{{Rsnum
|rsid=7923837
|Chromosome=10
|position=94481917
|Orientation=plus
|GMAF=0.427
|Assembly=GRCh37
|GenomeBuild=37.1
|dbSNPBuild=131
|geno1=(A;A)
|geno2=(A;G)
|geno3=(G;G)
}}
{{ population diversity
| geno1=(A;A)
| geno2=(A;G)
| geno3=(G;G)
| CEU | 15.9 | 41.6 | 42.5
| HCB | 60.3 | 33.1 | 6.6
| JPT | 63.7 | 31.9 | 4.4
| YRI | 0.0 | 0.0 | 100.0
| ASW | 0.0 | 21.1 | 78.9
| CHB | 60.3 | 33.1 | 6.6
| CHD | 63.0 | 32.4 | 4.6
| GIH | 33.7 | 56.4 | 9.9
| LWK | 0.0 | 15.5 | 84.5
| MEX | 12.1 | 50.0 | 37.9
| MKK | 2.6 | 21.2 | 76.3
| TSI | 15.7 | 40.2 | 44.1
| HapMapRevision=28
}}[[rs7923837]] is a SNP of the [[HHEX]] homeobox gene. In several studies, it has been associated with risk for [[type-2 diabetes]] (T2D).

In a study of 500 unrelated Caucasian T2D patients, the [[rs7923837]](G) allele was overrepresented; the odds ratio was 1.57 (CI: 1.08-2.27, p=0.017). In this population, the population attributable risk for this allele was estimated to be 33%.{{PMID|18231124}} 

In a study of ~400 Japanese T2D patients, [[rs7923837]](G) was also associated with [[type-2 diabetes]] (odds ratio 1.66, CI: 1.28-2.15, p=0.00014). Heterozygous and homozygous carriers of the risk allele had odds ratios of 1.57 (95% CI 1.15-2.16, p=0.0050) and 3.16 (95% CI 1.40-7.16, p=0.0038) relative to non-carriers.{{PMID|17971426}}

{{PMID|18477659}} [[rs7923837]] replicated as significant for [[type-2 diabetes]] risk in 1,900 Japanese patients, with odds ratio of 1.27 (CI: 1.13-1.43, p = 1.0 x 10e-4)

{{PMID|19033397|OA=1
}} This SNP was confirmed to be associated with [[type-2 diabetes]] in a study of 500+ Japanese patients plus pooled meta-analysis with 6 previous association studies (also of Japanese).

{{PMID|19117022}} [[rs7923837]] and [[rs1111875]] were significantly associated with decreased insulin secretion and lower insulinogenic index in a study of 420 Germans in the MESYBEOP cohort.

{{omim
|desc=DIABETES MELLITUS, NONINSULIN-DEPENDENT; NIDDM
|id=125853
|rsnum=7923837
}}
{{PMID Auto
|PMID=20043145
|Title=Improvements in glucose homeostasis in response to regular exercise are influenced by the PPARG Pro12Ala variant: results from the HERITAGE Family Study
|OA=1
}}

{{PMID Auto
|PMID=20802253
|Title=Glycemia determines the effect of type 2 diabetes risk genes on insulin secretion
|OA=1
}}
{{PMID Auto
|PMID=21059810
|Title=Meta-analysis of the effect of HHEX gene polymorphism on the risk of type 2 diabetes
}}

{{PMID Auto GWAS
|PMID=21833088
|Trait=None
|Title=Genetic risk and a primary role for cell-mediated immune mechanisms in multiple sclerosis.
|RiskAllele=G
|Pval=5E-9
|OR=1.1000
|ORtxt=[1.08-1.11]
|OA=1
}}

{{PMID Auto
|PMID=22506066
|Title=Genetic Variants of IDE-KIF11-HHEX at 10q23.33 Associated with Type 2 Diabetes Risk: A Fine-Mapping Study in Chinese Population
|OA=1
}}

{{PMID Auto
|PMID=17786204
|Title=Polymorphisms within novel risk loci for type 2 diabetes determine beta-cell function.
|OA=1
}}

{{PMID Auto
|PMID=17928989
|Title=Variations in the HHEX gene are associated with increased risk of type 2 diabetes in the Japanese population.
}}

{{PMID Auto
|PMID=18039816
|Title=A candidate type 2 diabetes polymorphism near the HHEX locus affects acute glucose-stimulated insulin release in European populations: results from the EUGENE2 study.
}}

{{PMID Auto
|PMID=18162508
|Title=Association of CDKAL1, IGF2BP2, CDKN2A/B, HHEX, SLC30A8, and KCNJ11 with susceptibility to type 2 diabetes in a Japanese population.
}}

