{{Rsnum
|rsid=80265967
|Gene=SOD1
|Chromosome=21
|position=31667290
|Orientation=plus
|GMAF=0.0009183
|Assembly=GRCh38
|GenomeBuild=38.1
|dbSNPBuild=141
|geno1=(A;A)
|geno2=(A;C)
|geno3=(C;C)
|Gene_s=SOD1
}}[[rs80265967]], also known as D90A or less commonly Asp90Ala, is a mutation in the superoxide dismutase 1 [[SOD1]] gene.

[[rs80265967]](C) has been associated with familial (inherited) forms of [[amyotrophic lateral sclerosis]], in both heterozygous dominant and homozygous recessive forms. {{PMID|8446170}}

{{omim
|id=147450
|rsnum=80265967
|variant=0015
}}{{ClinVar
|rsid=80265967
|Reversed=0
|FwdREF=A
|FwdALT=C
|REF=A
|ALT=C
|RSPOS=33039603
|CHROM=21
|GMAF=0.0009
|dbSNPBuildID=131
|SSR=0
|SAO=1
|VP=0x050260000000040416110100
|GENEINFO=SOD1:6647
|GENE_NAME=SOD1
|GENE_ID=6647
|WGT=0
|VC=SNV
|CLNALLE=1
|CLNHGVS=NC_000021.8:g.33039603A>C
|CLNSRC=OMIM Allelic Variant
|CLNORIGIN=1
|CLNSRCID=147450.0015
|CLNSIG=5
|CLNCUI=C1862939
|CLNDBN=Amyotrophic lateral sclerosis type 1; Amyotrophic lateral sclerosis 1, autosomal recessive
|Disease=Amyotrophic lateral sclerosis type 1; Amyotrophic lateral sclerosis 1
|CLNACC=RCV000015888.24; RCV000015889.24
|Tags=PM;S3D;VLD;HD;KGPhase1;KGPROD;OTHERKG;LSD;OM
|CAF=0.9991; 0.0009183
|CLNDSDB=GeneReviews:MedGen:OMIM:Orphanet
|CLNDSDBID=NBK1450:C1862939:105400:803
|COMMON=0
}}