{{Rsnum
|rsid=80338939
|Chromosome=13
|Orientation=minus
|geno1=(-;-)
|geno2=(-;G)
|geno3=(G;G)
|Gene=GJB2
|position=20189547
|Assembly=GRCh38
|GenomeBuild=38.1
|dbSNPBuild=141
|Gene_s=GJB2
}}

[[rs80338939]], also known as 35delG or in some cases 30delG, is a SNP in the [[GJB2]] gene. This variant is the most common one associated (when present in two copies) with autosomal recessive nonsyndromic [[hearing loss]], i.e. [[deafness]].

Note: In 23andMe data, this SNP is referred to as i4000434.

{{omim
|id=121011
|rsnum=80338939
|variant=0005
}}{{ClinVar
|rsid=80338939
|Reversed=1
|FwdREF=G
|FwdALT=
|REF=AC
|ALT=A
|RSPOS=20763685
|CHROM=13
|dbSNPBuildID=131
|SSR=0
|SAO=1
|VP=0x050368000000040102110200
|GENEINFO=GJB2:2706
|GENE_NAME=GJB2
|GENE_ID=2706
|WGT=0
|VC=DIV
|CLNALLE=1
|CLNHGVS=NC_000013.10:g.20763686delC
|CLNSRC=GeneReviews; OMIM Allelic Variant
|CLNORIGIN=0
|CLNSRCID=NBK1272; 121011.0005
|CLNSIG=5
|CLNCUI=C2673759; C2673760; C1844678
|CLNDBN=Deafness, autosomal recessive 1A; Deafness, digenic, GJB2/GJB6; Hereditary hearing loss and deafness; not provided
|Disease=Deafness; Hereditary hearing loss and deafness; not provided
|CLNACC=RCV000018527.27; RCV000018528.27; RCV000037843.1; RCV000080373.1
|Tags=RV;PM;PMC;S3D;SLO;VLD;GNO;OTHERKG;LSD;OM
|CLNDSDB=GeneReviews:GeneReviews:MedGen:OMIM:Orphanet; MedGen; GeneReviews:MedGen:SNOMED_CT
|CLNDSDBID=NBK1272:NBK1434:C2673759:220290:90636; C2673760; NBK1434:C0236038:95827002
}}{{PMID Auto
|PMID=125225
|Title=Trisomy 21 and trisomy 18 in half-siblings.
}}

{{PMID Auto
|PMID=9328482
|Title=Two different connexin 26 mutations in an inbred kindred segregating non-syndromic recessive deafness: implications for genetic studies in isolated populations.
}}

{{PMID Auto
|PMID=10633133
|Title=Prevalent connexin 26 gene (GJB2) mutations in Japanese.
|OA=1
}}

{{PMID Auto
|PMID=11313751
|Title=On the origin and frequency of the 35delG allele in GJB2-linked deafness in Europe.
}}

{{PMID Auto
|PMID=12176036
|Title=Hearing loss: frequency and functional studies of the most common connexin26 alleles.
}}

{{PMID Auto
|PMID=16088916
|Title=High prevalence of the W24X mutation in the gene encoding connexin-26 (GJB2) in Spanish Romani (gypsies) with autosomal recessive non-syndromic hearing loss.
}}

{{PMID Auto
|PMID=9819448
|Title=Mutations in the connexin 26 gene (GJB2) among Ashkenazi Jews with nonsyndromic recessive deafness.
}}

{{PMID Auto
|PMID=10508996
|Title=High frequency of the deafness-associated 167delT mutation in the connexin 26 (GJB2) gene in Israeli Ashkenazim.
}}

{{PMID Auto
|PMID=10982182
|Title=The prevalence and expression of inherited connexin 26 mutations associated with nonsyndromic hearing loss in the Israeli population.
}}

{{PMID Auto
|PMID=11386851
|Title=Nonradioactive detection of the common Connexin 26 167delT and 35delG mutations and frequencies among Ashkenazi Jews.
}}

{{PMID Auto
|PMID=11668644
|Title=A deletion mutation in GJB6 cooperating with a GJB2 mutation in trans in non-syndromic deafness: A novel founder mutation in Ashkenazi Jews.
}}