{{Rsnum
|rsid=7977109
|Gene=NOS1
|Chromosome=12
|position=117292535
|Orientation=plus
|GMAF=0.3641
|Assembly=GRCh38
|GenomeBuild=38.1
|dbSNPBuild=141
|geno1=(A;A)
|geno2=(A;G)
|geno3=(G;G)
|effect1=
|effect2=
|effect3=
|Gene_s=NOS1
}}{{ population diversity
| geno1=(A;A)
| geno2=(A;G)
| geno3=(G;G)
| CEU | 19.5 | 59.3 | 21.2
| HCB | 53.3 | 39.4 | 7.3
| JPT | 51.3 | 34.5 | 14.2
| YRI | 81.6 | 17.0 | 1.4
| ASW | 63.2 | 31.6 | 5.3
| CHB | 53.3 | 39.4 | 7.3
| CHD | 59.6 | 35.8 | 4.6
| GIH | 49.5 | 42.6 | 7.9
| LWK | 85.5 | 13.6 | 0.9
| MEX | 12.1 | 55.2 | 32.8
| MKK | 68.4 | 29.0 | 2.6
| TSI | 19.8 | 46.5 | 33.7
| HapMapRevision=28
}}

After scanning a region of chromosome 12 previously linked to [[restless legs syndrome]] in ~900 patients, German investigators found SNPs within the [[NOS1]] gene to be most associated with the syndrome. SNP [[rs7977109]] yielded an odds ratio of 0.76 (CI: 0.64 -0.90, p=-.002). The risk allele is said to be defined in Supplementary materials available online, but they aren't. Furthermore, the significant association seen for this SNP and one other ([[rs693534]]) are in opposite directions in the explorative versus the replication populations.{{PMID|18058820}}

{{PMID|20401335|OA=1
}} Sickle Cell Disease in the Post Genomic Era: A Monogenic Disease with a Polygenic Phenotype.

{{on chip | 23andMe v3}}
{{on chip | 23andMe v4}}
{{on chip | Affy GenomeWide 6}}
{{on chip | FTDNA2}}
{{on chip | HumanOmni1Quad}}