{{Rsnum
|rsid=853326
|Gene=TG
|Chromosome=8
|position=132897729
|Orientation=minus
|ReferenceAllele=A
|MissenseAllele=G
|GMAF=0.3641
|Assembly=GRCh38
|GenomeBuild=38.1
|dbSNPBuild=141
|geno1=(C;C)
|geno2=(C;T)
|geno3=(T;T)
|Gene_s=TG
}}{{ population diversity
| geno1=(C;C)
| geno2=(C;T)
| geno3=(T;T)
| CEU | 20.4 | 49.6 | 30.1
| HCB | 61.3 | 30.7 | 8.0
| JPT | 54.0 | 42.5 | 3.5
| YRI | 63.9 | 29.9 | 6.1
| ASW | 59.6 | 31.6 | 8.8
| CHB | 61.3 | 30.7 | 8.0
| CHD | 57.8 | 34.9 | 7.3
| GIH | 54.5 | 37.6 | 7.9
| LWK | 46.4 | 43.6 | 10.0
| MEX | 24.1 | 62.1 | 13.8
| MKK | 59.6 | 32.7 | 7.7
| TSI | 32.4 | 50.0 | 17.6
| HapMapRevision=28
}}{{Venter SNP
|rsid=853326
|allele=G
|frequency=0.458
|uid=1103652448063
|type=heterozygous_SNP
|hugo=TG
|ensembl gene=ENSG00000042832
|ensembl transcript=ENST00000220616
|sift=TOLERATED
|disease=Defects in TG are a cause of some forms of goiter (MIM:188450). Goiter is an enlargement of the thyroid gland. This is sometimes linked to hypothyroidism.
}}

{{omim
|id=188450
|rsnum=853326
|variant=0010
}}

{{ClinVar
|rsid=853326
|Reversed=1
|FwdREF=T
|FwdALT=C
|REF=A
|ALT=G
|RSPOS=133909974
|CHROM=8
|GMAF=0.364
|dbSNPBuildID=86
|SSR=0
|SAO=1
|VP=0x05016000000015051f110100
|GENEINFO=TG:7038
|GENE_NAME=TG
|GENE_ID=7038
|WGT=0
|VC=SNV
|CLNALLE=1
|CLNHGVS=NC_000008.10:g.133909974A>G
|CLNSRC=OMIM Allelic Variant
|CLNORIGIN=1
|CLNSRCID=188450.0010
|CLNSIG=255
|CLNCUI=C1842444
|CLNDBN=Autoimmune thyroid disease 3
|Disease=Autoimmune thyroid disease 3
|CLNACC=RCV000013535.1
|Tags=RV;PM;SLO;VLD;G5;HD;GNO;KGPhase1;KGPilot123;KGPROD;OTHERKG;PH3;LSD;OM
|CAF=0.3641; 0.6359
|CLNDSDB=MedGen:OMIM
|CLNDSDBID=C1842444:608175
|COMMON=1
}}

{{GET Evidence
|gene=TG
|aa_change=Met1028Val
|aa_change_short=M1028V
|impact=not reviewed
|qualified_impact=Insufficiently evaluated not reviewed
|inheritance=unknown
|quality_scores=Array
|dbsnp_id=rs853326
|overall_frequency_n=6355
|overall_frequency_d=10758
|overall_frequency=0.590723
|n_genomes=42
|n_genomes_annotated=0
|n_haplomes=65
|n_articles=0
|n_articles_annotated=0
|gene_in_genetests=Y
|pph2_score=0.003
|genetests_testable=Y
|nblosum100=0
|autoscore=1
|webscore=N
}}

{{on chip | 23andMe v1}}
{{on chip | 23andMe v2}}
{{on chip | 23andMe v3}}
{{on chip | 23andMe v4}}
{{on chip | FTDNA2}}
{{on chip | HumanOmni1Quad}}
{{on chip | Illumina Human 1M}}