{{Rsnum
|rsid=8103142
|Gene=IL28B
|Chromosome=19
|position=39244466
|Orientation=plus
|GMAF=0.2952
|Assembly=GRCh38
|GenomeBuild=38.1
|dbSNPBuild=141
|geno1=(C;C)
|geno2=(C;T)
|geno3=(T;T)
|Gene_s=IFNL3
}}{{PMID Auto
|PMID=19749757
|Title=Genome-wide association of IL28B with response to pegylated interferon-alpha and ribavirin therapy for chronic hepatitis C
}}

{{omim
|desc=INTERLEUKIN 28B; IL28B
|id=607402
|rsnum=8103142
}}

{{PharmGKB
|RSID=rs8103142
|Name_s=
|Gene_s=IL28B
|Feature=
|Evidence=PubMed ID:19749757
|Annotation=Phenotype: This variant is associated with null virological response (NVR) in Janapese patients with hepatitis C virus infection treated with PEG-INF-alpha plus ribavirin. Study size: 304. Study population/ethnicity: Japanese. Significance metric(s): P=1.4 x 10(-29) (NVR). Type of association: GN; CO
|Drugs=interferon alfa-2a, recombinant; ribavirin
|Drug Classes=
|Diseases=Hepatitis C; Hepatitis C, Chronic
|Curation Level=Curated
|PharmGKB Accession ID=PA165260382
}}

{{PharmGKB
|RSID=rs8103142
|Name_s=
|Gene_s=IL28B
|Feature=
|Evidence=PubMed ID:19684573
|Annotation=Phenotype: Sequencing of the IL28B gene in 96 individuals found this SNP to be highly associated with rs12979860 (r-squared > 0.85), which, in a GWAS done in patients of European ancestry, African-Americans and Hispanics was significantly associated with rate of SVR (sustained virological response) to treatment of chronic Hepatitis C genotype I infection with peginterferon-alpha-2a or -2b combined with ribavirin.
|Drugs=interferon alfa-2a, recombinant; ribavirin
|Drug Classes=
|Diseases=Hepatitis; Hepatitis C; Liver Cirrhosis
|Curation Level=Curated
|PharmGKB Accession ID=PA165363369
}}
{{PMID Auto
|PMID=21070502
|Title=Interleukin-28B polymorphisms are associated with hepatitis C virus clearance and viral load in a HIV-1-infected cohort
}}

{{omim
|id=609532
|rsnum=8103142
}}

{{PMID Auto
|PMID=22234924
|Title=Combined effects of different IL28B gene variants on the outcome of dual combination therapy in chronic HCV type 1 infection
}}

{{PMID Auto
|PMID=22295096
|Title=Genetic Variations in IL28B and Allergic Disease in Children
|OA=1
}}

{{PMID Auto
|PMID=22328925
|Title=Deciphering the Interleukin 28B Variants That Better Predict Response to Pegylated Interferon-? and Ribavirin Therapy in HCV/HIV-1 Coinfected Patients
|OA=1
}}

{{PMID Auto
|PMID=22649509
|Title=IL28B Genetic Variation Is Associated with Spontaneous Clearance of Hepatitis C Virus, Treatment Response, Serum IL-28B Levels in Chinese Population
|OA=1
}}

{{PMID|20887330}} High sensitivity assay using serum sample for IL28B genotyping to predict treatment response in chronic hepatitis C patients.

{{PMID|21360716|OA=1
}} Estimating the net contribution of interleukin-28B variation to spontaneous hepatitis C virus clearance.

{{PMID|21389156|OA=1
}} The rs8099917 polymorphism, when determined by a suitable genotyping method, is a better predictor for response to pegylated alpha interferon/ribavirin therapy in Japanese patients than other single nucleotide polymorphisms associated with interleukin-28B.

{{GET Evidence
|gene=IL28B
|aa_change=Lys70Arg
|aa_change_short=K70R
|impact=pharmacogenetic
|qualified_impact=Insufficiently evaluated pharmacogenetic
|inheritance=unknown
|quality_scores=Array
|dbsnp_id=rs8103142
|overall_frequency_n=34
|overall_frequency_d=86
|overall_frequency=0.395349
|n_genomes=22
|n_genomes_annotated=0
|n_haplomes=32
|n_articles=1
|n_articles_annotated=1
|in_pharmgkb=Y
|nblosum100=-3
|autoscore=1
|webscore=N
}}

{{PMID Auto
|PMID=22719902
|Title=Analysis of IL28B variants in an Egyptian population defines the 20 kilobases minimal region involved in spontaneous clearance of hepatitis C virus
|OA=1
}}

{{PMID Auto
|PMID=23109451
|Title=IL28B polymorphisms predict the response to chronic hepatitis C virus infection treatment in a Mexican population
}}

{{PMID Auto
|PMID=23866096
|Title=The predictive value of IL28B rs12979860, rs11881222 and rs8099917 polymorphisms and IP-10 in the therapeutic response of Egyptian genotype 4 patients
}}

{{PMID Auto
|PMID=25032184
|Title=No association between the IL28B SNP and response to peginterferon plus ribavirin combination treatment in Korean chronic hepatitis C patients
}}
{{on chip | 23andMe v3}}
{{on chip | HumanOmni1Quad}}
{{on chip | Illumina Human 1M}}