{{Rsnum
|rsid=7961894
|Gene=WDR66
|Chromosome=12
|position=121927677
|Orientation=plus
|GMAF=0.04224
|Assembly=GRCh38
|GenomeBuild=38.1
|dbSNPBuild=141
|geno1=(C;C)
|geno2=(C;T)
|geno3=(T;T)
|Gene_s=WDR66
}}{{ population diversity
| geno1=(C;C)
| geno2=(C;T)
| geno3=(T;T)
| CEU | 79.5 | 19.6 | 0.9
| HCB | 100.0 | 0.0 | 0.0
| JPT | 100.0 | 0.0 | 0.0
| YRI | 100.0 | 0.0 | 0.0
| ASW | 98.2 | 1.8 | 0.0
| CHB | 100.0 | 0.0 | 0.0
| CHD | 0.0 | 0.0 | 0.0
| GIH | 97.0 | 3.0 | 0.0
| LWK | 0.0 | 0.0 | 0.0
| MEX | 86.2 | 13.8 | 0.0
| MKK | 0.0 | 0.0 | 0.0
| TSI | 90.2 | 8.8 | 1.0
| HapMapRevision=28
}}{{PMID|19110211|OA=1
}} [[rs7961894]], [[rs12485738]] and [[rs2138852]] together accounted for 4%-5% of the variance in mean platelet volume, which is increased in myocardial and cerebral infarction and is an independent and strong predictor for postevent morbidity and mortality

{{omim
|desc=MEAN PLATELET VOLUME QUANTITATIVE TRAIT LOCUS 1; MPVQTL1
|id=612573
|rsnum=7961894
}}
{{PMID Auto GWAS
|PMID=19820697
|Trait=MPV
|Title=A genome-wide meta-analysis identifies 22 loci associated with eight hematological parameters in the HaemGen consortium
|RiskAllele=T
|Pval=3E-44
|OR=0.03
|ORtxt=[0.027-0.035] fl increase
|OA=1
}}

{{PharmGKB
|RSID=rs7961894
|Name_s=
|Gene_s=WDR66
|Feature=
|Evidence=PubMed ID:19110211
|Annotation=In replicated GWAS (three replication groups) of German and UK populations, this SNP was found to be strongly associated with Mean Platelet Volume, the A allele being over-represented in the high MPV group. Combined N = 10,034; p= 7.24 x 10 ( -48).
|Drugs=
|Drug Classes=
|Diseases=Cerebral Infarction; Infarction; Myocardial Infarction
|Curation Level=Curated
|PharmGKB Accession ID=PA164920503
}}

{{PharmGKB
|RSID=rs7961894
|Name_s=
|Gene_s=WDR66
|Feature=
|Evidence=PubMed ID:19110211; Web Resource:http://www.genome.gov/gwastudies/
|Annotation=GWAS results: A genome-wide association study identifies three loci associated with mean platelet volume. (Initial Sample Size: 1,606 individuals; Replication Sample Size: 8,617 individuals); (Region: 12q24.31; Reported Gene(s): WDR66; Risk Allele: rs7961894-A); (p-value= 7E-48).This variant is associated with Mean platelet volume.
|Drugs=
|Drug Classes=
|Diseases=
|Curation Level=Non-Curated
|PharmGKB Accession ID=PA164740098
}}

{{PMID Auto GWAS
|PMID=22139419
|Trait=None
|Title=New gene functions in megakaryopoiesis and platelet formation.
|RiskAllele=C
|Pval=1E-10
|OR=3.9230
|ORtxt=None
|OA=1
}}

{{GET Evidence
|impact=pathogenic
|qualified_impact=Insufficiently evaluated pathogenic
|inheritance=unknown
|quality_scores=Array
|dbsnp_id=rs7961894
|overall_frequency_n=7
|overall_frequency_d=128
|overall_frequency=0.0546875
|n_genomes=4
|n_genomes_annotated=0
|n_haplomes=4
|n_articles=1
|n_articles_annotated=0
|in_gwas=Y
|in_pharmgkb=Y
|autoscore=2
|webscore=N
}}

{{on chip | 23andMe v1}}
{{on chip | 23andMe v2}}
{{on chip | 23andMe v3}}
{{on chip | 23andMe v4}}
{{on chip | Affy GenomeWide 6}}
{{on chip | HumanOmni1Quad}}
{{on chip | Illumina Human 1M}}