{{PMID Auto
|PMID=18264689
|Title=Polymorphisms in the TCF7L2, CDKAL1 and SLC30A8 genes are associated with impaired proinsulin conversion.
}}

{{PMID Auto
|PMID=18426861
|Title=Association analysis of type 2 diabetes Loci in type 1 diabetes.
|OA=1
}}

{{PMID Auto
|PMID=18443202
|Title=Association analysis in african americans of European-derived type 2 diabetes single nucleotide polymorphisms from whole-genome association studies.
|OA=1
}}

{{PMID Auto
|PMID=18461161
|Title=Post genome-wide association studies of novel genes associated with type 2 diabetes show gene-gene interaction and high predictive value.
|OA=1
}}

{{PMID Auto
|PMID=18469204
|Title=Implication of genetic variants near TCF7L2, SLC30A8, HHEX, CDKAL1, CDKN2A/B, IGF2BP2, and FTO in type 2 diabetes and obesity in 6,719 Asians.
|OA=1
}}

{{PMID Auto
|PMID=18544707
|Title=Extension of type 2 diabetes genome-wide association scan results in the diabetes prevention program.
|OA=1
}}

{{PMID Auto
|PMID=18556337
|Title=Impact of diabetes susceptibility loci on progression from pre-diabetes to diabetes in at-risk individuals of the diabetes prevention trial-type 1 (DPT-1).
|OA=1
}}

{{PMID Auto
|PMID=18633108
|Title=Common variants in CDKAL1, CDKN2A/B, IGF2BP2, SLC30A8, and HHEX/IDE genes are associated with type 2 diabetes and impaired fasting glucose in a Chinese Han population.
|OA=1
}}

{{PMID Auto
|PMID=18654633
|Title=Simultaneous analysis of all SNPs in genome-wide and re-sequencing association studies.
|OA=1
}}

{{PMID Auto
|PMID=18689899
|Title=Exchangeable models of complex inherited diseases.
|OA=1
}}

{{PMID Auto
|PMID=19002430
|Title=Type 2 diabetes-associated genetic variants discovered in the recent genome-wide association studies are related to gestational diabetes mellitus in the Korean population.
}}

{{PMID Auto
|PMID=19172244
|Title=The risk allele load accelerates the age-dependent decline in beta cell function.
}}

{{PMID Auto
|PMID=19368707
|Title=Contribution of type 2 diabetes associated loci in the Arabic population from Tunisia: a case-control study.
|OA=1
}}

{{PMID Auto
|PMID=19741467
|Title=Association of common type 2 diabetes risk gene variants and posttransplantation diabetes mellitus in renal allograft recipients in Korea.
}}

{{PMID Auto
|PMID=19933996
|Title=Examination of all type 2 diabetes GWAS loci reveals HHEX-IDE as a locus influencing pediatric BMI.
|OA=1
}}

{{PMID Auto
|PMID=20080751
|Title=Long-range gene regulation links genomic type 2 diabetes and obesity risk regions to HHEX, SOX4, and IRX3.
|OA=1
}}

{{PMID Auto
|PMID=20126254
|Title=Rare variants create synthetic genome-wide associations.
|OA=1
}}

{{PMID Auto
|PMID=20532014
|Title=The epidemiology of diabetes in Korea: from the economics to genetics.
|OA=1
}}

{{PMID Auto
|PMID=20550665
|Title=Association study of genetic variants in eight genes/loci with type 2 diabetes in a Han Chinese population.
|OA=1
}}

{{PMID Auto
|PMID=20580033
|Title=Replication of recently described type 2 diabetes gene variants in a South Indian population.
}}

{{PMID Auto
|PMID=21278902
|Title=Genetic risk profiling for prediction of type 2 diabetes.
|OA=1
}}

{{PMID Auto
|PMID=24468095
|Title=Genetic variants for type 2 diabetes and new-onset cancer in Chinese with type 2 diabetes
}}

{{PMID Auto
|PMID=22923468
|Title=Contribution of common genetic variation to the risk of type 2 diabetes in the Mexican Mestizo population.
|OA=1
}}

{{PMID Auto
|PMID=23458876
|Title=ACE I/D and MTHFR C677T polymorphisms are significantly associated with type 2 diabetes in Arab ethnicity: a meta-analysis.
}}

{{on chip | 23andMe v1}}
{{on chip | 23andMe v2}}
{{on chip | 23andMe v3}}
{{on chip | 23andMe v4}}
{{on chip | FTDNA2}}
{{on chip | HumanOmni1Quad}}
{{on chip | Illumina Human 1M}}