{{Rsnum
|rsid=8069176
|Chromosome=17
|position=39900944
|Orientation=plus
|GMAF=0.3852
|Assembly=GRCh38
|GenomeBuild=38.1
|dbSNPBuild=141
|geno1=(A;A)
|geno2=(A;G)
|geno3=(G;G)
}}{{ population diversity
| geno1=(A;A)
| geno2=(A;G)
| geno3=(G;G)
| CEU | 21.2 | 51.3 | 27.4
| HCB | 10.2 | 45.3 | 44.5
| JPT | 8.0 | 40.7 | 51.3
| YRI | 10.9 | 46.9 | 42.2
| ASW | 22.8 | 40.4 | 36.8
| CHB | 10.2 | 45.3 | 44.5
| CHD | 6.4 | 39.4 | 54.1
| GIH | 11.9 | 46.5 | 41.6
| LWK | 10.0 | 43.6 | 46.4
| MEX | 17.2 | 43.1 | 39.7
| MKK | 3.2 | 31.4 | 65.4
| TSI | 19.6 | 52.0 | 28.4
| HapMapRevision=28
}}[[rs8069176]] is one of several SNPs from a region on chromosome 17q21 that has been linked to risk for [[asthma]].

A total of 651 French patients with [[asthma]], from among 1,621 subjects in 388 families, were analyzed for SNPs in the (17q21) region. An association was found between this SNP and early-onset [[asthma]] (but not with later onset asthma) which was significant after correction at p < 0.001. Upon further study, this association was seen primarily only in children exposed to tobacco smoke. The odds ratio was 2.9, based on the most likely assumption that this risk is associated only with the recessive homozygous state (and not the heterozygous state, which is still possible). {{PMID|18923164}}

{{PharmGKB
|RSID=rs8069176
|Name_s=
|Gene_s=-
|Feature=
|Evidence=PubMed ID:18923164
|Annotation=This variant in the 17q21 region was strongly associated (P<0.001) with early-onset asthma. The study shows that the risk increases further by early-life exposure to environmental tobacco smoke.
|Drugs=
|Drug Classes=
|Diseases=Asthma
|Curation Level=Curated
|PharmGKB Accession ID=PA162356826
}}

{{omim
|id=611403
|rsnum=8069176
}}

{{PMID Auto
|PMID=22370936
|Title=Genetic variants on 17q21 are associated with asthma  in a Han Chinese population
}}

{{GET Evidence
|impact=pharmacogenetic
|qualified_impact=Insufficiently evaluated pharmacogenetic
|inheritance=unknown
|quality_scores=Array
|dbsnp_id=rs8069176
|overall_frequency_n=48
|overall_frequency_d=128
|overall_frequency=0.375
|n_genomes=30
|n_genomes_annotated=0
|n_haplomes=39
|n_articles=1
|n_articles_annotated=0
|in_pharmgkb=Y
|autoscore=1
|webscore=N
}}

{{PMID Auto GWAS
  |PMID=24315451
  |Trait=Fractional exhaled nitric oxide (childhood)
  |Title=Fraction of exhaled nitric oxide values in childhood are associated with 17q11.2-q12 and 17q12-q21 variants.
  |RiskAllele=A
  |Pval=2E-8
  |OR=.07
  |ORtxt=[0.042-0.09] unit decrease
  }}
{{on chip | 23andMe v3}}
{{on chip | 23andMe v4}}
{{on chip | Illumina Human 1M}}