{{Rsnum
|rsid=8133052
|Gene=CBR3
|Chromosome=21
|position=36135203
|Orientation=plus
|GMAF=0.4045
|Gene_s=CBR3,CBR3-AS1
|Assembly=GRCh38
|GenomeBuild=38.1
|dbSNPBuild=141
|geno1=(A;A)
|geno2=(A;G)
|geno3=(G;G)
}}{{ population diversity
| geno1=(A;A)
| geno2=(A;G)
| geno3=(G;G)
| CEU | 27.3 | 52.7 | 20.0
| HCB | 21.6 | 50.0 | 28.4
| JPT | 18.3 | 56.9 | 24.8
| YRI | 4.8 | 42.8 | 52.4
| ASW | 10.5 | 50.9 | 38.6
| CHB | 21.6 | 50.0 | 28.4
| CHD | 20.8 | 49.1 | 30.2
| GIH | 9.2 | 45.9 | 44.9
| LWK | 6.6 | 38.7 | 54.7
| MEX | 17.2 | 55.2 | 27.6
| MKK | 12.0 | 44.0 | 44.0
| TSI | 22.8 | 49.5 | 27.7
| HapMapRevision=28
}}{{PharmGKB
|RSID=rs8133052
|Name_s=CBR3 11G>A; CBR3:Cys4Tyr
|Gene_s=CBR3, RPS9P1
|Feature=
|Evidence=PubMed ID:18551042
|Annotation=Risk or phenotype-associated allele: A. Phenotype: CBR3 11G>A variant was associated with lower doxorubicinol AUC, lower CBR3 expression in breast tumor tissue, greater tumor reduction, and greater percentage reduction of leukocyte and platelet counts at nadir. Study size: 101 Study population/ethnicity: Asian; patients with Breast Neoplasms; Chinese; Malay; Indian Significance metric(s): p = 0.009 (AUC); p = 0.001 (expression); p = 0.015 (tumor reduction); p = 0.03 (leukocyte and platelet counts). Type of association: PK; TOX
|Drugs=doxorubicin
|Drug Classes=ANTHRACYCLINES AND RELATED SUBSTANCES
|Diseases=Breast Neoplasms; Drug Toxicity
|Curation Level=Curated
|PharmGKB Accession ID=PA165291531
}}

{{GET Evidence
|gene=CBR3
|aa_change=Cys4Tyr
|aa_change_short=C4Y
|impact=pharmacogenetic
|qualified_impact=Insufficiently evaluated pharmacogenetic
|inheritance=unknown
|quality_scores=Array
|dbsnp_id=rs8133052
|overall_frequency_n=3643
|overall_frequency_d=9894
|overall_frequency=0.368203
|n_genomes=26
|n_genomes_annotated=0
|n_haplomes=31
|n_articles=1
|n_articles_annotated=1
|in_pharmgkb=Y
|pph2_score=0.002
|nblosum100=6
|autoscore=1
|webscore=N
}}

{{on chip | 23andMe v1}}
{{on chip | 23andMe v2}}
{{on chip | 23andMe v3}}
{{on chip | 23andMe v4}}
{{on chip | FTDNA2}}
{{on chip | HumanOmni1Quad}}
{{on chip | Illumina Human 1M}}