{{Rsnum
|rsid=8050136
|Gene=FTO
|Chromosome=16
|position=53782363
|Orientation=plus
|GMAF=0.3384
|Assembly=GRCh38
|GenomeBuild=38.1
|dbSNPBuild=141
|geno1=(A;A)
|geno2=(A;C)
|geno3=(C;C)
|Gene_s=FTO
}}{{ population diversity
| geno1=(A;A)
| geno2=(A;C)
| geno3=(C;C)
| CEU | 17.7 | 56.6 | 25.7
| HCB | 2.2 | 23.4 | 74.5
| JPT | 2.7 | 31.9 | 65.5
| YRI | 21.8 | 46.9 | 31.3
| ASW | 24.6 | 43.9 | 31.6
| CHB | 2.2 | 23.4 | 74.5
| CHD | 2.8 | 26.4 | 70.8
| GIH | 6.9 | 36.6 | 56.4
| LWK | 20.0 | 52.7 | 27.3
| MEX | 1.7 | 37.9 | 60.3
| MKK | 25.6 | 51.3 | 23.1
| TSI | 23.5 | 43.1 | 33.3
| HapMapRevision=28
}}
This SNP is in a linkage block in the [[FTO]] gene with [[rs1121980]]; see [[rs1121980]] for the association of this block with early onset [[obesity]] since it showed the strongest association.{{PMID|18159244|OA=1
}}

This SNP did not show any association with [[obesity]], [[type-2 diabetes]] or any other related traits in a study of 3,210 Chinese subjects. Furthermore, the minor allele frequency was much lower in Chinese populations compared to populations of European descent.{{PMID|17959933}}

However, a more recent study of 4,189 Chinese Han subjects combined with a meta-analysis of published studies concluded that [[rs8050136]](A) was associated with both increased risk for [[type-2 diabetes]] and [[obesity]].{{PMID|20057365}}

{{PMID|19053021}} rs8050136 associated with increased food intake, but not of impaired energy expenditure.

{{GWAS Summary
|SNP=rs8050136
|PubMedID=17463249
|Condition=Type 2 diabetes
|Gene=FTO
|Risk Allele=A
|pValue=1.00E-012
|OR=1.17
|95CI=1.12-1.22
|OA=1
}}
{{PMID Auto
|PMID=19303973
|Title=RARRES2, encoding the novel adipokine chemerin, is a genetic determinant of disproportionate regional body fat distribution: a comparative magnetic resonance imaging study.
}}
{{PMID Auto
|PMID=19056611
|Title=Adiposity-related heterogeneity in patterns of type 2 diabetes susceptibility observed in genome-wide association data
|OA=1
}}

{{PMID Auto GWAS
|PMID=19079260
|Trait=Body mass index
|Title=Genome-wide association yields new sequence variants at seven loci that associate with measures of obesity
|RiskAllele=A
|Pval=1E-47
|OR=8.04
|ORtxt=[6.96-9.12] % SD
}}
{{PMID Auto GWAS
|PMID=18372903
|Trait=Type 2 diabetes
|Title=Meta-analysis of genome-wide association data and large-scale replication identifies additional susceptibility loci for type 2 diabetes
|RiskAllele=A
|Pval=0.0000069999999999999999
|OR=1.15
|ORtxt=[1.09-1.22]
|OA=1
}}
{{PMID Auto
|PMID=19322589
|Title=Analysis of FTO gene variants with measures of obesity and glucose homeostasis in the IRAS Family Study
|OA=1
}}

{{PMID Auto
|PMID=19543202
|Title=FTO Genotype Is Associated With Exercise Training-induced Changes in Body Composition
|OA=1
}}
{{PMID Auto GWAS
|PMID=17463248
|Trait=Type 2 diabetes
|Title=A genome-wide association study of type 2 diabetes in Finns detects multiple susceptibility variants
|RiskAllele=A
|Pval=1E-12
|OR=1.17
|ORtxt=[1.12-1.22]
|OA=1
}}
{{PMID Auto
|PMID=19584900
|Title=Association of FTO variants with BMI and fat mass in the self-contained population of Sorbs in Germany
|OA=1
}}

