Framingham Heart Study.
|OA=1
}}

{{PMID Auto
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|Title=A variant of the transcription factor 7-like 2 (TCF7L2) gene and the risk of posttransplantation diabetes mellitus in renal allograft recipients.
}}

{{PMID Auto
|PMID=17972059
|Title=TCF7L2 is associated with high serum triacylglycerol and differentially expressed in adipose tissue in families with familial combined hyperlipidaemia.
}}

{{PMID Auto
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|Title=Association of TCF7L2 polymorphisms with susceptibility to type 2 diabetes in 4,087 Japanese subjects.
}}

{{PMID Auto
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|OA=1
}}

{{PMID Auto
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|Title=Prevalence of common disease-associated variants in Asian Indians.
|OA=1
}}

{{PMID Auto
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|OA=1
}}

{{PMID Auto
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}}

{{PMID Auto
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|Title=Common variants of the TCF7L2 gene are associated with increased risk of type 2 diabetes mellitus in a UK-resident South Asian population.
|OA=1
}}

{{PMID Auto
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|Title=Genetic similarities between latent autoimmune diabetes in adults, type 1 diabetes, and type 2 diabetes.
}}

{{PMID Auto
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|OA=1
}}

{{PMID Auto
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|Title=Association analysis of the FTO gene with obesity in children of Caucasian and African ancestry reveals a common tagging SNP.
|OA=1
}}

{{PMID Auto
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|Title=TCF7L2 polymorphisms are associated with type 2 diabetes in Khatri Sikhs from North India: genetic variation affects lipid levels.
}}

{{PMID Auto
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|OA=1
}}

{{PMID Auto
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|OA=1
}}

{{PMID Auto
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|OA=1
}}

{{PMID Auto
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|OA=1
}}

{{PMID Auto
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|OA=1
}}

{{PMID Auto
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|OA=1
}}

{{PMID Auto
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}}

{{PMID Auto
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{{PMID Auto
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}}

{{PMID Auto
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|OA=1
}}

{{PMID Auto
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}}

{{PMID Auto
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|OA=1
}}

{{PMID Auto
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|OA=1
}}

{{PMID Auto
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|OA=1
}}

{{PMID Auto
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|Title=Impact of TCF7L2 rs7903146 on insulin secretion and action in young and elderly Danish twins.
}}

{{PMID Auto
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|OA=1
}}

{{PMID Auto
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}}

{{PMID Auto
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{{PMID Auto
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}}

{{PMID Auto
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{{PMID Auto
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}}

{{PMID Auto
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|OA=1
}}

{{PMID Auto
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|OA=1
}}

{{PMID Auto
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|Title=Association of variants of the TCF7L2 gene with increases in the risk of type 2 diabetes and the proinsulin:insulin ratio in the Spanish population.
}}

{{PMID Auto
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{{PMID Auto
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}}

{{PMID Auto
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}}

{{PMID Auto
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{{PMID Auto
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|OA=1
}}

{{PMID Auto
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{{PMID Auto
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{{PMID Auto
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}}

{{PMID Auto
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|Title=Association analysis of variation in/near FTO, CDKAL1, SLC30A8, HHEX, EXT2, IGF2BP2, LOC387761, and CDKN2B with type 2 diabetes and related quantitative traits in Pima Indians.
|OA=1
}}

{{PMID Auto
|PMID=19012045
|Title=Common coding variant in the TCF7L2 gene and study of the association with type 2 diabetes in Japanese subjects.
}}

{{PMID Auto
|PMID=19020323
|Title=Genotype score in addition to common risk factors for prediction of type 2 diabetes.
|OA=1
}}

{{PMID Auto
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|Title=Replication study of candidate genes associated with type 2 diabetes based on genome-wide screening.
|OA=1
}}

{{PMID Auto
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|OA=1
}}

{{PMID Auto
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}}

{{PMID Auto
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|OA=1
}}

{{PMID Auto
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{{PMID Auto
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|OA=1
}}

{{PMID Auto
|PMID=19149908
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}}

{{PMID Auto
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|Title=An open access database of genome-wide association results.
|OA=1
}}

{{PMID Auto
|PMID=19169495
|Title=Allele-specific PCR assay to genotype SNP rs7903146 in TCF7L2 gene for rapid screening of diabetes susceptibility.
}}

{{PMID Auto
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|Title=The risk allele load accelerates the age-dependent decline in beta cell function.
}}

{{PMID Auto
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}}

{{PMID Auto
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}}

{{PMID Auto
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|Title=The T allele of rs7903146 TCF7L2 is associated with impaired insulinotropic action of incretin hormones, reduced 24 h profiles of plasma insulin and glucagon, and increased hepatic glucose production in young healthy men.
}}

