{{Rsnum
|rsid=8089
|Gene=THBS2
|Chromosome=6
|position=169217631
|Orientation=minus
|GMAF=0.1823
|Assembly=GRCh38
|GenomeBuild=38.1
|dbSNPBuild=141
|geno1=(G;G)
|geno2=(G;T)
|geno3=(T;T)
|Gene_s=THBS2
}}{{ population diversity
| geno1=(G;G)
| geno2=(G;T)
| geno3=(T;T)
| CEU | 5.3 | 38.9 | 55.8
| HCB | 0.0 | 17.0 | 83.0
| JPT | 1.8 | 19.5 | 78.8
| YRI | 6.1 | 32.0 | 61.9
| ASW | 7.0 | 28.1 | 64.9
| CHB | 0.0 | 17.0 | 83.0
| CHD | 1.8 | 20.2 | 78.0
| GIH | 3.0 | 17.0 | 80.0
| LWK | 0.9 | 29.1 | 70.0
| MEX | 1.8 | 28.1 | 70.2
| MKK | 5.8 | 34.8 | 59.4
| TSI | 7.8 | 39.2 | 52.9
| HapMapRevision=28
}}[[rs8089]], a SNP in the thrombospondin-2 [[THBS2]] gene, was studied as part of a large study (>5,000 Caucasian patients) for risk of myocardial infarction and thus [[heart disease]]. Although statistically not overwhelming, a risk was seen (odds ratio 1.19, CI: 1.02-1.39, compared to (T;T) homozygotes) for carriers of the less common [[rs8089]](G) allele. In a meta-analysis combining several studies, no statistically significant association for heart attacks was seen for [[rs8089]], nor for that matter, 2 other SNPs, [[rs2228262]] (also known as Asn700Ser) or [[rs1866389]] (also known as Ala387Pro), in thrombospondins -1 and -4, respectively.{{PMID|18178577}}

{{PMID|18455130|OA=1
}} A functional polymorphism in THBS2 that affects alternative splicing and MMP binding is associated with lumbar-disc herniation.

{{PMID|21762961}} An association study of thrombospondin 1 and 2 SNPs with coronary artery disease and myocardial infarction among South Indians.

{{on chip | 23andMe v1}}
{{on chip | 23andMe v2}}
{{on chip | 23andMe v3}}
{{on chip | 23andMe v4}}
{{on chip | Affy GenomeWide 6}}
{{on chip | FTDNA2}}
{{on chip | HumanOmni1Quad}}
{{on chip | Illumina Human 1M}}