{{omim
|desc=FAT MASS- AND OBESITY-ASSOCIATED GENE; FTO
|id=610966
|rsnum=8050136
}}
{{PMID Auto
|PMID=19798072
|Title=FTO Genotype and the Weight Loss Benefits of Moderate Intensity Exercise
|OA=1
}}

{{PharmGKB
|RSID=rs8050136
|Name_s=
|Gene_s=FTO
|Feature=
|Evidence=PubMed ID:19079260; Web Resource:http://www.genome.gov/gwastudies/
|Annotation=GWAS results: Genome-wide association yields new sequence variants at seven loci that associate with measures of obesity. (Initial Sample Size: 80,969 individuals; Replication Sample Size: 11,036 individuals); (Region: 16q12.2; Reported Gene(s): FTO; Risk Allele: rs8050136-A); (p-value= 5E-36).This variant is associated with Weight.
|Drugs=
|Drug Classes=
|Diseases=
|Curation Level=Non-Curated
|PharmGKB Accession ID=PA164740169
}}

{{PMID Auto
|PMID=20061430
|Title=Obesity Susceptibility Genetic Variants Identified from Recent Genome-Wide Association Studies: Implications in a Chinese Population
}}

{{PMID Auto
|PMID=19833889
|Title=Genetic heterogeneity in latent autoimmune diabetes is linked to various degrees of autoimmune activity: results from the Nord-Tr&#xF8;ndelag Health Study
|OA=1
}}

{{PMID Auto
|PMID=20337217
|Title=FTO polymorphisms are associated with obesity but not with diabetes in East Asian populations: a meta-analysis
}}
{{PMID Auto
|PMID=20647405
|Title=No Association between FTO or HHEX and Endometrial Cancer Risk
|OA=1
}}

{{PharmGKB
|RSID=rs8050136
|Name_s=
|Gene_s=FTO
|Feature=
|Evidence=PubMed ID:17463249
|Annotation=rs8050136 is associated with susceptibility to Type 2 Diabetes. This association was identified in a UK case-control study and was replicated in another UK case-control cohort.
|Drugs=
|Drug Classes=
|Diseases=Diabetes Mellitus, Type 2
|Curation Level=Curated
|PharmGKB Accession ID=PA162191333
}}

{{PharmGKB
|RSID=rs8050136
|Name_s=
|Gene_s=FTO
|Feature=
|Evidence=PubMed ID:17463248
|Annotation=In a large Finnish case-control GWAS, rs8050136 was found to be associated with susceptibility to Type 2 Diabetes.
|Drugs=
|Drug Classes=
|Diseases=Diabetes Mellitus, Type 2
|Curation Level=Curated
|PharmGKB Accession ID=PA162191358
}}

{{PharmGKB
|RSID=rs8050136
|Name_s=
|Gene_s=FTO
|Feature=
|Evidence=PubMed ID:17463249; Web Resource:http://www.genome.gov/gwastudies/
|Annotation=GWAS Results: Replication of genome-wide association signals in UK samples reveals risk loci for type 2 diabetes (Initial Sample Size: 1,924 cases, 2,938 controls; Replication Sample Size: 3,757 cases, 5,346 controls; Risk Allele: rs8050136-A).
|Drugs=
|Drug Classes=
|Diseases=Diabetes Mellitus; Diabetes Mellitus, Type 2
|Curation Level=Non-Curated
|PharmGKB Accession ID=PA162356618
}}