{{PMID Auto
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|OA=1
}}

{{PMID Auto
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|OA=1
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{{PMID Auto
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}}

{{PMID Auto
|PMID=19368707
|Title=Contribution of type 2 diabetes associated loci in the Arabic population from Tunisia: a case-control study.
|OA=1
}}

{{PMID Auto
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{{PMID Auto
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|OA=1
}}

{{PMID Auto
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{{PMID Auto
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{{PMID Auto
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}}

{{PMID Auto
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|OA=1
}}

{{PMID Auto
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|OA=1
}}

{{PMID Auto
|PMID=19602480
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|OA=1
}}

{{PMID Auto
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|OA=1
}}

{{PMID Auto
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|OA=1
}}

{{PMID Auto
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|OA=1
}}

{{PMID Auto
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|Title=Association of common type 2 diabetes risk gene variants and posttransplantation diabetes mellitus in renal allograft recipients in Korea.
}}

{{PMID Auto
|PMID=19750184
|Title=Genome-wide association studies for atherosclerotic vascular disease and its risk factors.
|OA=1
}}

{{PMID Auto
|PMID=19789636
|Title=Alternative splicing of TCF7L2 gene in omental and subcutaneous adipose tissue and risk of type 2 diabetes.
|OA=1
}}

{{PMID Auto
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|Title=TCF7L2 polymorphisms and inflammatory markers before and after treatment with fenofibrate.
|OA=1
}}

{{PMID Auto
|PMID=19862325
|Title=PPARG, KCNJ11, CDKAL1, CDKN2A-CDKN2B, IDE-KIF11-HHEX, IGF2BP2 and SLC30A8 are associated with type 2 diabetes in a Chinese population.
|OA=1
}}

{{PMID Auto
|PMID=19885641
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{{PMID Auto
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|OA=1
}}

{{PMID Auto
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}}

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|OA=1
}}

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|OA=1
}}

{{PMID Auto
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|OA=1
}}

{{PMID Auto
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{{PMID Auto
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|OA=1
}}

{{PMID Auto
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|OA=1
}}

{{PMID Auto
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|OA=1
}}

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|OA=1
}}

{{PMID Auto
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|Title=The T-allele of TCF7L2 rs7903146 associates with a reduced compensation of insulin secretion for insulin resistance induced by 9 days of bed rest.
|OA=1
}}

{{PMID Auto
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|OA=1
}}

{{PMID Auto
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|OA=1
}}

{{PMID Auto
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|OA=1
}}

{{PMID Auto
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|OA=1
}}

{{PMID Auto
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|OA=1
}}

{{PMID Auto
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|OA=1
}}

{{PMID Auto
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|Title=Transcription factor 7-like 2 (TCF7L2) polymorphism and hyperglycemia in an adult Italian population-based cohort.
|OA=1
}}

{{PMID Auto
|PMID=20361036
|Title=Gene-gene interactions lead to higher risk for development of type 2 diabetes in an Ashkenazi Jewish population.
|OA=1
}}

{{PMID Auto
|PMID=20424228
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|OA=1
}}

{{PMID Auto
|PMID=20470430
|Title=Common polymorphisms of calpain-10 and the risk of Type 2 Diabetes in a Tunisian Arab population: a case-control study.
|OA=1
}}

{{PMID Auto
|PMID=20478041
|Title=The transcription factor 7-like 2 (TCF7L2) polymorphism may be associated with focal arteriolar narrowing in Caucasians with hypertension or without diabetes: the ARIC Study.
|OA=1
}}

{{PMID Auto
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|OA=1
}}

{{PMID Auto
|PMID=20540670
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}}

{{PMID Auto
|PMID=20550665
|Title=Association study of genetic variants in eight genes/loci with type 2 diabetes in a Han Chinese population.
|OA=1
}}

{{PMID Auto
|PMID=20648057
|Title=Potential role of TCF7L2 gene variants on cardiac sympathetic/parasympathetic activity.
|OA=1
}}

{{PMID Auto
|PMID=20712903
|Title=Obesity and diabetes genes are associated with being born small for gestational age: results from the Auckland Birthweight Collaborative study.
|OA=1
}}

{{PMID Auto
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|Title=Carriers of the TCF7L2 rs7903146 TT genotype have elevated levels of plasma glucose, serum proinsulin and plasma gastric inhibitory polypeptide (GIP) during a meal test.
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{{PMID Auto
|PMID=21115178
|Title=Pleiotropic effects of TCF7L2 gene variants and its modulation in the metabolic syndrome: from the LIPGENE study.
}}

