{{Rsnum
|rsid=8192284
|Gene=IL6R
|geno1=(A;A)
|geno2=(A;C)
|geno3=(C;C)
|Orientation=plus
|ReferenceAllele=A
|MissenseAllele=C
|Chromosome=1
|position=154454494
|Assembly=GRCh38
|GenomeBuild=38.1
|dbSNPBuild=141
|Status=Merged
|Merged=2228145
|Gene_s=IL6R
}}{{ population diversity
| geno1=(A;A)
| geno2=(A;C)
| geno3=(C;C)
| CEU | 43.4 | 42.5 | 14.2
| HCB | 36.8 | 47.8 | 15.4
| JPT | 42.9 | 42.9 | 14.3
| YRI | 87.1 | 12.2 | 0.7
| ASW | 70.2 | 29.8 | 0.0
| CHB | 36.8 | 47.8 | 15.4
| CHD | 33.9 | 44.0 | 22.0
| GIH | 48.5 | 48.5 | 3.0
| LWK | 86.4 | 13.6 | 0.0
| MEX | 27.6 | 41.4 | 31.0
| MKK | 79.5 | 17.9 | 2.6
| TSI | 36.3 | 50.0 | 13.7
| HapMapRevision=28
}}A study of 219 female [[melanoma]] patients and an equal number of controls concluded that 4 linked SNPs within the [[IL6R]] gene were associated with increased [[melanoma]] risk, but only when heterozygous. The odds ratio associated with the minor allele of this SNP, [[rs8192284]] (also known as Asp358Ala), was 1.68 (CI: 1.04-2.73). The 4 linked SNPs from identified in this study are: [[rs6684439]], [[rs4845618]], [[rs4845622]], and [[rs8192284]].{{PMID|18781131|OA=1
}}

linked to [[diabetes]] by {{PMID|17898129}}

{{PMID|19124510|OA=1
}} [[multiple myeloma]]  
*[[rs1801278]] [C/T versus C/C genotypes; OR, 4.3; 95% confidence interval (CI), 1.5-12.1]
*[[rs6684439]] (T/T versus C/C; OR, 2.9; 95% CI, 1.2-7.0)
*[[rs7529229]] (C/C versus T/T; OR, 2.5; 95% CI, 1.1-6.0)
*[[rs8192284]] (C/C versus A/A; OR, 2.5, 95% CI, 1.1-6.0)

{{GWAS Summary
|SNP=rs8192284
|PubMedID=18439548
|Condition=C-reactive protein
|Gene=IL6R
|Risk Allele=
|pValue=2.00E-008
|OR=0.1
|95CI=NR) mg/dl decreas
|OA=1
}}
{{ neighbor
| rsid = 4129267
| distance = 707
}}
{{PMID Auto
|PMID=19280716
|Title=The IL6-174G/C polymorphism is associated with celiac disease susceptibility in girls.
}}

{{omim
|id=147880
|desc=INTERLEUKIN 6 RECEPTOR; IL6R
|rsnum=8192284
}}
{{PMID Auto
|PMID=19671870
|Title=Prognostic Significance of Interleukin-6 Single Nucleotide Polymorphism Genotypes in Neuroblastoma: rs1800795 (Promoter) and rs8192284 (Receptor)
|OA=1
}}
{{PMID Auto
|PMID=19713205
|Title=A gain of function polymorphism in the interleukin-6 receptor influences RA susceptibility
}}
{{PMID Auto
|PMID=19926672
|Title=Genotype at the sIL-6R A358C polymorphism does not influence response to anti-TNF therapy in patients with rheumatoid arthritis
}}
{{PMID Auto
|PMID=20031590
|Title=The Relation of Genetic and Environmental Factors to Systemic Inflammatory Biomarker Concentrations
|OA=1
}}
{{PMID Auto GWAS
|PMID=20031577
|Trait=Fibrinogen
|Title=Novel Loci, Including Those Related to Crohn Disease, Psoriasis, and Inflammation Identified in a Genome-Wide Association Study of Fibrinogen in 17,686 Women: The Women's Genome Health Study
|RiskAllele=C
|Pval=2E-11
|OR=5.30
|ORtxt=[NR] mg/dl decrease
|OA=1
}}

{{PMID Auto
|PMID=20186139
|Title=Interleukin-6 Receptor Gene Polymorphism Modulates Interleukin-6 Levels and the Metabolic Syndrome: GBCS-CVD
}}

{{PMID Auto
|PMID=20551110
|Title=Influence of IL6R rs8192284 Polymorphism Status in Disease Activity in Rheumatoid Arthritis
}}
{{PMID Auto
|PMID=20197062
|Title=Interleukin-6 receptor gene polymorphisms were associated with sporadic Alzheimer's disease in Chinese Han
}}

{{PMID Auto
|PMID=22421340
|Title=The interleukin-6 receptor as a target for prevention of coronary heart disease: a mendelian randomisation analysis
|OA=1
}}

{{PMID Auto
|PMID=22677780
|Title=Interleukin-6 -634G&gt;C Genetic Polymorphism Is Associated with Prognosis following Surgery for Advanced Thoracic Esophageal Squamous Cell Carcinoma
}}

{{PMID Auto
|PMID=22742541
|Title=No evidence of association between functional polymorphisms located within IL6R and IL6ST genes and systemic sclerosis
}}

{{PMID Auto
|PMID=24059848
|Title=Interleukin-6 polymorphisms and hematologic malignancy: a re-appraisal of evidence from genetic association studies
}}
{{on chip | 23andMe v1}}
{{on chip | 23andMe v2}}
{{on chip | 23andMe v3}}
{{on chip | 23andMe v4}}
{{on chip | HumanOmni1Quad}}
{{on chip | Illumina Human 1M}}