{{Rsnum
|rsid=8052394
|Gene=MT1A
|Chromosome=16
|position=56639916
|Orientation=plus
|ReferenceAllele=A
|MissenseAllele=G
|GMAF=0.1598
|Assembly=GRCh38
|GenomeBuild=38.1
|dbSNPBuild=141
|geno1=(A;A)
|geno2=(A;G)
|geno3=(G;G)
|Gene_s=MT1A
}}{{PMID|18349110}} [[type-2 diabetes]] 851 Chinese people of Han descent (397 diabetes and 454 controls).

[[rs8052394]]G was significantly associated with the incidence of type 2 diabetes

{{PMID Auto
|PMID=18194558
|Title=A hierarchical and modular approach to the discovery of robust associations in genome-wide association studies from pooled DNA samples.
|OA=1
}}

{{PMID Auto
|PMID=21128001
|Title=Metallothionein-1 genotypes in the risk of oral squamous cell carcinoma.
}}

{{PMID Auto
|PMID=22233731
|Title=An investigation of modifying effects of metallothionein single-nucleotide polymorphisms on the association between mercury exposure and biomarker levels.
|OA=1
}}

{{GET Evidence
|gene=MT1A
|aa_change=Lys51Arg
|aa_change_short=K51R
|impact=not reviewed
|qualified_impact=Insufficiently evaluated not reviewed
|inheritance=unknown
|quality_scores=Array
|dbsnp_id=rs8052394
|overall_frequency_n=1549
|overall_frequency_d=10758
|overall_frequency=0.143986
|n_genomes=16
|n_genomes_annotated=0
|n_haplomes=19
|n_articles=0
|n_articles_annotated=0
|nblosum100=-3
|autoscore=0
|webscore=N
}}

{{PMID Auto
|PMID=23429061
|Title=Metallothionein 1A polymorphisms may influence urine uric acid and N-acetyl-beta-D-glucosaminidase (NAG) excretion in chronic lead-exposed workers
}}

{{PMID Auto
|PMID=22805858
|Title=Effects of metallothionein-1 genetic polymorphism and cigarette smoking on the development of hepatocellular carcinoma.
}}

{{on chip | 23andMe v3}}
{{on chip | 23andMe v4}}
{{on chip | HumanOmni1Quad}}