{{Rsnum
|rsid=833061
|Gene=VEGFA
|Chromosome=6
|position=43769749
|Orientation=plus
|GMAF=0.3802
|Assembly=GRCh38
|GenomeBuild=38.1
|dbSNPBuild=141
|geno1=(C;C)
|geno2=(C;T)
|geno3=(T;T)
|Gene_s=VEGFA
}}{{ population diversity
| geno1=(C;C)
| geno2=(C;T)
| geno3=(T;T)
| CEU | 20.4 | 54.0 | 25.7
| HCB | 4.4 | 39.7 | 55.9
| JPT | 12.4 | 42.5 | 45.1
| YRI | 6.1 | 48.3 | 45.6
| ASW | 1.8 | 45.6 | 52.6
| CHB | 4.4 | 39.7 | 55.9
| CHD | 10.1 | 35.8 | 54.1
| GIH | 12.9 | 44.6 | 42.6
| LWK | 8.2 | 51.8 | 40.0
| MEX | 12.1 | 56.9 | 31.0
| MKK | 8.3 | 34.0 | 57.7
| TSI | 32.4 | 45.1 | 22.5
| HapMapRevision=28
}}{{PMID Auto
|PMID=19761764
|Title=Association between vascular endothelial growth factor gene polymorphisms and age-related macular degeneration in a Polish population
}}

{{PMID Auto
|PMID=19594543
|Title=Effect of vascular endothelial growth factor polymorphisms on survival in advanced-stage non-small-cell lung cancer
}}
{{PMID Auto
|PMID=19875757
|Title=Clinical relevance of vascular endothelial growth factor (VEGFA) and VEGF receptor (VEGFR2) gene polymorphism on the treatment outcome following imatinib therapy
}}

{{PharmGKB
|RSID=rs833061
|Name_s=VEGFA:(-460)C>T; VEGF-A -460 C/T
|Gene_s=VEGFA
|Feature=
|Evidence=PubMed ID:20125120
|Annotation=Risk or phenotype-associated allele: CT. Phenotype: Response was observed in 26% of the patients with the -460 CT genotype compared with 57% with CC+TT. Study size: 72. Study population/ethnicity: Patients with metastatic colorectal neoplasms; Denmark. Significance metric(s): p = 0.01. Type of association: PD
|Drugs=capecitabine; oxaliplatin
|Drug Classes=
|Diseases=Colorectal Neoplasms
|Curation Level=Curated
|PharmGKB Accession ID=PA165282109
}}

{{PMID Auto
|PMID=20847577
|Title=Vascular Endothelial Growth Factor Gene Polymorphisms and Risk of Neovascular Age-Related Macular Degeneration in a Chinese Cohort
}}

{{PharmGKB
|RSID=rs833061
|Name_s=VEGFA:T-1498C
|Gene_s=VEGFA
|Feature=
|Evidence=PubMed ID:17891484
|Annotation=The C allele of this SNP was associated with increased breast cancer risk in Caucasian women.
|Drugs=
|Drug Classes=
|Diseases=Breast Neoplasms
|Curation Level=Curated
|PharmGKB Accession ID=PA164891511
}}

{{PharmGKB
|RSID=rs833061
|Name_s=VEGFA:C-460T
|Gene_s=VEGFA
|Feature=
|Evidence=PubMed ID:18223238
|Annotation=This SNP was not associated with risk of non-small cell lung cancer.
|Drugs=
|Drug Classes=
|Diseases=Carcinoma, Non-Small-Cell Lung
|Curation Level=Curated
|PharmGKB Accession ID=PA164891512
}}

{{omim
|id=192240
|rsnum=833061
}}

{{omim
|id=264800
|rsnum=833061
}}

{{PMID Auto
|PMID=22439647
|Title=The outcome and predictive factors of sunitinib therapy in advanced gastrointestinal stromal tumors (GIST) after imatinib failure - one institution study
|OA=1
}}

{{PMID Auto
|PMID=22162628
|Title=Polymorphisms in the vascular endothelial growth factor gene and the risk of diabetic retinopathy in Chinese patients with type 2 diabetes
|OA=1
}}

{{PMID|16613616|OA=1
}} Polymorphisms in the vascular endothelial growth factor gene and breast cancer in the Cancer Prevention Study II cohort.

{{PMID|17319747|OA=1
}} Large-scale evaluation of candidate genes identifies associations between VEGF polymorphisms and bladder cancer risk.

{{PMID|17983459}} Vascular endothelial growth factor (VEGF) gene (VEGFA) polymorphism can predict the prognosis in acute myeloid leukaemia patients.

{{PMID|18281657}} VEGF polymorphisms and survival in early-stage non-small-cell lung cancer.

{{PMID|18378209}} Vascular endothelial growth factor gene polymorphisms in age-related macular degeneration.

{{PMID|18650217}} Polymorphisms in the vascular endothelial growth factor gene and the risk of familial endometriosis.

{{PMID|18780893|OA=1
}} Genetic polymorphisms of VEGF, interactions with cigarette smoking exposure and esophageal adenocarcinoma risk.

{{PMID|18805939|OA=1
}} Functional genetic polymorphisms and female reproductive disorders: part II--endometriosis.

{{PMID|19041064}} Vascular endothelial growth factor gene polymorphisms may predict the risk of acute graft-versus-host disease following allogeneic transplantation: preventive effect of vascular endothelial growth factor gene on acute graft-versus-host disease.

