{{Rsnum
|rsid=7975232
|Gene=VDR
|Chromosome=12
|position=47845054
|Orientation=plus
|GMAF=0.4959
|Assembly=GRCh38
|GenomeBuild=38.1
|dbSNPBuild=141
|geno1=(A;A)
|geno2=(A;C)
|geno3=(C;C)
|Gene_s=VDR
}}{{ population diversity
| geno1=(A;A)
| geno2=(A;C)
| geno3=(C;C)
| CEU | 37.2 | 39.8 | 23.0
| HCB | 8.0 | 38.0 | 54.0
| JPT | 10.6 | 45.1 | 44.2
| YRI | 35.9 | 48.3 | 15.9
| ASW | 35.1 | 54.4 | 10.5
| CHB | 8.0 | 38.0 | 54.0
| CHD | 11.0 | 42.2 | 46.8
| GIH | 20.8 | 60.4 | 18.8
| LWK | 53.6 | 38.2 | 8.2
| MEX | 15.5 | 56.9 | 27.6
| MKK | 44.9 | 45.5 | 9.6
| TSI | 36.3 | 45.1 | 18.6
| HapMapRevision=28
}}{{PMID Auto
|PMID=19644412
|Title=Polymorphisms in the vitamin D receptor gene and risk of lung cancer
}}

{{PMID Auto
|PMID=19622139
|Title=Association study between vitamin D receptor gene polymorphisms and asthma in the Chinese Han population: a case-control study
|OA=1
}}
{{PMID Auto
|PMID=19499989
|Title=Vitamin D receptor polymorphisms in differentiated thyroid carcinoma
}}

{{PMID Auto
|PMID=19734102
|Title=Vitamin D receptor gene polymorphisms and susceptibility to type 1 diabetes in Crete, Greece
}}
{{PMID Auto
|PMID=19758194
|Title=Association study on two vitamin D receptor gene polymorphisms and vitamin D metabolites in multiple sclerosis
}}

{{PharmGKB
|RSID=rs7975232
|Name_s=VDR:ApaI
|Gene_s=VDR
|Feature=
|Evidence=Web Resource:http://www.pharmgkb.org/search/annotatedGene/vdr/variant.jsp#ImportantVariantInformationforVDR-rs3782905
|Annotation=Well studied, associated with several phenotypes
|Drugs=
|Drug Classes=
|Diseases=
|Curation Level=In-Depth
|PharmGKB Accession ID=PA161145142
}}

{{PMID Auto
|PMID=21548019
|Title=Maternal vitamin D receptor genetic variation contributes to infant birthweight among black mothers
|OA=1
}}

{{PMID Auto
|PMID=22422157
|Title=Vitamin D receptor gene variability as a factor influencing bone mineral density in pediatric patients
}}

{{PMID Auto
|PMID=21951018
|Title=Lack of association of vitamin D receptor gene 3'-haplotypes with psoriasis in Croatian patients.
}}

{{PMID|15651992|OA=1
}} Variants in the vitamin D receptor gene and asthma.

{{PMID|16279845}} Vitamin D receptor polymorphisms are associated with Graves' disease in German and Polish but not in Serbian patients.

{{PMID|16600026|OA=1
}} Asthma families show transmission disequilibrium of gene variants in the vitamin D metabolism and signalling pathway.

{{PMID|16634022}} Polymorphisms in the vitamin D receptor and their associations with risk of schizophrenia and selected anthropometric measures.

{{PMID|17244366|OA=1
}} Vitamin D pathway gene polymorphisms, diet, and risk of postmenopausal breast cancer: a nested case-control study.

{{PMID|17705862|OA=1
}} Optimization of candidate-gene SNP-genotyping by flexible oligonucleotide microarrays; analyzing variations in immune regulator genes of hay-fever samples.

{{PMID|17867381|OA=1
}} Vitamin D receptor gene (VDR) associations with cancer.

{{PMID|17903296|OA=1
}} Genome-wide association with bone mass and geometry in the Framingham Heart Study.

{{PMID|18079052|OA=1
}} Vitamin D receptor polymorphisms and risk of epithelial ovarian cancer.

{{PMID|18086759}} Vitamin D receptor gene polymorphisms and epithelial ovarian cancer risk.

{{PMID|18086783|OA=1
}} CDX2 VDR polymorphism and colorectal cancer.

