{{Rsnum
|rsid=821616
|Gene=DISC1
|Chromosome=1
|position=232008852
|Orientation=minus
|ReferenceAllele=A
|MissenseAllele=T
|GMAF=0.2484
|Gene_s=DISC1,MAP1LC3C
|Assembly=GRCh38
|GenomeBuild=38.1
|dbSNPBuild=141
|geno1=(A;A)
|geno2=(A;T)
|geno3=(T;T)
}}{{ population diversity
| geno1=(A;A)
| geno2=(A;T)
| geno3=(T;T)
| CEU | 13.8 | 38.5 | 47.7
| HCB | 2.2 | 24.4 | 73.3
| JPT | 2.3 | 9.1 | 88.6
| YRI | 11.1 | 55.6 | 33.3
| ASW | 0.0 | 0.0 | 0.0
| CHB | 2.2 | 24.4 | 73.3
| CHD | 0.0 | 0.0 | 0.0
| GIH | 0.0 | 0.0 | 0.0
| LWK | 0.0 | 0.0 | 0.0
| MEX | 0.0 | 0.0 | 0.0
| MKK | 0.0 | 0.0 | 0.0
| TSI | 0.0 | 0.0 | 0.0
| HapMapRevision=28
}}Women with two [[rs821616]](T) SNPs seem to experience more rapid cognitive decline as they age compared to men. {{PMID|16054297}}

{{PMID|17673452}} 13 single-nucleotide polymorphisms (SNPs) in 723 members of 179 Finnish [[Bipolar disorder]]  families.
*[[rs821616]] verbal fluency 

{{Venter SNP
|rsid=821616
|allele=T
|frequency=0.308
|uid=1103675362829
|type=heterozygous_SNP
|hugo=DISC1
|ensembl gene=ENSG00000162946
|ensembl transcript=ENST00000366638
|sift=TOLERATED
|disease=A chromosomal aberration involving DISC1 segregates with schizophrenia and related psychiatric disorders in a large Scottish family. Translocation t(1;11)(q42.1;q14.3).
}}

{{PMID Auto
|PMID=19805229
|Title=DISC1 splice variants are upregulated in schizophrenia and associated with risk polymorphisms
|OA=1
}}

{{PMID Auto
|PMID=21878470
|Title=Effect of DISC1 on the P300 Waveform in Psychosis
|OA=1
}}

{{PMID Auto
|PMID=22673686
|Title=Gender-specific association of TSNAX/DISC1 locus for schizophrenia and bipolar affective disorder in South Indian population
}}

{{PMID Auto
|PMID=15386212
|Title=Disrupted in schizophrenia 1 (DISC1): association with schizophrenia, schizoaffective disorder, and bipolar disorder.
|OA=1
}}

{{PMID Auto
|PMID=15939883
|Title=Variation in DISC1 affects hippocampal structure and function and increases risk for schizophrenia.
|OA=1
}}

{{PMID Auto
|PMID=17286247
|Title=Positive association of the Disrupted-in-Schizophrenia-1 gene (DISC1) with schizophrenia in the Chinese Han population.
}}

{{PMID Auto
|PMID=17997036
|Title=Association study of polymorphisms between DISC1 and schizophrenia in a Korean population.
}}

{{PMID Auto
|PMID=18072279
|Title=Combining fMRI and SNP data to investigate connections between brain function and genetics using parallel ICA.
|OA=1
}}

{{PMID Auto
|PMID=19188535
|Title=Association of variants in DISC1 with psychosis-related traits in a large population cohort.
|OA=1
}}

{{PMID Auto
|PMID=19300510
|Title=The DISC1 pathway modulates expression of neurodevelopmental, synaptogenic and sensory perception genes.
|OA=1
}}

{{PMID Auto
|PMID=19414483
|Title=The DISC locus and schizophrenia: evidence from an association study in a central European sample and from a meta-analysis across different European populations.
|OA=1
}}

{{PMID Auto
|PMID=20403199
|Title=High-throughput analysis of candidate imprinted genes and allele-specific gene expression in the human term placenta.
|OA=1
}}

{{PMID Auto
|PMID=20531374
|Title=Association of Disrupted in Schizophrenia 1 (DISC1) missense variants with ultra-resistant schizophrenia.
}}

{{GET Evidence
|gene=DISC1
|aa_change=Ser736Cys
|aa_change_short=S736C
|impact=not reviewed
|qualified_impact=Insufficiently evaluated not reviewed
|inheritance=unknown
|quality_scores=Array
|dbsnp_id=rs821616
|n_genomes=1
|n_genomes_annotated=0
|n_haplomes=1
|n_articles=0
|n_articles_annotated=0
|nblosum100=3
|autoscore=1
|webscore=N
}}

{{PMID Auto
|PMID=23140672
|Title=DISC1 (disrupted-in-schizophrenia 1) is associated with cortical grey matter volumes in the human brain: a voxel-based morphometry (VBM) study
}}

{{PMID Auto
|PMID=23602339
|Title=Human brain imaging studies of DISC1 in schizophrenia, bipolar disorder and depression: a systematic review.
}}

{{on chip | 23andMe v2}}
{{on chip | 23andMe v3}}
{{on chip | 23andMe v4}}
{{on chip | Illumina Human 1M}}