{{Rsnum
|rsid=8007267
|Gene=GCH1
|Chromosome=14
|position=54912273
|Orientation=plus
|GMAF=0.2874
|Assembly=GRCh38
|GenomeBuild=38.1
|dbSNPBuild=141
|geno1=(C;C)
|geno2=(C;T)
|geno3=(T;T)
}}{{ population diversity
| geno1=(C;C)
| geno2=(C;T)
| geno3=(T;T)
| CEU | 58.0 | 33.9 | 8.0
| HCB | 72.3 | 25.5 | 2.2
| JPT | 65.5 | 29.2 | 5.3
| YRI | 7.5 | 41.5 | 51.0
| ASW | 17.5 | 49.1 | 33.3
| CHB | 72.3 | 25.5 | 2.2
| CHD | 78.0 | 20.2 | 1.8
| GIH | 65.3 | 32.7 | 2.0
| LWK | 18.2 | 47.3 | 34.5
| MEX | 56.9 | 41.4 | 1.7
| MKK | 27.6 | 45.5 | 26.9
| TSI | 77.5 | 20.6 | 2.0
| HapMapRevision=28
}}GTP cyclohydrolase and [[tetrahydrobiopterin]] regulate pain sensitivity and persistence. T allele associated with higher tolerance to pain.{{PMID|17057711}}

Do genetic predictors of pain sensitivity associate with persistent widespread pain? T allele associated with higher pain tolerance.{{PMID|19775452|OA=1
}}

[[GCH1]] haplotype determines vascular and plasma biopterin availability in coronary artery disease effects on vascular superoxide production and endothelial function. Part of a haplotype, [[rs10483639]](C)-[[rs3783641]](A)-[[rs8007267]](T), associated with lower levels of [[tetrahydrobiopterin]].{{PMID|18598896|OA=1
}}

{{PMID Auto
|PMID=17343757
|Title=Lack of influence of GTP cyclohydrolase gene (GCH1) variations on pain sensitivity in humans.
|OA=1
}}

{{PMID Auto
|PMID=17363416
|Title=Reliable screening for a pain-protective haplotype in the GTP cyclohydrolase 1 gene (GCH1) through the use of 3 or fewer single nucleotide polymorphisms.
}}

{{PMID Auto
|PMID=19014702
|Title=Does the pain-protective GTP cyclohydrolase haplotype significantly alter the pattern or severity of pain in humans with chronic pancreatitis?
|OA=1
}}

{{PMID Auto
|PMID=19081190
|Title=Polymorphisms in the GTP cyclohydrolase gene (GCH1) are associated with ratings of capsaicin pain.
|OA=1
}}

{{PMID Auto
|PMID=19751821
|Title=Oxidative risk for atherothrombotic cardiovascular disease.
|OA=1
}}

{{PMID Auto
|PMID=20633294
|Title=Different SNP combinations in the GCH1 gene and use of labor analgesia.
|OA=1
}}

{{PMID Auto
|PMID=20842020
|Title=Catecholamine-o-methyltransferase polymorphisms are associated with postoperative pain intensity.
}}

{{PMID Auto
|PMID=23059057
|Title=A GCH1 haplotype and risk of neural tube defects in the National Birth Defects Prevention Study
|OA=1
}}

{{PMID Auto
|PMID=22770721
|Title=GTP cyclohydrolase 1 gene haplotypes as predictors of SSRI response in Japanese patients with major depressive disorder
}}

{{on chip | 23andMe v1}}
{{on chip | 23andMe v2}}
{{on chip | 23andMe v3}}
{{on chip | 23andMe v4}}
{{on chip | Illumina Human 1M}}
{{on chip | NatGeo2}}