{{Rsnum
|rsid=7910977
|Gene=IDE
|Chromosome=10
|position=94209876
|Orientation=plus
|GMAF=0.18
|Assembly=GRCh37.p2
|GenomeBuild=37.2
|dbSNPBuild=134
|geno1=(C;C)
|geno2=(C;T)
|geno3=(T;T)
}}
{{ population diversity
| geno1=(C;C)
| geno2=(C;T)
| geno3=(T;T)
| CEU | 75.2 | 22.1 | 2.7
| HCB | 67.2 | 29.9 | 2.9
| JPT | 55.8 | 33.6 | 10.6
| YRI | 50.7 | 41.1 | 8.2
| ASW | 40.4 | 52.6 | 7.0
| CHB | 67.2 | 29.9 | 2.9
| CHD | 69.4 | 29.6 | 0.9
| GIH | 66.3 | 30.7 | 3.0
| LWK | 72.5 | 23.9 | 3.7
| MEX | 58.6 | 32.8 | 8.6
| MKK | 75.5 | 21.9 | 2.6
| TSI | 81.4 | 17.6 | 1.0
| HapMapRevision=28
}}

[[rs7910977]] is a SNP of the [[IDE]] gene, which encodes the insulin-degrading enzyme.

Late onset [[Alzheimer's disease]] is a neurodegenerative condition in which the brain develops large numbers of extracellular senile plaques composed primarily of aggregated amyloid-B proteins as well as intraneuronal neurofibrillary tangles composed mainly of aggregated tau protein.{{PMID|15450169}} One notable function of insulin-degrading enzyme is its ability to degrade amyloid-B and therefore to influence the amount of amyloid-B found in the brain.{{PMID|12634421|OA=1
}}

The [[rs7910977]](T) allele is associated with reduced risk of Alzheimer's disease in one study of ~3,000 patients, and in this study, the conclusion was that it was most likely due to near perfect linkage with [[rs6583817]], a nearby functional variant. [[rs6583817]](T) allele carriers had an odds ratio for late onset Alzheimer's disease of around 0.80 (p<0.03).{{PMID|20098734|OA=1
}}

{{PMID Auto
|PMID=20142614
|Title=Gene expression levels as endophenotypes in genome-wide association studies of Alzheimer disease
|OA=1
}}

{{omim
|id=605526
|rsnum=7910977
}}

{{PMID Auto
|PMID=24477584
|Title=Genetic association of IDE, POU2F1, PON1, IL1α and IL1β with type 2 diabetes in Pakistani population
}}
{{on chip | 23andMe v1}}
{{on chip | 23andMe v2}}
{{on chip | 23andMe v3}}
{{on chip | 23andMe v4}}
{{on chip | Illumina Human 1M}}