{{PMID|18205735}} Association of vitamin D receptor gene polymorphisms in Chinese patients with generalized aggressive periodontitis.

{{PMID|18279374}} Association of vitamin D receptor gene 3'-variants with Hashimoto's thyroiditis in the Croatian population.

{{PMID|18361940}} Lack of association of vitamin D receptor gene polymorphisms with susceptibility to type 1 diabetes mellitus in the Portuguese population.

{{PMID|18709640}} Modification of the inverse association between dietary vitamin D intake and colorectal cancer risk by a FokI variant supports a chemoprotective action of Vitamin D intake mediated through VDR binding.

{{PMID|18849534}} Association of genetic polymorphisms in vitamin D receptor gene and susceptibility to sporadic prostate cancer.

{{PMID|19255064|OA=1
}} Vitamin D-related genes, serum vitamin D concentrations and prostate cancer risk.

{{PMID|19454612|OA=1
}} Vitamin D pathway gene variants and prostate cancer risk.

{{PMID|19615888|OA=1
}} Vitamin D receptor gene polymorphisms, serum 25-hydroxyvitamin D levels, and melanoma: UK case-control comparisons and a meta-analysis of published VDR data.

{{PMID|19682379|OA=1
}} TagSNP transferability and relative loss of variability prediction from HapMap to an admixed population.

{{PMID|19693091}} Vitamin D receptor gene polymorphisms and distinct clinical phenotypes of hepatitis B carriers in Taiwan.

{{PMID|19783860}} A rare haplotype of the vitamin D receptor gene is protective against diabetic nephropathy.

{{PMID|19852851|OA=1
}} Asthma and genes encoding components of the vitamin D pathway.

{{PMID|19956101|OA=1
}} Overview of the Rapid Response data.

{{PMID|19956103|OA=1
}} Association analyses of the vitamin D receptor gene in 1654 families with type I diabetes.

{{PMID|19956106|OA=1
}} Analysis of 19 genes for association with type I diabetes in the Type I Diabetes Genetics Consortium families.

{{PMID|19956109|OA=1
}} The Type I Diabetes Genetics Consortium 'Rapid Response' family-based candidate gene study: strategy, genes selection, and main outcome.

{{PMID|20565774|OA=1
}} Population based allele frequencies of disease associated polymorphisms in the Personalized Medicine Research Project.

{{PMID|20572305|OA=1
}} Vitamin D receptor gene polymorphisms and hepatocellular carcinoma in alcoholic cirrhosis.

{{PMID|20585998}} Variation in the vitamin D receptor gene is not associated with risk of colorectal cancer in the Czech Republic.

{{PMID|21168462|OA=1
}} Vitamin D receptor gene methylation is associated with ethnicity, tuberculosis, and TaqI polymorphism.

{{PMID|21198767}} BsmI, TaqI, ApaI, and FokI polymorphisms in the vitamin D receptor gene and periodontitis: a meta-analysis of 15 studies including 1338 cases and 1302 controls.

{{PMID|21358824|OA=1
}} Prostate cancer susceptibility Loci identified on chromosome 12 in African Americans.

{{PMID|21818054}} Common variation in the vitamin D receptor gene and risk of inflammatory bowel disease in an Irish case-control study.

{{PMID|22151003}} Combined effect of 25-OH vitamin D plasma levels and genetic vitamin D receptor (NR 1I1) variants on fibrosis progression rate in HCV patients.

{{PMID|22170372|OA=1
}} Vitamin D receptor and megalin gene polymorphisms and their associations with longitudinal cognitive change in US adults.

{{PMID|22193625}} Association between vitamin D receptor gene polymorphisms and bone mineral density in Chinese women.

{{PMID|22390397}} Associations between polymorphisms related to calcium metabolism and human height: the Tromso Study.

{{PMID|22576141|OA=1
}} No association of vitamin D metabolism-related polymorphisms and melanoma risk as well as melanoma prognosis: a case-control study.

