{{Rsnum
|rsid=7944584
|Gene=MADD
|Chromosome=11
|position=47314769
|Orientation=plus
|GMAF=0.1368
|Assembly=GRCh38
|GenomeBuild=38.1
|dbSNPBuild=141
|geno1=(A;A)
|geno2=(A;T)
|geno3=(T;T)
|Gene_s=MADD
}}{{ population diversity
| geno1=(A;A)
| geno2=(A;T)
| geno3=(T;T)
| CEU | 53.1 | 36.3 | 10.6
| HCB | 92.0 | 8.0 | 0.0
| JPT | 95.6 | 4.4 | 0.0
| YRI | 100.0 | 0.0 | 0.0
| ASW | 87.7 | 10.5 | 1.8
| CHB | 92.0 | 8.0 | 0.0
| CHD | 95.4 | 4.6 | 0.0
| GIH | 60.4 | 35.6 | 4.0
| LWK | 0.0 | 0.0 | 0.0
| MEX | 65.5 | 29.3 | 5.2
| MKK | 92.9 | 7.1 | 0.0
| TSI | 41.2 | 41.2 | 17.6
| HapMapRevision=28
}}{{PMID Auto GWAS
|PMID=20081858
|Trait=Fasting glucose-related traits
|Title=New genetic loci implicated in fasting glucose homeostasis and their impact on type 2 diabetes risk
|RiskAllele=A
|Pval=2E-18
|OR=None
|ORtxt=None
|OA=1
}}

{{PharmGKB
|RSID=rs7944584
|Name_s=
|Gene_s=MADD
|Feature=
|Evidence=PubMed ID:20081858
|Annotation=Phenotype : In a meta-analysis of 21 GWAS cohorts followed by analysis in additional individuals, this SNP was found to be associated with fasting glucose level. Study size: 118,741. Significance metric(s): p = 2.0 x 10(-18). Study population/ethnicity: Non-diabetic Individuals of European descent. Type of association: CO;GN.
|Drugs=
|Drug Classes=
|Diseases=Diabetes Mellitus, Type 2
|Curation Level=Curated
|PharmGKB Accession ID=PA165281939
}}

{{PMID Auto
|PMID=21887289
|Title=Glucose-Raising Genetic Variants in MADD and ADCY5 Impair Conversion of Proinsulin to Insulin
|OA=1
}}

{{PMID Auto GWAS
|PMID=22581228
|Trait=None
|Title=A genome-wide approach accounting for body mass index identifies genetic variants influencing fasting glycemic traits and insulin resistance.
|RiskAllele=
|Pval=4E-12
|OR=None
|ORtxt=None
|OA=1
}}

{{GET Evidence
|impact=pharmacogenetic
|qualified_impact=Insufficiently evaluated pharmacogenetic
|inheritance=unknown
|quality_scores=Array
|dbsnp_id=rs7944584
|overall_frequency_n=22
|overall_frequency_d=128
|overall_frequency=0.171875
|n_genomes=13
|n_genomes_annotated=0
|n_haplomes=16
|n_articles=2
|n_articles_annotated=2
|in_pharmgkb=Y
|autoscore=1
|webscore=N
}}

{{PMID Auto
|PMID=24951664
|Title=Association of Levels of Fasting Glucose and Insulin With Rare Variants at the Chromosome 11p11.2-MADD Locus: Cohorts for Heart and Aging Research in Genomic Epidemiology (CHARGE) Consortium Targeted Sequencing Study
}}
{{on chip | 23andMe v3}}
{{on chip | 23andMe v4}}
{{on chip | Affy GenomeWide 6}}