{{PharmGKB
|RSID=rs8050136
|Name_s=
|Gene_s=FTO
|Feature=
|Evidence=PubMed ID:19079260; Web Resource:http://www.genome.gov/gwastudies/
|Annotation=GWAS results: Genome-wide association yields new sequence variants at seven loci that associate with measures of obesity. (Initial Sample Size: 80,969 individuals; Replication Sample Size: 11,036 individuals); (Region: 16q12.2; Reported Gene(s): FTO; Risk Allele: rs8050136-A); (p-value= 1E-47).This variant is associated with Body mass index.
|Drugs=
|Drug Classes=
|Diseases=
|Curation Level=Non-Curated
|PharmGKB Accession ID=PA164740147
}}

{{PharmGKB
|RSID=rs8050136
|Name_s=
|Gene_s=FTO
|Feature=
|Evidence=PubMed ID:19056611; Web Resource:http://www.genome.gov/gwastudies/
|Annotation=GWAS results: Adiposity-related heterogeneity in patterns of type 2 diabetes susceptibility observed in genome wide association data. (Initial Sample Size: 1,924 cases, 2,938 controls; Replication Sample Size: 3,757 cases, 5,346 controls); (Region: 16q12.2; Reported Gene(s): FTO; Risk Allele: rs8050136-?); (p-value= 0.00000000000000002).This variant is associated with Type 2 diabetes.
|Drugs=
|Drug Classes=
|Diseases=Diabetes Mellitus; Diabetes Mellitus, Type 2
|Curation Level=Non-Curated
|PharmGKB Accession ID=PA164740293
}}
{{PMID Auto
|PMID=21037323
|Title=Cut-like homeobox 1 (CUX1) regulates expression of the fat mass and obesity-associated (FTO) and retinitis pigmentosa gtpase regulator interacting protein-1 like (RPGRIPIL) genes, and co-ordinates leptin receptor signaling
|OA=1
}}
{{PMID Auto
|PMID=21124985
|Title=Integrated Genetic and Epigenetic Analysis Identifies Haplotype-Specific Methylation in the FTO Type 2 Diabetes and Obesity Susceptibility Locus
|OA=1
}}

{{PMID Auto
|PMID=21266646
|Title=Lifestyle Interaction With Fat Mass and Obesity-Associated (FTO) Genotype and Risk of Obesity in Apparently Healthy U.S. Women
|OA=1
}}

{{PMID Auto GWAS
|PMID=21037115
|Trait=None
|Title=Genome-Wide Association Analysis of Body Mass in Chronic Obstructive Pulmonary Disease
|RiskAllele=A
|Pval=4E-8
|OR=None
|ORtxt=None
|OA=1
}}

{{PMID Auto GWAS
|PMID=21706003
|Trait=None
|Title=Genetic variation near IRS1 associates with reduced adiposity and an impaired metabolic profile.
|RiskAllele=C
|Pval=3E-26
|OR=0.0600
|ORtxt=[NR] % decrease
|OA=1
}}

{{PMID Auto
|PMID=21796137
|Title=Association of variations in the FTO, SCG3 and MTMR9 genes with metabolic syndrome in a Japanese population
}}

{{PMID Auto
|PMID=21868005
|Title=Variations in the fat mass and obesity-associated (FTO) gene are related to glucose levels and higher lipid accumulation product in postmenopausal women from southern Brazil
}}

{{PMID Auto
|PMID=22051089
|Title=Associations of Obesity Genes with Obesity-related Outcomes in Multiethnic Children
|OA=1
}}

{{PMID Auto
|PMID=22355368
|Title=Longitudinal Replication Studies of GWAS Risk SNPs Influencing Body Mass Index over the Course of Childhood and Adulthood
|OA=1
}}

{{PMID Auto
|PMID=17786212
|Title=Heterogeneity in meta-analyses of genome-wide association investigations.
|OA=1
}}

{{PMID Auto
|PMID=17928989
|Title=Variations in the HHEX gene are associated with increased risk of type 2 diabetes in the Japanese population.
}}

{{PMID Auto
|PMID=18162508
|Title=Association of CDKAL1, IGF2BP2, CDKN2A/B, HHEX, SLC30A8, and KCNJ11 with susceptibility to type 2 diabetes in a Japanese population.
}}