{{PMID Auto
|PMID=21159844
|Title=Variants and haplotypes of TCF7L2 are associated with beta-cell function in patients with newly diagnosed type 2 diabetes: the Verona Newly Diagnosed Type 2 Diabetes Study (VNDS) 1.
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{{PMID Auto
|PMID=21278902
|Title=Genetic risk profiling for prediction of type 2 diabetes.
|OA=1
}}

{{PMID Auto
|PMID=21283728
|Title=Genetic variants of diabetes risk and incident cardiovascular events in chronic coronary artery disease.
|OA=1
}}

{{PMID Auto
|PMID=21347282
|Title=Genome-wide association study of coronary heart disease and its risk factors in 8,090 African Americans: the NHLBI CARe Project.
|OA=1
}}

{{PMID Auto
|PMID=21349175
|Title=TCF7L2 and therapeutic response to sulfonylureas in patients with type 2 diabetes.
|OA=1
}}

{{PMID Auto
|PMID=21384500
|Title=Association of TCF7L2 SNPs with age at onset of type 2 diabetes and proinsulin/insulin ratio but not with glucagon-like peptide 1.
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{{PMID Auto
|PMID=21423583
|Title=Single nucleotide polymorphisms of TCF7L2 are linked to diabetic coronary atherosclerosis.
|OA=1
}}

{{PMID Auto
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{{PMID Auto
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|OA=1
}}

{{PMID Auto
|PMID=21672010
|Title=Gestational diabetes mellitus is associated with TCF7L2 gene polymorphisms independent of HLA-DQB1*0602 genotypes and islet cell autoantibodies.
|OA=1
}}

{{PMID Auto
|PMID=21834909
|Title=A replication study of the IRS1, CAPN10, TCF7L2, and PPARG gene polymorphisms associated with type 2 diabetes in two different populations of Mexico.
}}

{{PMID Auto
|PMID=21898192
|Title=Worldwide distribution of type II diabetes-associated TCF7L2 SNPs: evidence for stratification in Europe.
}}

{{PMID Auto
|PMID=21965303
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}}

{{PMID Auto
|PMID=22377714
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}}

{{PMID Auto
|PMID=22461567
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|OA=1
}}

{{PMID Auto
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{{PMID Auto
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|OA=1
}}

{{PMID Auto GWAS
|PMID=22693455
|Trait=None
|Title=Stratifying type 2 diabetes cases by BMI identifies genetic risk variants in LAMA1 and enrichment for risk variants in lean compared to obese cases.
|RiskAllele=T
|Pval=4E-21
|OR=1.2600
|ORtxt=None
|OA=1
}}

{{PMID Auto GWAS
|PMID=22581228
|Trait=None
|Title=A genome-wide approach accounting for body mass index identifies genetic variants influencing fasting glycemic traits and insulin resistance.
|RiskAllele=
|Pval=2E-14
|OR=None
|ORtxt=None
|OA=1
}}

{{PMID Auto
|PMID=23014255
|Title=Relationship of transcription factor 7 like 2 gene rs7903146 variation with type 2 diabetes and obesity related parameters
}}

{{PMID Auto
|PMID=23041303
|Title=Association between donor and recipient TCF7L2 gene polymorphisms and the risk of new-onset diabetes mellitus after liver transplantation in a Han Chinese population
}}

{{GET Evidence
|impact=pathogenic
|qualified_impact=Insufficiently evaluated pathogenic
|inheritance=unknown
|quality_scores=Array
|dbsnp_id=rs7903146
|overall_frequency_n=31
|overall_frequency_d=128
|overall_frequency=0.242188
|n_genomes=23
|n_genomes_annotated=0
|n_haplomes=28
|n_articles=6
|n_articles_annotated=6
|qualityscore_case_control=2
|qualitycomment_case_control=Y
|in_gwas=Y
|in_pharmgkb=Y
|autoscore=2
|webscore=N
|summary_short=associated with colorectal cancer for the T allele. 
}}

{{PMID Auto
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|Title=Transferability and Fine Mapping of Type 2 Diabetes Loci in African Americans: The Candidate Gene Association Resource Plus Study
|OA=1
}}

{{PMID Auto
|PMID=23249316
|Title=Genetic susceptibility to type 2 diabetes: a global meta-analysis studying the genetic differences in tunisian populations
}}

{{PMID Auto
|PMID=23029294
|Title=Meta-analysis of the relationship between common type 2 diabetes risk gene variants with gestational diabetes mellitus
|OA=1
}}

{{PMID Auto
|PMID=23527042
|Title=Replication of type 2 diabetes candidate genes variations in three geographically unrelated Indian population groups
|OA=1
}}

