{{Rsnum
|rsid=806380
|Gene=CNR1
|Chromosome=6
|position=88154934
|Orientation=plus
|GMAF=0.2185
|Assembly=GRCh38
|GenomeBuild=38.1
|dbSNPBuild=141
|geno1=(A;A)
|geno2=(A;G)
|geno3=(G;G)
|Gene_s=CNR1
}}{{ population diversity
| geno1=(A;A)
| geno2=(A;G)
| geno3=(G;G)
| CEU | 46.8 | 43.5 | 9.7
| HCB | 60.0 | 37.5 | 2.5
| JPT | 68.9 | 31.1 | 0.0
| YRI | 88.7 | 11.3 | 0.0
| ASW | 0.0 | 0.0 | 0.0
| CHB | 60.0 | 37.5 | 2.5
| CHD | 0.0 | 0.0 | 0.0
| GIH | 0.0 | 0.0 | 0.0
| LWK | 0.0 | 0.0 | 0.0
| MEX | 0.0 | 0.0 | 0.0
| MKK | 0.0 | 0.0 | 0.0
| TSI | 0.0 | 0.0 | 0.0
| HapMapRevision=28
}}
This snp, located in intron 2 of the central cannabinoid receptor [[CNR1]] gene, has been linked to [[cannabis dependence]]. {{PMID|16917946|OA=1
}}

The (G) allele is reported to have a protective effect, and is a defining part of a haplotype that is associated with lower odds of developing cannabis dependence. The (A) allele is more common in all populations studied.

{{PMID Auto
|PMID=19443135
|Title=The association between cannabinoid receptor 1 gene (CNR1) and cannabis dependence symptoms in adolescents and young adults
|OA=1
}}

{{PMID Auto
|PMID=18606954
|Title=Cannabinoid receptor 1 gene association with nicotine dependence.
|OA=1
}}

{{PMID Auto
|PMID=19016476
|Title=Evidence for association between polymorphisms in the cannabinoid receptor 1 (CNR1) gene and cannabis dependence.
|OA=1
}}

{{PMID Auto
|PMID=19052543
|Title=Interaction between two independent CNR1 variants increases risk for cocaine dependence in European Americans: a replication study in family-based sample and population-based sample.
|OA=1
}}

{{PMID Auto
|PMID=19335651
|Title=Candidate genes for cannabis use disorders: findings, challenges and directions.
|OA=1
}}

{{PMID|21714860|OA=1
}} Variation in the human cannabinoid receptor CNR1 gene modulates gaze duration for happy faces. (G;G) is also associated with the longest gaze duration for happy faces.

{{on chip | 23andMe v1}}
{{on chip | 23andMe v2}}
{{on chip | 23andMe v3}}
{{on chip | 23andMe v4}}
{{on chip | FTDNA2}}
{{on chip | HumanOmni1Quad}}