{{PMID Auto
|PMID=18224312
|Title=Pharmacogenetics: data, concepts and tools to improve drug discovery and drug treatment.
|OA=1
}}

{{PMID Auto
|PMID=18251005
|Title=Inverse relationship between obesity and FTO gene expression in visceral adipose tissue in humans.
}}

{{PMID Auto
|PMID=18256137
|Title=Regulation of Fto/Ftm gene expression in mice and humans.
|OA=1
}}

{{PMID Auto
|PMID=18335027
|Title=Association analysis of the FTO gene with obesity in children of Caucasian and African ancestry reveals a common tagging SNP.
|OA=1
}}

{{PMID Auto
|PMID=18379722
|Title=Variations in the FTO gene are associated with severe obesity in the Japanese.
|OA=1
}}

{{PMID Auto
|PMID=18423522
|Title=Estimating odds ratios in genome scans: an approximate conditional likelihood approach.
|OA=1
}}

{{PMID Auto
|PMID=18426861
|Title=Association analysis of type 2 diabetes Loci in type 1 diabetes.
|OA=1
}}

{{PMID Auto
|PMID=18443202
|Title=Association analysis in african americans of European-derived type 2 diabetes single nucleotide polymorphisms from whole-genome association studies.
|OA=1
}}

{{PMID Auto
|PMID=18445669
|Title=Lack of association of fatness-related FTO gene variants with energy expenditure or physical activity.
}}

{{PMID Auto
|PMID=18469204
|Title=Implication of genetic variants near TCF7L2, SLC30A8, HHEX, CDKAL1, CDKN2A/B, IGF2BP2, and FTO in type 2 diabetes and obesity in 6,719 Asians.
|OA=1
}}

{{PMID Auto
|PMID=18487448
|Title=Common variation in the fat mass and obesity-associated (FTO) gene confers risk of obesity and modulates BMI in the Chinese population.
|OA=1
}}

{{PMID Auto
|PMID=18535549
|Title=Impact of variation in the FTO gene on whole body fat distribution, ectopic fat, and weight loss.
}}

{{PMID Auto
|PMID=18591388
|Title=Assessing the combined impact of 18 common genetic variants of modest effect sizes on type 2 diabetes risk.
|OA=1
}}

{{PMID Auto
|PMID=18599522
|Title=FTO variants are associated with obesity in the Chinese and Malay populations in Singapore.
|OA=1
}}

{{PMID Auto
|PMID=18689899
|Title=Exchangeable models of complex inherited diseases.
|OA=1
}}

{{PMID Auto
|PMID=18694974
|Title=Predicting type 2 diabetes based on polymorphisms from genome-wide association studies: a population-based study.
|OA=1
}}

{{PMID Auto
|PMID=18782870
|Title=Clinical review: the genetics of type 2 diabetes: a realistic appraisal in 2008.
|OA=1
}}

{{PMID Auto
|PMID=18787525
|Title=FTO polymorphisms are associated with obesity but not diabetes risk in postmenopausal women.
|OA=1
}}

{{PMID Auto
|PMID=18852197
|Title=Metabolic and cardiovascular traits: an abundance of recently identified common genetic variants.
|OA=1
}}

{{PMID Auto
|PMID=18991055
|Title=Association between polymorphisms in SLC30A8, HHEX, CDKN2A/B, IGF2BP2, FTO, WFS1, CDKAL1, KCNQ1 and type 2 diabetes in the Korean population.
}}

{{PMID Auto
|PMID=19002430
|Title=Type 2 diabetes-associated genetic variants discovered in the recent genome-wide association studies are related to gestational diabetes mellitus in the Korean population.
}}

{{PMID Auto
|PMID=19008344
|Title=Association analysis of variation in/near FTO, CDKAL1, SLC30A8, HHEX, EXT2, IGF2BP2, LOC387761, and CDKN2B with type 2 diabetes and related quantitative traits in Pima Indians.
|OA=1
}}