{{PMID Auto
|PMID=23536853
|Title=Association of rs7903146 (IVS3C/T) and rs290487 (IVS3C/T) Polymorphisms in TCF7L2 with Type 2 Diabetes in 9,619 Han Chinese Population
|OA=1
}}

{{PMID Auto GWAS
  |PMID=23300278
  |Trait=Type 2 diabetes
  |Title=Genome-Wide Association Study Identifies a Novel Locus Contributing to Type 2 Diabetes Susceptibility in Sikhs of Punjabi Origin From India.
  |RiskAllele=T
  |Pval=2E-38
  |OR=1.15
  |ORtxt=[1.12 - 1.17]
  |OA=1
}}

{{PMID Auto
|PMID=23311683
|Title=Meta-analysis of associations between TCF7L2 polymorphisms and risk of type 2 diabetes mellitus in the Chinese population
|OA=1
}}

{{PMID Auto GWAS
  |PMID=23209189
  |Trait=Type 2 diabetes
  |Title=Genome-wide association study for type 2 diabetes in indians identifies a new susceptibility locus at 2q21.
  |RiskAllele=T
  |Pval=1E-35
  |OR=1.51
  |ORtxt=[1.42-1.62]
  |OA=1
}}

{{PMID Auto
|PMID=23577093
|Title=Association of TCF7L2 Gene Polymorphisms with T2DM in the Population of Hyderabad, India
|OA=1
}}

{{PMID Auto
|PMID=23690305
|Title=Genetic variants and the risk of gestational diabetes mellitus: a systematic review
}}

{{PMID Auto
|PMID=22749234
|Title=Contribution of common variants of ENPP1, IGF2BP2, KCNJ11, MLXIPL, PPARγ, SLC30A8 and TCF7L2 to the risk of type 2 diabetes in Lebanese and Tunisian Arabs
}}

{{PMID Auto
|PMID=23188737
|Title=TCF7L2 gene polymorphisms and type 2 diabetes risk: a comprehensive and updated meta-analysis involving 121,174 subjects
}}

{{PMID Auto
|PMID=23926018
|Title=[Study of the association between SNP rs7903146(C/T) in TCF7L2 and metabolic syndrome in Chinese Korean and Han populations from Yanbian]
}}

{{PMID Auto
|PMID=23942764
|Title=Parental history of type 2 diabetes, TCF7L2 variant and lower insulin secretion are associated with incident hypertension. Data from the DESIR and RISC cohorts
}}

{{PMID Auto
|PMID=23942586
|Title=Mediterranean Diet Reduces the Adverse Effect of the TCF7L2-rs7903146 Polymorphism on Cardiovascular Risk Factors and Stroke Incidence: A randomized controlled trial in a high-cardiovascular-risk population
}}

{{PMID Auto
|PMID=24157263
|Title=Polymorphisms of Transcription Factor-7-Like 2 (TCF7L2) gene in Tunisian women with polycystic ovaries syndrome (PCOS)
}}

{{PMID Auto
|PMID=24371822
|Title=IRS1, TCF7L2, ADRB1, PPARG, and HHEX Polymorphisms Associated with Atherogenic Risk in Mexican Population
|OA=1
}}

{{PMID Auto
|PMID=24435973
|Title=Association between type 2 diabetes mellitus-related SNP variants and obesity traits in a Saudi population
}}

{{PMID Auto
|PMID=24498581
|Title=Role of the single nucleotide polymorphism rs7903146 of TCF7L2 in inducing nonsense-mediated decay
|OA=1
}}

{{PMID Auto
|PMID=24529562
|Title=Transcription factor 7-like 2 (TCF7L2) gene polymorphism rs7903146 is associated with stroke in type 2 diabetes patients with long disease duration
}}

{{PMID Auto
|PMID=24574000
|Title=Transcription factor 7-like 2 (TCF7L2) gene polymorphism and clinical phenotype in end-stage renal disease patients
}}

{{PMID Auto
|PMID=22480428
|Title=T2D risk haplotypes of the TCF7L2 gene in the Czech population sample: the association with free fatty acids composition.
}}

{{PMID Auto
|PMID=22782288
|Title=Role of TCF7L2 risk variant and dietary fibre intake on incident type 2 diabetes.
|OA=1
}}

{{PMID Auto
|PMID=22843023
|Title=TCF7L2 gene polymorphisms and type 2 diabetes: association with diabetic retinopathy and cardiovascular autonomic neuropathy.
}}

{{PMID Auto
|PMID=22862926
|Title=Incretin and pancreatic hormone secretion in Caucasian non-diabetic carriers of the TCF7L2 rs7903146 risk T allele.
}}

