{{Rsnum
|rsid=8187710
|Gene=ABCC2
|Chromosome=10
|position=101611294
|Orientation=plus
|GMAF=0.06979
|Assembly=GRCh37
|GenomeBuild=37.1
|dbSNPBuild=131
|geno1=(A;A)
|geno2=(A;G)
|geno3=(G;G)
}}
{{ population diversity
| geno1=(A;A)
| geno2=(A;G)
| geno3=(G;G)
| CEU | 0.0 | 10.6 | 89.4
| HCB | 0.0 | 0.0 | 100.0
| JPT | 0.0 | 0.0 | 100.0
| YRI | 1.4 | 23.8 | 74.8
| ASW | 1.8 | 21.1 | 77.2
| CHB | 0.0 | 0.0 | 100.0
| CHD | 0.0 | 0.0 | 0.0
| GIH | 0.0 | 2.0 | 98.0
| LWK | 2.7 | 36.4 | 60.9
| MEX | 0.0 | 8.6 | 91.4
| MKK | 2.6 | 23.7 | 73.7
| TSI | 0.0 | 22.5 | 77.5
| HapMapRevision=28
}}
{{PMID Auto
|PMID=19842932
|Title=Association between ABCC2 polymorphism and lopinavir accumulation in peripheral blood mononuclear cells of HIV-infected patients
}}

{{PharmGKB
|RSID=rs8187710
|Name_s=ABCC2 rs8187710, MRP2 Cys1515Tyr
|Gene_s=ABCC2
|Feature=Exon/NonSyn
|Evidence=PubMed ID:16330681
|Annotation=Risk or phenotype-associated allele: A. Phenotype: This SNP was part of a haplotype associated with acute cardiotoxicity in response to doxorubicin. Study size: 1697. Study population/ethnicity: Participants of the German non-Hodgkin lymphoma study. Significance metric(s): OR = 2.3; 95% CI, 1.0 to 5.4. Type of association: PD; ADR; TOX.
|Drugs=doxorubicin
|Drug Classes=
|Diseases=Arrhythmias, Cardiac; Cardiomyopathies; Drug Toxicity; Lymphoma, Non-Hodgkin
|Curation Level=Curated
|PharmGKB Accession ID=PA165291814
}}

{{PharmGKB
|RSID=rs8187710
|Name_s=
|Gene_s=ABCC2
|Feature=Exon/NonSyn
|Evidence=PubMed ID:19842932
|Annotation=Risk or phenotype-associated allele: A. Phenotype: This SNP in ABCC2 was associated with a higher accumulation of lopinavir in peripheral blood mononuclear cells of HIV-treated patients. Study size: 53. Type of association: GN.
|Drugs=lopinavir
|Drug Classes=
|Diseases=HIV Infections
|Curation Level=Curated
|PharmGKB Accession ID=PA165109573
}}

{{PMID Auto
|PMID=17997497
|Title=Association of the multidrug-resistance-associated protein gene (ABCC2) variants with intrahepatic cholestasis of pregnancy.
}}

{{PMID Auto
|PMID=18176959
|Title=Increased susceptibility for intrahepatic cholestasis of pregnancy and contraceptive-induced cholestasis in carriers of the 1331T>C polymorphism in the bile salt export pump.
|OA=1
}}

{{PMID Auto
|PMID=18395921
|Title=Role of ABCC2 common variants in intrahepatic cholestasis of pregnancy.
|OA=1
}}

{{PMID Auto
|PMID=18926681
|Title=Polymorphisms of MRP2 (ABCC2) are associated with susceptibility to nonalcoholic fatty liver disease.
}}

{{PMID Auto
|PMID=22027652
|Title=Functional defect caused by the 4544G>A SNP in ABCC2: potential impact for drug cellular disposition.
}}

{{GET Evidence
|gene=ABCC2
|aa_change=Cys1515Tyr
|aa_change_short=C1515Y
|impact=pharmacogenetic
|qualified_impact=Insufficiently evaluated pharmacogenetic
|inheritance=unknown
|quality_scores=Array
|dbsnp_id=rs8187710
|overall_frequency_n=1033
|overall_frequency_d=10758
|overall_frequency=0.0960216
|n_genomes=16
|n_genomes_annotated=0
|n_haplomes=16
|n_articles=2
|n_articles_annotated=2
|gene_in_genetests=Y
|in_pharmgkb=Y
|genetests_testable=Y
|nblosum100=6
|autoscore=3
|webscore=N
|n_web_uneval=8
}}

{{PMID Auto
|PMID=23069858
|Title=Impact of ABCC2 polymorphisms on high-dose methotrexate pharmacokinetics in patients with lymphoid malignancy.
}}

{{on chip | 23andMe v1}}
{{on chip | 23andMe v2}}
{{on chip | 23andMe v3}}
{{on chip | 23andMe v4}}
{{on chip | FTDNA2}}
{{on chip | FTDNA}}
{{on chip | HumanOmni1Quad}}
{{on chip | Illumina Human 1M}}