{{PMID Auto
|PMID=19074959
|Title=ATOM: a powerful gene-based association test by combining optimally weighted markers.
|OA=1
}}

{{PMID Auto
|PMID=19096518
|Title=Novel association of HK1 with glycated hemoglobin in a non-diabetic population: a genome-wide evaluation of 14,618 participants in the Women's Genome Health Study.
|OA=1
}}

{{PMID Auto
|PMID=19161620
|Title=An open access database of genome-wide association results.
|OA=1
}}

{{PMID Auto
|PMID=19207020
|Title=Meta-analysis in genome-wide association studies.
|OA=1
}}

{{PMID Auto
|PMID=19323962
|Title=Genome-wide association studies in type 2 diabetes.
|OA=1
}}

{{PMID Auto
|PMID=19341491
|Title=Genome-based prediction of common diseases: methodological considerations for future research.
|OA=1
}}

{{PMID Auto
|PMID=19401414
|Title=Confirmation of multiple risk Loci and genetic impacts by a genome-wide association study of type 2 diabetes in the Japanese population.
|OA=1
}}

{{PMID Auto
|PMID=19460916
|Title=Genetic architecture of type 2 diabetes: recent progress and clinical implications.
|OA=1
}}

{{PMID Auto
|PMID=19474294
|Title=Potential etiologic and functional implications of genome-wide association loci for human diseases and traits.
|OA=1
}}

{{PMID Auto
|PMID=19478790
|Title=The role of obesity-associated loci identified in genome-wide association studies in the determination of pediatric BMI.
|OA=1
}}

{{PMID Auto
|PMID=19553259
|Title=Common body mass index-associated variants confer risk of extreme obesity.
|OA=1
}}

{{PMID Auto
|PMID=19602701
|Title=Underlying genetic models of inheritance in established type 2 diabetes associations.
|OA=1
}}

{{PMID Auto
|PMID=19741467
|Title=Association of common type 2 diabetes risk gene variants and posttransplantation diabetes mellitus in renal allograft recipients in Korea.
}}

{{PMID Auto
|PMID=19862325
|Title=PPARG, KCNJ11, CDKAL1, CDKN2A-CDKN2B, IDE-KIF11-HHEX, IGF2BP2 and SLC30A8 are associated with type 2 diabetes in a Chinese population.
|OA=1
}}

{{PMID Auto
|PMID=19931040
|Title=Simultaneous genotype calling and haplotype phasing improves genotype accuracy and reduces false-positive associations for genome-wide association studies.
|OA=1
}}

{{PMID Auto
|PMID=20009087
|Title=Genetic variation at the FTO locus influences RBL2 gene expression.
|OA=1
}}

{{PMID Auto
|PMID=20017965
|Title=Identifying association under a previous linkage peak on chromosome 16 for body mass index using cross-sectional and longitudinal data of the Framingham Heart Study.
|OA=1
}}

{{PMID Auto
|PMID=20017978
|Title=Influence of control selection in genome-wide association studies: the example of diabetes in the Framingham Heart Study.
|OA=1
}}

{{PMID Auto
|PMID=20018066
|Title=Epistatic interactions of CDKN2B-TCF7L2 for risk of type 2 diabetes and of CDKN2B-JAZF1 for triglyceride/high-density lipoprotein ratio longitudinal change: evidence from the Framingham Heart Study.
|OA=1
}}

{{PMID Auto
|PMID=20049090
|Title=Association between type 2 diabetes loci and measures of fatness.
|OA=1
}}

{{PMID Auto
|PMID=20080751
|Title=Long-range gene regulation links genomic type 2 diabetes and obesity risk regions to HHEX, SOX4, and IRX3.
|OA=1
}}

{{PMID Auto
|PMID=20126254
|Title=Rare variants create synthetic genome-wide associations.
|OA=1
}}