{{PMID Auto
|PMID=22872755
|Title=Using gene-network landscape to dissect genotype effects of TCF7L2 genetic variant on diabetes and cardiovascular risk.
}}

{{PMID Auto
|PMID=22911383
|Title=TCF7L2 rs7903146 impairs islet function and morphology in non-diabetic individuals.
}}

{{PMID Auto
|PMID=22923468
|Title=Contribution of common genetic variation to the risk of type 2 diabetes in the Mexican Mestizo population.
|OA=1
}}

{{PMID Auto
|PMID=22936689
|Title=Pancreatic beta-cell function and type 2 diabetes risk: quantify the causal effect using a Mendelian randomization approach based on meta-analyses.
|OA=1
}}

{{PMID Auto
|PMID=22996130
|Title=From mice to humans.
|OA=1
}}

{{PMID Auto
|PMID=23010200
|Title=Association of TCF7L2 gene polymorphisms with type 2 diabetes mellitus in Han Chinese population: a meta-analysis.
}}

{{PMID Auto
|PMID=23011354
|Title=In vitro scan for enhancers at the TCF7L2 locus.
|OA=1
}}

{{PMID Auto
|PMID=23034957
|Title=TCF7L2 genetic variants modulate the effect of dietary fat intake on changes in body composition during a weight-loss intervention.
|OA=1
}}

{{PMID Auto
|PMID=23085767
|Title=Associations between TCF7L2 polymorphisms and risk of breast cancer among Hispanic and non-Hispanic white women: the Breast Cancer Health Disparities Study.
|OA=1
}}

{{PMID Auto
|PMID=23107111
|Title=Transcription factor-7-like 2 gene variants are strongly associated with type 2 diabetes in Lebanese subjects.
}}

{{PMID Auto
|PMID=23142382
|Title=Transcription factor-7-like 2 gene variants are strongly associated with type 2 diabetes in Tunisian Arab subjects.
}}

{{PMID Auto
|PMID=23334806
|Title=Systematic identification of interaction effects between genome- and environment-wide associations in type 2 diabetes mellitus.
|OA=1
}}

{{PMID Auto
|PMID=23434931
|Title=TCF7L2 variation and proliferative diabetic retinopathy.
}}

{{PMID Auto
|PMID=23458876
|Title=ACE I/D and MTHFR C677T polymorphisms are significantly associated with type 2 diabetes in Arab ethnicity: a meta-analysis.
}}

{{PMID Auto
|PMID=23462794
|Title=Identification of CpG-SNPs associated with type 2 diabetes and differential DNA methylation in human pancreatic islets.
|OA=1
}}

{{PMID Auto
|PMID=23855352
|Title=Association of the rs7903146 polymorphism in transcription factor 7-like 2 (TCF7L2) gene with gestational diabetes mellitus: a meta-analysis.
}}

{{PMID Auto
|PMID=24864085
|Title=Is TCF7L2 variant associated with non-diabetic chronic kidney disease progression? Results of a family-based study
}}

{{PMID Auto
|PMID=24906949
|Title=Influence of TCF7L2 gene variants on the therapeutic response to the dipeptidylpeptidase-4 inhibitor linagliptin
}}

{{PMID Auto
|PMID=24925104
|Title=Clinical and non-targeted metabolomic profiling of homozygous carriers of Transcription Factor 7-like 2 variant rs7903146
}}

{{PMID Auto
|PMID=25058603
|Title=Differential transcriptional and post-translational Transcription factor 7-like regulation among nondiabetic individuals and type 2 diabetic patients
}}

{{PMID Auto GWAS
  |PMID=24390345
  |Trait=Type 2 diabetes
  |Title=Sequence variants in SLC16A11 are a common risk factor for type 2 diabetes in Mexico.
  |RiskAllele=T
  |Pval=1E-14
  |OR=1.37
  |ORtxt=[1.27-1.48]
  }}

{{PMID Auto
|PMID=25185411
|Title=Association of rs7903146, rs12255372, and rs290487 polymorphisms in TCF7L2 gene with type 2 diabetes in an Iranian Kurdish ethnic group
}}

{{PMID Auto
|PMID=25224167
|Title=Weight loss independent association of TCF7 L2 gene polymorphism with fasting blood glucose after Roux-en-Y gastric bypass in type 2 diabetic patients
}}
{{on chip | 23andMe v1}}
{{on chip | 23andMe v2}}
{{on chip | 23andMe v3}}
{{on chip | 23andMe v4}}
{{on chip | HumanOmni1Quad}}
{{on chip | Illumina Human 1M}}