{{Rsnum
|rsid=8028689
|Gene=HERC2
|Chromosome=15
|position=28243742
|Orientation=plus
|GMAF=0.2378
|Assembly=GRCh38
|GenomeBuild=38.1
|dbSNPBuild=141
|geno1=(C;C)
|geno2=(C;T)
|geno3=(T;T)
|Gene_s=HERC2
}}{{ population diversity
| geno1=(C;C)
| geno2=(C;T)
| geno3=(T;T)
| CEU | 0.0 | 10.6 | 89.4
| HCB | 19.7 | 46.7 | 33.6
| JPT | 17.7 | 44.2 | 38.1
| YRI | 23.1 | 46.3 | 30.6
| ASW | 12.3 | 43.9 | 43.9
| CHB | 19.7 | 46.7 | 33.6
| CHD | 18.3 | 53.2 | 28.4
| GIH | 6.9 | 44.6 | 48.5
| LWK | 23.6 | 48.2 | 28.2
| MEX | 1.7 | 19.0 | 79.3
| MKK | 9.0 | 41.0 | 50.0
| TSI | 2.9 | 29.4 | 67.6
| HapMapRevision=28
}}[[rs8028689]] is part of a haplotype spanning 166kB on chromosome 15, defined by 13 SNPs listed below, found in 97% of all Caucasians with blue eyes. In this haplotype, variations in [[rs1129038]] and [[rs12913832]] are relatively common in Caucasians though rare among other ethnic groups.{{PMID|18172690}}

The "h-1" haplotype found in homozygous state in 97% of individuals with blue [[eye color]] is composed as follows {{PMID|18172690}}:

[[rs4778241]](C)<br>
[[rs1129038]](A)<br>
[[rs12593929]](A)<br>
[[rs12913832]](G)<br>
[[rs7183877]](C)<br>
[[rs3935591]](G)<br>
[[rs7170852]](A)<br>
[[rs2238289]](T)<br>
[[rs3940272]](C)<br>
[[rs8028689]](T)<br>
[[rs2240203]](A)<br>
[[rs11631797]](G)<br>
[[rs916977]](G)<br>

{{PMID Auto
|PMID=18252221
|Title=Three genome-wide association studies and a linkage analysis identify HERC2 as a human iris color gene.
|OA=1
}}

{{PMID Auto
|PMID=18483556
|Title=A genome-wide association study identifies novel alleles associated with hair color and skin pigmentation.
|OA=1
}}

{{PMID Auto GWAS
  |PMID=23502783
  |Trait=Multiple myeloma (IgH translocation)
  |Title=The CCND1 c.870G>A polymorphism is a risk factor for t(11;14)(q13;q32) multiple myeloma.
  |RiskAllele=G
  |Pval=7E-6
  |OR=1.65
  |ORtxt=[1.33-2.05]
  }}

{{on chip | 23andMe v1}}
{{on chip | 23andMe v2}}
{{on chip | 23andMe v3}}
{{on chip | 23andMe v4}}
{{on chip | Affy GenomeWide 6}}
{{on chip | FTDNA2}}
{{on chip | FTDNA}}
{{on chip | HumanOmni1Quad}}
{{on chip | Illumina Human 1M}}