{{Rsnum
|rsid=8175347
|Chromosome=2
|Orientation=plus
|Gene=UGT1A10
|position=233760235
|Assembly=GRCh38
|GenomeBuild=38.1
|dbSNPBuild=141
|Gene_s=UGT1A1,UGT1A3,UGT1A4,UGT1A5,UGT1A6,UGT1A7,UGT1A8,UGT1A9,UGT1A10
}}The [[rs8175347]] SNP consists of variation of a short (TA)(n) repeat sequence covering the TATA box of the [[UGT1A1]] UDP-glucuronosyltransferase1A1 gene. This SNP is associated with [[hyperbilirubinaemia]] (Gilbert's syndrome) and adverse drug reactions, and is used for dosage advice for [[irinotecan]]. The low-activity (risk) alleles are [[rs8175347]](TA)7 and (TA)8. 

{{PharmGKB
|RSID=rs8175347
|Name_s=UGT1A1*28, 7-TA insertion in promoter, short tandem repeat (microsatellite) (TA)7
|Gene_s=UGT1A10, UGT1A3, UGT1A4, UGT1A5, UGT1A6, UGT1A7, UGT1A8, UGT1A9, UGT1A1
|Feature=Intron, Intron, Intron, Intron, Intron, Intron, Intron, Intron, NA
|Evidence=PubMed ID:17577039
|Annotation=Risk or phenotype-associated allele: (TA)7 repeat insertion in the UGT1A1 promoter. Phenotype: Patients with the UGT1A1*28 7/7 genotype had a statistically greater baseline total bilirubin than patients with homozygous (6-TA repeat) 6/6 or heterozygous 6/7 genotype (p = 0.005). UGT1A1*28 genotype was not associated with grade 3 and 4 neutropenia (p > 0.2) or diarrhea (p > 0.1). However, patients with the *28 7/7 genotype tended to have higher SN-38 area under the plasma time-concentration curve (AUC) values and lower SN-38-glucuronide to SN-38 AUC ratios. Study size: 74. Study population/ethnicity: Pediatric patients from five institutional clinical trials with solid tumors receiving low-dose, protracted irinotecan (15 to 75 mg/m2 daily for 5 days for 2 consecutive weeks). Significance metric(s): p = 0.005 - 0.2. Type of association: GN; PK; PD.
|Drugs=irinotecan; SN-38
|Drug Classes=
|Diseases=Drug Toxicity; Neoplasms
|Curation Level=Curated
|PharmGKB Accession ID=PA165111309
}}

{{PharmGKB
|RSID=rs8175347
|Name_s=UGT1A1*28, 7-TA insertion in promoter, short tandem repeat (microsatellite) (TA)7
|Gene_s=UGT1A10, UGT1A3, UGT1A4, UGT1A5, UGT1A6, UGT1A7, UGT1A8, UGT1A9, UGT1A1
|Feature=Intron, Intron, Intron, Intron, Intron, Intron, Intron, Intron, NA
|Evidence=PubMed ID:15122075
|Annotation=Risk or phenotype-associated allele: TA repeat insertion in UGT1A1 promoter, TA(7). Phenotype: There was no significant association between systemic exposure of tipifarnib (AUC levels) and UGT1A1*28 (promoter TA(7) repeat) genotype. Study size: 28 (16 male). Study population/ethnicity: Caucasian cancer patients, aged 34-75. Significance metric(s): Not significant, p = 0.79. Type of association: GN; PK
|Drugs=Tipifarnib
|Drug Classes=
|Diseases=
|Curation Level=Curated
|PharmGKB Accession ID=PA165111314
}}
{{PMID Auto
|PMID=21309756
|Title=Prevalence of clinically relevant UGT1A alleles and haplotypes in African populations
}}
{{PMID Auto
|PMID=22050734
|Title=UGT1A1*28 variant allele is a predictor of severe hyperbilirubinemia in HIV-infected patients on HAART in southern Brazil
}}{{PMID|18349273}} UGT1A1 genetic polymorphisms, endogenous estrogen exposure, soy food intake, and endometrial cancer risk.

{{PMID|19414484|OA=1
}} Genome-wide association meta-analysis for total serum bilirubin levels.

{{PMID|19482841|OA=1
}} Serum bilirubin levels on ICU admission are associated with ARDS development and mortality in sepsis.

{{PMID|20389299|OA=1
}} Pazopanib-induced hyperbilirubinemia is associated with Gilbert's syndrome UGT1A1 polymorphism.

{{PMID|22580719}} UGT1A1, SLCO1B1, and SLCO1B3 polymorphisms versus neonatal hyperbilirubinemia: is there an association?{{PMID Auto
|PMID=22633539
|Title=Selected polymorphisms in sex hormone-related genes, circulating sex hormones and risk of endometrial cancer.
|OA=1
}}
{{PMID Auto
|PMID=25086287
|Title=Genetic variation underlying common hereditary hyperbilirubinaemia (Gilbert's syndrome) and respiratory health in the 1946 British birth cohort
}}
{{PMID Auto
|PMID=24865931
|Title=Combined effects of the UGT1A1 and OATP2 gene polymorphisms as major risk factor for unconjugated hyperbilirubinemia in Indian neonates
}}