{{Rsnum
|rsid=8176746
|Gene=ABO
|Chromosome=9
|position=133255935
|Orientation=plus
|ReferenceAllele=C
|MissenseAllele=A
|GMAF=0.123
|Assembly=GRCh38
|GenomeBuild=38.1
|dbSNPBuild=141
|geno1=(A;A)
|geno2=(A;C)
|geno3=(C;C)
|Gene_s=ABO
}}{{ population diversity
| geno1=(A;A)
| geno2=(A;C)
| geno3=(C;C)
| CEU | 0.0 | 15.0 | 85.0
| HCB | 6.6 | 27.7 | 65.7
| JPT | 1.8 | 34.5 | 63.7
| YRI | 3.4 | 27.2 | 69.4
| ASW | 5.3 | 14.0 | 80.7
| CHB | 6.6 | 27.7 | 65.7
| CHD | 1.8 | 24.8 | 73.4
| GIH | 7.9 | 34.7 | 57.4
| LWK | 4.6 | 23.9 | 71.6
| MEX | 0.0 | 15.5 | 84.5
| MKK | 1.9 | 21.2 | 76.9
| TSI | 1.0 | 14.9 | 84.2
| HapMapRevision=28
}}

This SNP is a variant in the [[ABO]] gene, and is therefore potentially useful in determining [[ABO blood group]], such as through the use of [[genosets]].

{{interesting}}
23andMe reports this as a G/T while decodeme reports it as a an A/C.

{{PMID Auto GWAS
|PMID=20139978
|Trait=Hematological and biochemical traits
|Title=Genome-wide association study of hematological and biochemical traits in a Japanese population
|RiskAllele=T
|Pval=4E-8
|OR=0.21
|ORtxt=[NR] % variance
}}

{{PharmGKB
|RSID=rs8176746
|Name_s=Marker for B antigen allele; rs8176746 C>A
|Gene_s=ABO
|Feature=
|Evidence=PubMed ID:20066004
|Annotation=Risk or phenotype-associated allele: A Phenotype: Angiotensin converting enzyme activity was increased per copy of the rs8176746 A allele. Carriage of the A allele is associated with the B blood group antigen. Study size: 623 Study population/ethnicity: Academia Sinica Multi-Centered Young-Onset Hypertension (AS-YOH) Genetic Study; Han Chinese individuals with Hypertension. Significance metric(s): p = 9.3 &#215; 10&#8722;5 Type of association: PD
|Drugs=
|Drug Classes=ACE INHIBITORS, PLAIN
|Diseases=Hypertension
|Curation Level=Curated
|PharmGKB Accession ID=PA165111695
}}

{{omim
|id=110300
|rsnum=8176746
}}

{{PMID Auto
|PMID=18464913
|Title=A genome-wide association study identifies protein quantitative trait loci (pQTLs).
|OA=1
}}

{{PMID Auto
|PMID=18604267
|Title=Novel association of ABO histo-blood group antigen with soluble ICAM-1: results of a genome-wide association study of 6,578 women.
|OA=1
}}

{{PMID Auto
|PMID=20459687
|Title=Candidate malaria susceptibility/protective SNPs in hospital and population-based studies: the effect of sub-structuring.
|OA=1
}}

{{PMID Auto
|PMID=21257350
|Title=DNA-based methods in the immunohematology reference laboratory.
|OA=1
}}

{{PMID Auto
|PMID=21306478
|Title=ABO blood group alleles and the risk of pancreatic cancer in a Japanese population.
}}

{{PMID Auto
|PMID=21680535
|Title=ABO genotype and the risk of gastric cancer, atrophic gastritis, and Helicobacter pylori infection.
}}

{{PMID Auto
|PMID=21792085
|Title=ABO blood group and chronic pancreatitis risk in the NAPS2 cohort.
|OA=1
}}

{{PMID Auto
|PMID=21832968
|Title=Pharmacogenetic predictors of angiotensin-converting enzyme inhibitor-induced cough: the role of ACE, ABO, and BDKRB2 genes.
}}

{{PMID Auto
|PMID=22258027
|Title=A common variant of the ABO gene protects against hypertension in a Spanish population.
}}

{{GET Evidence
|gene=ABO
|aa_change=Leu265Met
|aa_change_short=L265M
|impact=not reviewed
|qualified_impact=Insufficiently evaluated not reviewed
|inheritance=unknown
|quality_scores=Array
|dbsnp_id=rs8176746
|overall_frequency_n=995
|overall_frequency_d=9860
|overall_frequency=0.100913
|n_genomes=14
|n_genomes_annotated=0
|n_haplomes=14
|n_articles=0
|n_articles_annotated=0
|nblosum100=-3
|autoscore=0
|webscore=N
}}



{{on chip | 23andMe v1}}
{{on chip | 23andMe v2}}
{{on chip | 23andMe v3}}
{{on chip | 23andMe v4}}
{{on chip | HumanOmni1Quad}}
{{on chip | Illumina Human 1M}}