{{Rsnum
|rsid=80356664
|Chromosome=11
|Orientation=minus
|geno1=(A;A)
|geno2=(A;G)
|geno3=(G;G)
|Gene=INS
|position=2160878
|Assembly=GRCh38
|GenomeBuild=38.1
|dbSNPBuild=141
|Gene_s=INS,INS-IGF2
}}{{omim
|id=176730
|rsnum=80356664
|variant=0008
}}{{ClinVar
|rsid=80356664
|Reversed=1
|FwdREF=G
|FwdALT=A,C
|REF=C
|ALT=G,T
|RSPOS=2182108
|CHROM=11
|dbSNPBuildID=132
|SSR=0
|SAO=1
|VP=0x050368000000000002110100
|GENEINFO=INS:3630; INS-IGF2:723961
|GENE_NAME=INS; INS-IGF2
|GENE_ID=3630; 723961
|WGT=0
|VC=SNV
|CLNALLE=1; 2
|CLNHGVS=NC_000011.9:g.2182108C>G; NC_000011.9:g.2182108C>T
|CLNSRC=GeneReviews; UniProtKB (variants); OMIM Allelic Variant
|CLNORIGIN=0; 1
|CLNSRCID=NBK1447; VAR_063725; 176730.0008; VAR_063726
|CLNSIG=5
|CLNCUI=C1833104
|CLNDBN=Permanent neonatal diabetes mellitus; Neonatal diabetes mellitus
|Disease=Permanent neonatal diabetes mellitus; Neonatal diabetes mellitus
|CLNACC=RCV000020213.2; RCV000020212.26; RCV000030072.1
|Tags=RV;PM;PMC;S3D;SLO;OTHERKG;LSD;OM
|CLNDSDB=GeneReviews:MedGen:OMIM:Orphanet:Orphanet; MedGen:SNOMED_CT
|CLNDSDBID=NBK1447:C1833104:606176:79134:99885; C0158981:49817004
}}{{PMID Auto
|PMID=17855560
|Title=Insulin gene mutations as a cause of permanent neonatal diabetes.
|OA=1
}}

{{PMID Auto
|PMID=17855
|Title=Limitations of present drug therapy of cardiac arrhythmias--a review.
}}

{{PMID Auto
|PMID=18162506
|Title=Insulin mutation screening in 1,044 patients with diabetes: mutations in the INS gene are a common cause of neonatal diabetes but a rare cause of diabetes diagnosed in childhood or adulthood.
}}

{{PMID Auto
|PMID=18436707
|Title=Neonatal diabetes mellitus.
|OA=1
}}

{{PMID Auto
|PMID=18840770
|Title=Insulin gene mutations as cause of diabetes in children negative for five type 1 diabetes autoantibodies.
|OA=1
}}

{{PMID Auto
|PMID=20034470
|Title=Mutant proinsulin proteins associated with neonatal diabetes are retained in the endoplasmic reticulum and not efficiently secreted.
|OA=1
}}

{{PMID Auto
|PMID=20938745
|Title=Clinical and molecular genetics of neonatal diabetes due to mutations in the insulin gene.
|OA=1
}}{{PMID Auto
|PMID=17047922
|Title=Improved motor development and good long-term glycaemic control with sulfonylurea treatment in a patient with the syndrome of intermediate developmental delay, early-onset generalised epilepsy and neonatal diabetes associated with the V59M mutation in the KCNJ11 gene.
}}

{{PMID Auto
|PMID=18171712
|Title=Heterozygous missense mutations in the insulin gene are linked to permanent diabetes appearing in the neonatal period or in early infancy: a report from the French ND (Neonatal Diabetes) Study Group.
}}