{{Rsnum
|rsid=8042374
|Gene=CHRNA3
|Chromosome=15
|position=78615690
|Orientation=plus
|GMAF=0.4385
|Assembly=GRCh38
|GenomeBuild=38.1
|dbSNPBuild=141
|geno1=(A;A)
|geno2=(A;G)
|geno3=(G;G)
|Gene_s=CHRNA3
}}{{ population diversity
| geno1=(A;A)
| geno2=(A;G)
| geno3=(G;G)
| CEU | 63.4 | 33.0 | 3.6
| HCB | 8.9 | 35.6 | 55.6
| JPT | 4.6 | 40.7 | 54.6
| YRI | 42.7 | 44.8 | 12.6
| ASW | 50.0 | 33.9 | 16.1
| CHB | 8.9 | 35.6 | 55.6
| CHD | 8.5 | 41.5 | 50.0
| GIH | 29.0 | 47.0 | 24.0
| LWK | 29.6 | 54.6 | 15.7
| MEX | 22.4 | 46.6 | 31.0
| MKK | 51.0 | 43.9 | 5.2
| TSI | 59.4 | 34.7 | 5.9
| HapMapRevision=28
}}{{PMID|18978787|OA=1
}} [[lung cancer]] [[rs8042374]] P = 7.75 x 10(-12)

{{omim
|desc=LUNG CANCER SUSCEPTIBILITY 2; LNCR2
|id=612052
|rsnum=8042374
}}

{{PharmGKB
|RSID=rs8042374
|Name_s=
|Gene_s=CHRNA3
|Feature=
|Evidence=PubMed ID:18978787; Web Resource:http://www.genome.gov/gwastudies/
|Annotation=GWAS results: Common 5p15.33 and 6p21.33 variants influence lung cancer risk. (Initial Sample Size: 1,952 cases, 1,438 controls; Replication Sample Size: 7,579 cases, 8,236 controls); (Region: 15q25.1; Reported Gene(s): NR; Risk Allele: rs8042374-?); (p-value= 7.99999999999999E-12).This variant is associated with Lung cancer.
|Drugs=
|Drug Classes=
|Diseases=Lung Neoplasms
|Curation Level=Non-Curated
|PharmGKB Accession ID=PA164740767
}}

{{PharmGKB
|RSID=rs8042374
|Name_s=
|Gene_s=CHRNA3
|Feature=
|Evidence=PubMed ID:18978787
|Annotation=In a GWAS this variant 15q25.1 was associatd with lung cancer risk.
|Drugs=
|Drug Classes=
|Diseases=Lung Neoplasms
|Curation Level=Curated
|PharmGKB Accession ID=PA162360101
}}

{{PMID Auto
|PMID=18519524
|Title=Variants in nicotinic receptors and risk for nicotine dependence.
|OA=1
}}

{{PMID Auto
|PMID=19654303
|Title=Deciphering the impact of common genetic variation on lung cancer risk: a genome-wide association study.
|OA=1
}}

{{PMID Auto
|PMID=19706762
|Title=The CHRNA5-CHRNA3-CHRNB4 nicotinic receptor subunit gene cluster affects risk for nicotine dependence in African-Americans and in European-Americans.
|OA=1
}}

{{PMID Auto
|PMID=19955392
|Title=Role of 5p15.33 (TERT-CLPTM1L), 6p21.33 and 15q25.1 (CHRNA5-CHRNA3) variation and lung cancer risk in never-smokers.
}}

{{GET Evidence
|impact=pathogenic
|qualified_impact=Insufficiently evaluated pathogenic
|inheritance=unknown
|quality_scores=Array
|dbsnp_id=rs8042374
|overall_frequency_n=45
|overall_frequency_d=128
|overall_frequency=0.351562
|n_genomes=35
|n_genomes_annotated=0
|n_haplomes=45
|n_articles=1
|n_articles_annotated=0
|in_gwas=Y
|in_pharmgkb=Y
|autoscore=2
|webscore=N
}}

{{on chip | 23andMe v1}}
{{on chip | 23andMe v2}}
{{on chip | 23andMe v3}}
{{on chip | 23andMe v4}}
{{on chip | Illumina Human 1M}}