{{PMID Auto
|PMID=20127379
|Title=From monogenic to polygenic obesity: recent advances.
|OA=1
}}

{{PMID Auto
|PMID=20144327
|Title=A genomics study of type 2 diabetes mellitus in U.S. Air Force personnel.
|OA=1
}}

{{PMID Auto
|PMID=20161779
|Title=Investigation of type 2 diabetes risk alleles support CDKN2A/B, CDKAL1, and TCF7L2 as susceptibility genes in a Han Chinese cohort.
|OA=1
}}

{{PMID Auto
|PMID=20377915
|Title=FTO variant rs9939609 is associated with body mass index and waist circumference, but not with energy intake or physical activity in European- and African-American youth.
|OA=1
}}

{{PMID Auto
|PMID=20381893
|Title=The genetics of obesity: FTO leads the way.
|OA=1
}}

{{PMID Auto
|PMID=20421936
|Title=Two new Loci for body-weight regulation identified in a joint analysis of genome-wide association studies for early-onset extreme obesity in French and german study groups.
|OA=1
}}

{{PMID Auto
|PMID=20442772
|Title=Common SNPs in FTO gene are associated with obesity related anthropometric traits in an island population from the eastern Adriatic coast of Croatia.
|OA=1
}}

{{PMID Auto
|PMID=20502638
|Title=Risk of type 2 diabetes and obesity is differentially associated with variation in FTO in whites and African-Americans in the ARIC study.
|OA=1
}}

{{PMID Auto
|PMID=20509872
|Title=Implication of genetic variants near SLC30A8, HHEX, CDKAL1, CDKN2A/B, IGF2BP2, FTO, TCF2, KCNQ1, and WFS1 in type 2 diabetes in a Chinese population.
|OA=1
}}

{{PMID Auto
|PMID=20532014
|Title=The epidemiology of diabetes in Korea: from the economics to genetics.
|OA=1
}}

{{PMID Auto
|PMID=20694148
|Title=A genome-wide association study of the metabolic syndrome in Indian Asian men.
|OA=1
}}

{{PMID Auto
|PMID=20712903
|Title=Obesity and diabetes genes are associated with being born small for gestational age: results from the Auckland Birthweight Collaborative study.
|OA=1
}}

{{PMID Auto
|PMID=21102551
|Title=Analysis of FTO gene variants with obesity and glucose homeostasis measures in the multiethnic Insulin Resistance Atherosclerosis Study cohort.
}}

{{PMID Auto
|PMID=21147891
|Title=Genetic variants associated with persistent central obesity and the metabolic syndrome in a 12-year longitudinal study.
}}

{{PMID Auto
|PMID=21175269
|Title=Genetic variations in the FTO gene are associated with type 2 diabetes and obesity in south Indians (CURES-79).
}}

{{PMID Auto
|PMID=21278902
|Title=Genetic risk profiling for prediction of type 2 diabetes.
|OA=1
}}

{{PMID Auto
|PMID=21283728
|Title=Genetic variants of diabetes risk and incident cardiovascular events in chronic coronary artery disease.
|OA=1
}}

{{PMID Auto
|PMID=21283731
|Title=FTO and MC4R gene variants are associated with obesity in polycystic ovary syndrome.
|OA=1
}}

{{PMID Auto
|PMID=21317302
|Title=FTO polymorphisms are associated with adult body mass index (BMI) and colorectal adenomas in African-Americans.
|OA=1
}}

{{PMID Auto
|PMID=21445555
|Title=Association study of type 2 diabetes genetic susceptibility variants and risk of pancreatic cancer: an analysis of PanScan-I data.
}}

{{PMID Auto
|PMID=22189543
|Title=Genetic variants in FTO associated with metabolic syndrome: a meta- and gene-based analysis.
|OA=1
}}