{{PMID Auto
|PMID=23034014
|Title=Association of vitamin D receptor gene polymorphisms with severe atopic dermatitis in adults
}}

{{GET Evidence
|impact=pharmacogenetic
|qualified_impact=Insufficiently evaluated pharmacogenetic
|inheritance=unknown
|quality_scores=Array
|dbsnp_id=rs7975232
|overall_frequency_n=6062
|overall_frequency_d=10754
|overall_frequency=0.563697
|n_genomes=42
|n_genomes_annotated=0
|n_haplomes=58
|n_articles=0
|n_articles_annotated=0
|in_pharmgkb=Y
|autoscore=1
|webscore=N
}}

{{PMID Auto
|PMID=22681928
|Title=Vitamin D deficiency in girls from South Brazil: a cross-sectional study on prevalence and association with vitamin D receptor gene variants
|OA=1
}}

{{PMID Auto
|PMID=23262379
|Title=Vitamin D receptor (VDR) Polymorphisms and Risk of Ovarian Cancer in Caucasian and African American Women
}}

{{PMID Auto
|PMID=23418495
|Title=1,25-Dihydroxyvitamin D and the Vitamin D Receptor Gene Polymorphism Apa1 Influence Bone Mineral Density in Primary Hyperparathyroidism
|OA=1
}}

{{PMID Auto
|PMID=23639864
|Title=Otosclerosis and vitamin D receptor gene polymorphism
}}

{{PMID Auto
|PMID=23841669
|Title=VDR gene polymorphisms, interaction with smoking, and risk of periodontal disease in Japanese women: the Kyushu Okinawa Maternal and Child Health Study
}}

{{PMID Auto
|PMID=23979900
|Title=Association analysis of vitamin D receptor gene polymorphisms and bone mineral density in postmenopausal Mexican-Mestizo women
}}

{{PMID Auto
|PMID=24073221
|Title=Influence of Vitamin D-Related Gene Polymorphisms (CYP27B and VDR) on the Response to Interferon/Ribavirin Therapy in Chronic Hepatitis C
|OA=1
}}

{{PMID Auto
|PMID=24224838
|Title=Polymorphisms in the Vitamin D Receptor Gene and Risk of Primary Biliary Cirrhosis: a meta-analysis
}}

{{PMID Auto
|PMID=22522591
|Title=Genetic variations in bile acid homeostasis are not overrepresented in alcoholic cirrhosis compared to patients with heavy alcohol abuse and absent liver disease.
}}

{{PMID Auto
|PMID=22551951
|Title=Allelic variations in the vitamin D receptor gene, insulin secretion and parents' heights are independently associated with height in obese children and adolescents.
}}

{{PMID Auto
|PMID=22867716
|Title=Vitamin D receptor polymorphisms and breast cancer risk in a high-incidence population: a pilot study.
}}

{{PMID Auto
|PMID=22917542
|Title=Association of vitamin D receptor gene polymorphisms with clinical outcomes of dengue virus infection.
}}

{{PMID Auto
|PMID=23065277
|Title=Vitamin D receptor gene BsmI, FokI, ApaI and TaqI polymorphisms and the risk of systemic lupus erythematosus.
|OA=1
}}

{{PMID Auto
|PMID=23065592
|Title=Polymorphisms in the vitamin D receptor gene and risk of autoimmune thyroid diseases: a meta-analysis.
}}

{{PMID Auto
|PMID=23070913
|Title=Association of vitamin D binding protein polymorphism with long-term kidney allograft survival in Hispanic kidney transplant recipients.
}}

{{PMID Auto
|PMID=24853028
|Title=Association of vitamin D receptor gene polymorphism with the risk of systemic lupus erythematosus
}}

{{PMID Auto
|PMID=24894441
|Title=Significance of Vitamin D Receptor Gene Polymorphisms for Risk of Hepatocellular Carcinoma in Chronic Hepatitis C
}}

{{PMID Auto
|PMID=24927719
|Title=Interrelation between genotypes of the vitamin D receptor gene and serum sex hormone concentrations in the Polish elderly population: the PolSenior study
}}

{{PMID Auto
|PMID=24996287
|Title=Association of vitamin D receptor FokI and ApaI polymorphisms with lung cancer risk in Tunisian population
}}

{{PMID Auto
|PMID=25000366
|Title=Association of vitamin D receptor gene polymorphism with the urine calcium level in nephrolithiasis patients
}}
{{on chip | 23andMe v1}}
{{on chip | 23andMe v2}}
{{on chip | 23andMe v3}}
{{on chip | 23andMe v4}}
{{on chip | Illumina Human 1M}}