{{Rsnum
|rsid=8176719
|Gene=ABO
|Chromosome=9
|position=133257521
|Orientation=plus
|ReferenceAllele=G
|GMAF=0.3489
|Assembly=GRCh38
|GenomeBuild=38.1
|dbSNPBuild=141
|geno1=(-;-)
|geno2=(-;G)
|geno3=(G;G)
}}[[ABO blood group]]

[[rs8176719]] represents a site in the [[ABO]] gene, and is a key SNP in determining blood group type O status. {{PMID|2333095}}

An allele that encodes either a blood group type A or type B will have a (G) at this SNP site, i.e. such an allele will be [[rs8176719]](G). If a one-base deletion has occured at this site, removing this nucleotide all together, the corresponding allele is considered to be [[rs8176719]](-) and encodes the most common blood group type O allele.  However, an individual will typically only be blood group type O if they are carry two copies of (are homozygous) for this deletion, in other words, if their genotype is [[rs8176719]](-;-). If they carry one copy, they could be blood type A, or blood type B (but are unlikely to be type O). A person who is [[rs8176719]](G;G) is likely to be of blood type A, B, or AB, but due to the existence of (rare) nonfunctional O alleles brought about by (nondeletional) mutations at other positions than [[rs8176719]], they could at least theoretically still be phenotyped as type O.

The determination of blood group types A, B, and AB through SNP analysis is reflected in the appropriate [[genosets]].

{{omim
|id=110300
|rsnum=8176719
}}

{{PMID Auto
|PMID=18464913
|Title=A genome-wide association study identifies protein quantitative trait loci (pQTLs).
|OA=1
}}

{{PMID Auto
|PMID=19169360
|Title=Histo-blood group gene polymorphisms as potential genetic modifiers of infection and cystic fibrosis lung disease severity.
|OA=1
}}

{{PMID Auto
|PMID=21257350
|Title=DNA-based methods in the immunohematology reference laboratory.
|OA=1
}}

{{PMID Auto
|PMID=21306478
|Title=ABO blood group alleles and the risk of pancreatic cancer in a Japanese population.
}}

{{PMID Auto
|PMID=21680535
|Title=ABO genotype and the risk of gastric cancer, atrophic gastritis, and Helicobacter pylori infection.
}}

{{PMID Auto GWAS
|PMID=22672568
|Trait=None
|Title=A genome-wide association study of venous thromboembolism identifies risk variants in chromosomes 1q24.2 and 9q.
|RiskAllele=G
|Pval=6E-12
|OR=1.4700
|ORtxt=None
|OA=1
}}

{{PMID Auto GWAS
  |PMID=22895189
  |Trait=Malaria
  |Title=Genome-wide association study indicates two novel resistance loci for severe malaria.
  |RiskAllele=G
  |Pval=4E-21
  |OR=1.48
  |ORtxt=[NR]
  }}

{{PMID Auto
|PMID=23734777
|Title=Lack of strong effect modification by NFE2L2/CYP3A5/ABO of the risk of venous thrombosis associated with oral hormone therapy.
}}

{{PMID Auto
|PMID=25210051
|Title=Genetic Variations Associated with Recurrent Venous Thrombosis
}}
{{on chip | 23andMe v2}}
{{on chip | 23andMe v3}}
{{on chip | 23andMe v4}}