{{Rsnum
|rsid=806368
|Gene=CNR1
|Chromosome=6
|position=88140381
|Orientation=plus
|GMAF=0.275
|Assembly=GRCh38
|GenomeBuild=38.1
|dbSNPBuild=141
|Summary=substance dependence (SD) SNP
|geno1=(C;C)
|geno2=(C;T)
|geno3=(T;T)
|Gene_s=CNR1
}}{{ population diversity
| geno1=(C;C)
| geno2=(C;T)
| geno3=(T;T)
| CEU | 4.4 | 40.7 | 54.9
| HCB | 27.7 | 50.4 | 21.9
| JPT | 28.3 | 44.2 | 27.4
| YRI | 0.7 | 12.9 | 86.4
| ASW | 0.0 | 12.3 | 87.7
| CHB | 27.7 | 50.4 | 21.9
| CHD | 29.0 | 45.8 | 25.2
| GIH | 5.0 | 42.0 | 53.0
| LWK | 0.9 | 12.8 | 86.2
| MEX | 10.3 | 46.6 | 43.1
| MKK | 0.6 | 13.5 | 85.9
| TSI | 3.9 | 33.3 | 62.7
| HapMapRevision=28
}}{{PMID|17509535}} risk of the development of substance dependence significantly increased with the number of "G" alleles at [[rs6454674]] and SNP8 ([[rs806368]]);T/T genotypes had significant interaction effects (p = .0003 for comorbid drug dependence (DD) and alcohol dependence (AD), .0002 for DD, and .007 for AD). SNP3 and SNP8 together exerted stronger genetic effects on SD (substance dependence) than either did individually. The peak delta values among all the markers were seen for SNP3 and SNP8 ([[rs806368]])

{{PMID Auto
|PMID=19052543
|Title=Interaction between two independent CNR1 variants increases risk for cocaine dependence in European Americans: a replication study in family-based sample and population-based sample.
|OA=1
}}

{{PMID|18213623|OA=1
}} rs806368(C) together with [[rs1049353]](A) or [[rs1049353]](G) make up a haplotype associated with [[PTSD]], with the C-A haplotype somewhat associated (p=0.04) with higher risk of [[PTSD]] and the C-G haplotype associated (p=0.01) with a lower risk of [[PTSD]]. 

{{PMID Auto
|PMID=22085192
|Title=Cannabinoid Receptor 1 Gene is Associated with Alcohol Dependence. 
}}

Alcoholic patients with TGT haplotype (corresponding to rs6454674-rs1049353-rs806368 polymorphisms in this order) were less prone to have AD (p = 0.017).
TGC haplotype were more likely to develop AD.

{{PMID Auto
|PMID=18179391
|Title=Association between single nucleotide polymorphisms in the cannabinoid receptor gene (CNR1) and impulsivity in southwest California Indians.
}}

Impulsivity was significantly associated with the 6-repeat allele of the triplet repeat polymorphism (AATn/A6; p < .0001), as well as four SNPs in or near the CNR1 receptor gene: rs1535255 (p = .001), rs2023239 (p = .004), rs1049353 (p < .001) and rs806368 (p < .0006). These studies provide data to suggest that the CNR1 receptor gene may be significantly associated with impulsivity in SWC Indians. 

{{PMID Auto
|PMID=18606954
|Title=Cannabinoid receptor 1 gene association with nicotine dependence.
|OA=1
}}

the associations were female specific. Haplotype 1-1-2 of markers rs2023239-rs12720071-rs806368(C) was associated with nicotine dependence and FTND score in the 2 samples (P < .001 and P = .009, respectively).

{{PMID Auto
|PMID=18776593
|Title=Cannabinoid type-1 receptor gene polymorphisms are associated with central obesity in a Southern Brazilian population.
|OA=1
}}

{{PMID Auto
|PMID=19016476
|Title=Evidence for association between polymorphisms in the cannabinoid receptor 1 (CNR1) gene and cannabis dependence.
|OA=1
}}

{{PMID Auto
|PMID=19018721
|Title=Genetic variation in cannabinoid receptor 1 (CNR1) is associated with derangements in lipid homeostasis, independent of body mass index.
|OA=1
}}

{{PMID Auto
|PMID=19335651
|Title=Candidate genes for cannabis use disorders: findings, challenges and directions.
|OA=1
}}

{{PMID Auto
|PMID=19886064
|Title=The implication of CNR1 gene's polymorphisms in the modulation of endocannabinoid system effects.
}}

{{PMID Auto
|PMID=20415562
|Title=Role of genetic variation in the cannabinoid type 1 receptor gene (CNR1) in the pathophysiology of human obesity.
}}

{{PMID Auto
|PMID=20838400
|Title=Are endocannabinoid type 1 receptor gene (CNR1) polymorphisms associated with obesity and metabolic syndrome in postmenopausal Polish women?
}}

{{PMID Auto
|PMID=21129839
|Title=A common variation in the cannabinoid 1 receptor (CNR1) gene is associated with pre-eclampsia in the Central European population.
}}

{{PMID Auto
|PMID=21695734
|Title=Cannabinoid type 1 receptor gene polymorphisms are not associated with olanzapine-induced weight gain.
}}

{{PMID Auto
|PMID=21790903
|Title=Further evidence for association of polymorphisms in the CNR1 gene with cocaine addiction: confirmation in an independent sample and meta-analysis.
|OA=1
}}

{{PMID Auto
|PMID=24407958
|Title=Risky alcohol consumption in young people is associated with the fatty acid amide hydrolase gene polymorphism C385A and affective rating of drug pictures
}}

{{PMID Auto
|PMID=23407780
|Title=Screening genetic variability at the CNR1 gene in both major depression etiology and clinical response to citalopram treatment.
}}

{{PMID Auto
|PMID=25093427
|Title=Selected CNR1 polymorphisms and hyperandrogenemia as well as fat mass and fat distribution in women with polycystic ovary syndrome
}}

{{PMID Auto
|PMID=25136364
|Title=Cannabinoid receptor 1 gene polymorphisms and nonalcoholic Fatty liver disease in women with polycystic ovary syndrome and in healthy controls
}}
{{on chip | 23andMe v1}}
{{on chip | 23andMe v2}}
{{on chip | 23andMe v3}}
{{on chip | 23andMe v4}}
{{on chip | FTDNA2}}
{{on chip | FTDNA}}
{{on chip | HumanOmni1Quad}}
{{on chip | Illumina Human 1M}}