{{Rsnum
|rsid=80338908
|Chromosome=9
|Orientation=plus
|geno1=(C;C)
|geno2=(C;T)
|geno3=(T;T)
|Gene=TEK
|position=27206762
|Assembly=GRCh38
|GenomeBuild=38.1
|dbSNPBuild=141
|Gene_s=TEK
}}{{omim
|id=600221
|rsnum=80338908
|variant=0001
}}{{ClinVar
|rsid=80338908
|Reversed=0
|FwdREF=C
|FwdALT=T
|REF=C
|ALT=T
|RSPOS=27206760
|CHROM=9
|dbSNPBuildID=131
|SSR=0
|SAO=1
|VP=0x050168000000000002110100
|GENEINFO=TEK:7010
|GENE_NAME=TEK
|GENE_ID=7010
|WGT=0
|VC=SNV
|CLNALLE=1
|CLNHGVS=NC_000009.11:g.27206760C>T
|CLNSRC=GeneReviews; OMIM Allelic Variant
|CLNORIGIN=1
|CLNSRCID=NBK1967; 600221.0001
|CLNSIG=5
|CLNCUI=C1838437; C1838437
|CLNDBN=Multiple Cutaneous and Mucosal Venous Malformations
|Disease=Multiple Cutaneous and Mucosal Venous Malformations
|CLNACC=RCV000009876.1
|Tags=PM;PMC;SLO;OTHERKG;LSD;OM
|CLNDSDB=GeneReviews:MedGen:OMIM:Orphanet
|CLNDSDBID=NBK1967:C1838437:600195:2451
}}{{PMID|8415706|OA=1
}} Tie-1 and tie-2 define another class of putative receptor tyrosine kinase genes expressed in early embryonic vascular system.

{{PMID|8980225}} Vascular dysmorphogenesis caused by an activating mutation in the receptor tyrosine kinase TIE2.

{{PMID|9926914}} Endothelial receptor tyrosine kinases activate the STAT signaling pathway: mutant Tie-2 causing venous malformations signals a distinct STAT activation response.
{{PMID Auto
|PMID=23566851
|Title=Association study between of Tie2/angiopoietin-2 and VEGF/KDR pathway gene polymorphisms and vascular malformations
}}