{{Rsnum
|rsid=8023462
|Gene=CHRNA3
|Chromosome=15
|position=78622392
|Orientation=plus
|GMAF=0.2406
|Assembly=GRCh38
|GenomeBuild=38.1
|dbSNPBuild=141
|geno1=(C;C)
|geno2=(C;T)
|geno3=(T;T)
|Gene_s=CHRNA3
}}The (T;T) genotype (as published) of [[rs8023462]] was calculated to represent a hazard ratio of 1.35 (CI: 1.08-1.70) for initiation of tobacco and alcohol use at an earlier age than average. A linked SNP also in the [[A5A3B4]] gene, [[rs1948]], showed similiar association. {{PMID|18163978|OA=1
}}

{{PMID Auto
|PMID=18165968
|Title=Identification of pharmacogenetic markers in smoking cessation therapy.
|OA=1
}}

{{PMID Auto
|PMID=18571741
|Title=Genetic variability in nicotinic acetylcholine receptors and nicotine addiction: converging evidence from human and animal research.
|OA=1
}}

{{PMID Auto
|PMID=19330903
|Title=Gene by smoking interaction in hypertension: identification of a major quantitative trait locus on chromosome 15q for systolic blood pressure in Mexican-Americans.
|OA=1
}}

{{PMID Auto
|PMID=19492010
|Title=The genetic components of alcohol and nicotine co-addiction: from genes to behavior.
|OA=1
}}

{{PMID Auto
|PMID=23872218
|Title=Functional characterization of SNPs in CHRNA3/B4 intergenic region associated with drug behaviors
}}

{{on chip | 23andMe v3}}
{{on chip | 23andMe v4}}
{{on chip | FTDNA2}}
{{on chip | HumanOmni1Quad}}