{{Rsnum
|rsid=7993214
|Gene=COG6
|Chromosome=13
|position=39776775
|Orientation=plus
|GMAF=0.2952
|Assembly=GRCh38
|GenomeBuild=38.1
|dbSNPBuild=141
|geno1=(C;C)
|geno2=(C;T)
|geno3=(T;T)
|effect1=
|effect2=
|effect3=
|Gene_s=COG6
}}{{ population diversity
| geno1=(C;C)
| geno2=(C;T)
| geno3=(T;T)
| CEU | 35.4 | 46.9 | 17.7
| HCB | 58.6 | 38.3 | 3.0
| JPT | 59.3 | 38.1 | 2.7
| YRI | 50.3 | 38.8 | 10.9
| ASW | 33.3 | 49.1 | 17.5
| CHB | 58.6 | 38.3 | 3.0
| CHD | 62.6 | 31.8 | 5.6
| GIH | 51.5 | 37.6 | 10.9
| LWK | 41.3 | 45.0 | 13.8
| MEX | 55.2 | 39.7 | 5.2
| MKK | 40.6 | 51.6 | 7.7
| TSI | 51.0 | 46.1 | 2.9
| HapMapRevision=28
}}

{{PMID|18369459|OA=1
}} [[rs7993214]] was a significant SNP associated with risk for [[psoriasis]] in a large US/UK study.

{{GWAS Summary
|SNP=rs7993214
|PubMedID=18369459
|Condition=Psoriasis
|Gene=COG6
|Risk Allele=
|pValue=2.00E-006
|OR=1.41
|95CI=1.22-1.61
|OA=1
}}

{{PharmGKB
|RSID=rs7993214
|Name_s=
|Gene_s=-
|Feature=
|Evidence=PubMed ID:18369459; Web Resource:http://www.genome.gov/gwastudies/
|Annotation=GWAS results: A genome-wide association study of psoriasis and psoriatic arthritis identifies new disease Loci (Initial Sample Size: 218 cases, 519 controls; Replication Sample Size: 1,153 cases, 1,217 controls). This variant is associated with Psoriasis.
|Drugs=
|Drug Classes=
|Diseases=Psoriasis
|Curation Level=Non-Curated
|PharmGKB Accession ID=PA162356389
}}

{{PMID Auto
|PMID=20722033
|Title=The susceptibility loci juvenile idiopathic arthritis shares with other autoimmune diseases extend to PTPN2, COG6, and ANGPT1.
|OA=1
}}

{{GET Evidence
|impact=pathogenic
|qualified_impact=Insufficiently evaluated pathogenic
|inheritance=unknown
|quality_scores=Array
|dbsnp_id=rs7993214
|overall_frequency_n=94
|overall_frequency_d=128
|overall_frequency=0.734375
|n_genomes=51
|n_genomes_annotated=0
|n_haplomes=83
|n_articles=0
|n_articles_annotated=0
|in_gwas=Y
|in_pharmgkb=Y
|autoscore=2
|webscore=N
}}

{{on chip | 23andMe v1}}
{{on chip | 23andMe v2}}
{{on chip | 23andMe v3}}
{{on chip | 23andMe v4}}
{{on chip | HumanOmni1Quad}}
{{on chip | Illumina Human 1M}}