{{PMID Auto
|PMID=22377712
|Title=Association between type 2 diabetes genetic susceptibility loci and visceral and subcutaneous fat area as determined by computed tomography.
}}

{{GET Evidence
|impact=pathogenic
|qualified_impact=Insufficiently evaluated pathogenic
|inheritance=unknown
|quality_scores=Array
|dbsnp_id=rs8050136
|overall_frequency_n=55
|overall_frequency_d=128
|overall_frequency=0.429688
|n_genomes=34
|n_genomes_annotated=0
|n_haplomes=45
|n_articles=2
|n_articles_annotated=1
|in_gwas=Y
|in_pharmgkb=Y
|autoscore=2
|webscore=N
}}

{{PMID Auto
|PMID=23091647
|Title=Common Variants of FTO Are Associated with Childhood Obesity in a Cross-Sectional Study of 3,126 Urban Indian Children
|OA=1
}}

{{PMID Auto
|PMID=23284729
|Title=Aerobic Fitness Does Not Modify the Effect of FTO Variation on Body Composition Traits
|OA=1
}}

{{PMID Auto
|PMID=23512716
|Title=Association between obesity-related gene FTO and ADHD
}}

{{PMID Auto GWAS
  |PMID=23209189
  |Trait=Type 2 diabetes
  |Title=Genome-wide association study for type 2 diabetes in indians identifies a new susceptibility locus at 2q21.
  |RiskAllele=A
  |Pval=6E-6
  |OR=1.16
  |ORtxt=[1.09-1.24]
  |OA=1
}}

{{PMID Auto
|PMID=22901973
|Title=Fat mass and obesity-associated gene polymorphisms do not affect metabolic response to hormone therapy in healthy postmenopausal women
}}

{{PMID Auto
|PMID=23820787
|Title=Association of the FTO Obesity Risk Variant rs8050136 With Percentage of Energy Intake From Fat in Multiple Racial/Ethnic Populations: The PAGE Study
}}

{{PMID Auto
|PMID=23990951
|Title=Association of genetic variants with isolated fasting hyperglycaemia and isolated postprandial hyperglycaemia in a han chinese population
|OA=1
}}

{{PMID Auto
|PMID=24348519
|Title=EMR-linked GWAS study: investigation of variation landscape of loci for body mass index in children
|OA=1
}}

{{PMID Auto
|PMID=22847851
|Title=Insulin resistant phenotype of polycystic ovary syndrome does not seem to be caused by variation in FTO.
}}

{{PMID Auto
|PMID=22956599
|Title=Evaluation of the genetic overlap between osteoarthritis with body mass index and height using genome-wide association scan data.
|OA=1
}}

{{PMID Auto
|PMID=23298195
|Title=Association study of genetic variants of 17 diabetes-related genes/loci and cardiovascular risk and diabetic nephropathy in the Chinese She population.
}}

{{PMID Auto
|PMID=23300277
|Title=The influence of obesity-related single nucleotide polymorphisms on BMI across the life course: the PAGE study.
|OA=1
}}

{{PMID Auto
|PMID=23334806
|Title=Systematic identification of interaction effects between genome- and environment-wide associations in type 2 diabetes mellitus.
|OA=1
}}

{{PMID Auto
|PMID=23460509
|Title=Replication of genetic effects of MC4R polymorphisms on body mass index in a Korean population.
}}

{{PMID Auto
|PMID=24911064
|Title=Association of FTO Polymorphisms with Obesity and Metabolic Parameters in Han Chinese Adolescents
}}

{{PMID Auto
|PMID=25177340
|Title=Phenome-wide association studies demonstrating pleiotropy of genetic variants within FTO with and without adjustment for body mass index
}}
{{on chip | 23andMe v1}}
{{on chip | 23andMe v2}}
{{on chip | 23andMe v3}}
{{on chip | 23andMe v4}}
{{on chip | Affy GenomeWide 6}}
{{on chip | HumanOmni1Quad}}
{{on chip | Illumina Human 1M}}