{{Rsnum
|rsid=8067378
|Chromosome=17
|position=39895095
|Orientation=plus
|GMAF=0.4578
|Assembly=GRCh38
|GenomeBuild=38.1
|dbSNPBuild=141
|Summary=childhood asthma
|geno1=(A;A)
|geno2=(A;G)
|geno3=(G;G)
}}{{ population diversity
| geno1=(A;A)
| geno2=(A;G)
| geno3=(G;G)
| CEU | 21.2 | 55.8 | 23.0
| HCB | 44.5 | 45.3 | 10.2
| JPT | 51.3 | 40.7 | 8.0
| YRI | 24.5 | 48.3 | 27.2
| ASW | 26.3 | 38.6 | 35.1
| CHB | 44.5 | 45.3 | 10.2
| CHD | 53.2 | 40.4 | 6.4
| GIH | 39.6 | 45.5 | 14.9
| LWK | 18.2 | 46.4 | 35.5
| MEX | 34.5 | 48.3 | 17.2
| MKK | 22.4 | 44.2 | 33.3
| TSI | 22.8 | 55.4 | 21.8
| HapMapRevision=28
}}[[rs8067378]] is the strongest associating SNP from a region of chromosome 17q21 found in a large (ultimately over 7,000 patients in 3 populations) genome-wide association study of childhood [[asthma]].{{PMID|17611496}}

Since the associated SNPs were also strongly associated (p < 10<sup>-22</sup>) in cis with transcript levels of from the [[ORMDL3]] gene, the authors concluded that genetic variants regulating ORMDL3 expression are determinants of susceptibility to childhood [[asthma]].{{PMID|17611496}}

{{PMID Auto GWAS
|PMID=20228799
|Trait=Ulcerative colitis
|Title=Genome-wide association identifies multiple ulcerative colitis susceptibility loci
|RiskAllele=A
|Pval=1E-7
|OR=1.12
|ORtxt=[NR]
|OA=1
}}

{{omim
|id=611403
|rsnum=8067378
}}

{{PMID Auto
|PMID=22370936
|Title=Genetic variants on 17q21 are associated with asthma  in a Han Chinese population
}}

{{PMID|19264973|OA=1
}} Assessing the reproducibility of asthma candidate gene associations, using genome-wide data.

{{PMID|19426955|OA=1
}} Genome-wide association analysis identifies PDE4D as an asthma-susceptibility gene.

{{PMID|19714205|OA=1
}} Genome-wide association study implicates chromosome 9q21.31 as a susceptibility locus for asthma in mexican children.

{{PMID|19732864|OA=1
}} Allele-specific chromatin remodeling in the ZPBP2/GSDMB/ORMDL3 locus associated with the risk of asthma and autoimmune disease.

{{PMID|20698975|OA=1
}} Asthma-susceptibility variants identified using probands in case-control and family-based analyses.

{{PMID Auto GWAS
  |PMID=23817570
  |Trait=Cervical cancer
  |Title=A genome-wide association study identifies two new cervical cancer susceptibility loci at 4q12 and 17q12.
  |RiskAllele=G
  |Pval=9E-10
  |OR=1.19
  |ORtxt=[1.13-1.26]
  }}

{{on chip | 23andMe v1}}
{{on chip | 23andMe v2}}
{{on chip | 23andMe v3}}
{{on chip | 23andMe v4}}
{{on chip | FTDNA2}}
{{on chip | FTDNA}}
{{on chip | HumanOmni1Quad}}
{{on chip | Illumina Human 1M}}