{{Rsnum
|rsid=8192288
|Gene=SOD3
|Chromosome=4
|position=24795056
|Orientation=plus
|GMAF=0.05647
|Assembly=GRCh38
|GenomeBuild=38.1
|dbSNPBuild=141
|geno1=(G;G)
|geno2=(G;T)
|geno3=(T;T)
|Gene_s=SOD3
}}[[rs8192287]] and the nearby [[rs8192288]] are both SNPs in the superoxide dismutase 3 [[SOD3]] gene. This gene encodes a protein that inhibits breakdown of lung matrix components such as collagen.

A large study ultimately genotyping over 45,000 Danish adults concludes that the very rare individuals who carry only minor alleles at both [[rs8192287]] and [[rs8192288]] have reduced (by 7%) lung capacity compared to noncarriers. They are also at higher risk (2.5x or 3.7x, respectively) for being hospitalized in association with, or dying from, [[chronic obstructive pulmonary disease]], also known as COPD.{{PMID|18703790|OA=1
}}
{{ neighbor
| rsid = 8192287
| distance = 110
}}
{{ neighbor
| rsid = 699473
| distance = 125
}}

{{PMID Auto
|PMID=18948423
|Title=Extracellular superoxide dismutase haplotypes are associated with acute lung injury and mortality.
|OA=1
}}

{{PMID Auto
|PMID=19318538
|Title=Superoxide dismutase 3, extracellular (SOD3) variants and lung function.
|OA=1
}}

{{PMID Auto
|PMID=20673035
|Title=Polymorphisms in the superoxide dismutase-3 gene are associated with emphysema in COPD.
|OA=1
}}

{{on chip | 23andMe v3}}
{{on chip | 23andMe v4}}