{{PMID|19308252|OA=1
}} Genetic variation in VEGF does not contribute significantly to the risk of congenital cardiovascular malformation.

{{PMID|19566948|OA=1
}} Polymorphisms of TGFB1 and VEGF genes and survival of patients with gastric cancer.

{{PMID|19584152|OA=1
}} Vascular endothelial growth factor polymorphisms and esophageal cancer prognosis.

{{PMID|19755511|OA=1
}} The role of vascular endothelial growth factor SNPs as predictive and prognostic markers for major solid tumors.

{{PMID|19835575|OA=1
}} The VEGF -634G>C promoter polymorphism is associated with risk of gastric cancer.

{{PMID|20389299|OA=1
}} Pazopanib-induced hyperbilirubinemia is associated with Gilbert's syndrome UGT1A1 polymorphism.

{{PMID|21080079}} Gene polymorphism of vascular endothelial growth factor -1154 G>A is associated with hypertensive nephropathy in a Hispanic population.

{{PMID|21347390|OA=1
}} Genetics of VEGF serum variation in human isolated populations of cilento: importance of VEGF polymorphisms.

{{PMID|21362767}} Interaction between smoking and polymorphism in the promoter region of the VEGFA gene is associated with ischemic heart disease and myocardial infarction in rheumatoid arthritis.

{{PMID|21982816}} Contribution of VEGF polymorphisms to variation in VEGF serum levels in a healthy population.

{{PMID|22139971}} Vascular endothelial growth factor (VEGF) gene polymorphisms may influence the efficacy of thalidomide in multiple myeloma.

{{PMID|22307787}} Pooled-analysis of the associations between three polymorphisms in the VEGF gene and age-related macular degeneration.

{{PMID|22320189|OA=1
}} Polymorphisms of the vascular endothelial growth factor gene and severe radiation pneumonitis in non-small cell lung cancer patients treated with definitive radiotherapy.

{{PMID|22429695}} Polymorphism in the vascular endothelial growth factor A (VEGFA) gene is associated with serum VEGF-A level and disease activity in rheumatoid arthritis: differential effect of cigarette smoking.

{{PMID|22521084}} Role of Vascular Endothelial Growth Factor Polymorphisms in the Treatment Success in Patients with Wet Age-related Macular Degeneration.

{{PMID Auto
|PMID=23073296
|Title=VEGF Polymorphisms are not associated with an Increased Risk of Developing Renal Cell Carcinoma in Spanish population
}}

{{GET Evidence
|impact=pharmacogenetic
|qualified_impact=Insufficiently evaluated pharmacogenetic
|inheritance=unknown
|quality_scores=Array
|dbsnp_id=rs833061
|overall_frequency_n=79
|overall_frequency_d=128
|overall_frequency=0.617188
|n_genomes=44
|n_genomes_annotated=0
|n_haplomes=63
|n_articles=3
|n_articles_annotated=2
|in_pharmgkb=Y
|autoscore=1
|webscore=N
}}

{{PMID Auto
|PMID=23404364
|Title=Polymorphisms in the VEGFA promoter are associated with susceptibility to hepatocellular carcinoma by altering promoter activity
}}

{{PMID Auto
|PMID=22776467
|Title=Age at onset of rheumatoid arthritis: association with polymorphisms in the vascular endothelial growth factor A(VEGFA) gene and an intergenic locus between matrix metalloproteinase (MMP) 1 and 3 genes
}}

{{PMID Auto
|PMID=23511629
|Title=VEGF and VEGFR polymorphisms affect clinical outcome in advanced renal cell carcinoma patients receiving first-line sunitinib
|OA=1
}}

{{PMID Auto
|PMID=24039754
|Title=The impact of polymorphic variations in the 5p15, 6p12, 6p21 and 15q25 Loci on the risk and prognosis of portuguese patients with non-small cell lung cancer
|OA=1
}}

{{PMID Auto
|PMID=24353087
|Title=Assessment of the associations between three VEGF polymorphisms and risk of prostate cancer
}}

{{PMID Auto
|PMID=24623964
|Title=Candidate gene association study for diabetic retinopathy in Chinese patients with type 2 diabetes
|OA=1
}}

{{PMID Auto
|PMID=22925497
|Title=The relation of vascular endothelial growth factor (VEGF) gene polymorphisms on VEGF levels and the risk of vasoocclusive crisis in sickle cell disease.
}}

{{PMID Auto
|PMID=23061744
|Title=Association of the vascular endothelial growth factor gene polymorphisms (-460C/T, +405G/C and +936T/C) with endometriosis: a meta-analysis.
}}

{{PMID Auto
|PMID=23064377
|Title=Influence of vascular endothelial growth factor single nucleotide polymorphisms on non-small cell lung cancer tumor angiogenesis.
|OA=1
}}

{{PMID Auto
|PMID=23264084
|Title=Positive association of the vascular endothelial growth factor-A +405 GG genotype and poor survival in stage I-II gastric cancer in the Northern Chinese population.
}}

{{PMID Auto
|PMID=24868559
|Title=The Associations between VEGF Gene Polymorphisms and Diabetic Retinopathy Susceptibility: A Meta-Analysis of 11 Case-Control Studies
}}

{{PMID Auto
|PMID=25148899
|Title=Investigating the association of vascular endothelial growth factor polymorphisms with breast cancer: a Moroccan case-control study
}}
{{on chip | 23andMe v3}}
{{on chip | 23andMe v4}}
{{on chip | Illumina Human 1M}}