{{Rsnum
|rsid=855791
|Gene=TMPRSS6
|Chromosome=22
|position=37066896
|Orientation=minus
|GMAF=0.3981
|Assembly=GRCh38
|GenomeBuild=38.1
|dbSNPBuild=141
|geno1=(C;C)
|geno2=(C;T)
|geno3=(T;T)
|Gene_s=TMPRSS6
}}{{ population diversity
| geno1=(C;C)
| geno2=(C;T)
| geno3=(T;T)
| CEU | 35.4 | 46.9 | 17.7
| HCB | 17.5 | 54.7 | 27.7
| JPT | 13.3 | 51.3 | 35.4
| YRI | 79.6 | 19.0 | 1.4
| ASW | 64.9 | 31.6 | 3.5
| CHB | 17.5 | 54.7 | 27.7
| CHD | 18.3 | 46.8 | 34.9
| GIH | 20.8 | 41.6 | 37.6
| LWK | 82.7 | 16.4 | 0.9
| MEX | 24.1 | 39.7 | 36.2
| MKK | 83.3 | 16.7 | 0.0
| TSI | 31.4 | 46.1 | 22.5
| HapMapRevision=28
}}[[rs855791]], also known as V736A, is a SNP in the transmembrane protease, serine 6 [[TMPRSS6]] gene.

2 studies totaling over 17,000 individuals have linked this SNP to various blood parameters, including iron status, erythrocyte volume, and hemoglobin levels.[PMID 19820699, PMID 19820698]

[http://blog.23andme.com/2009/10/12/snpwatch-genetic-variations-influencing-hemoglobin-levels-identified/ 23andMe blog]  each [[rs855791]](T) and each [[rs198846]](G) led to an approximately 0.1 gram per deciliter (g/dL) decrease in hemoglobin levels. [[rs1799945]](C) is a proxy for [[rs198846]](G).

{{PMID Auto GWAS
|PMID=19862010
|Trait=Hemoglobin
|Title=Multiple loci influence erythrocyte phenotypes in the CHARGE Consortium
|RiskAllele=A
|Pval=3E-25
|OR=0.09
|ORtxt=[0.07-0.11] g/dl decrease
|OA=1
}}

{{PMID Auto
|PMID=20858683
|Title=Common variants at ten genomic loci influence hemoglobin A1C levels via glycemic and non-glycemic pathways
|OA=1
}}
{{PMID Auto GWAS
|PMID=20927387
|Trait=None
|Title=A genome-wide association study of red blood cell traits using the electronic medical record
|RiskAllele=A
|Pval=1E-12
|OR=0.29
|ORtxt=[0.21-0.37] unit decrease
|OA=1
}}

{{PMID Auto GWAS
|PMID=21149283
|Trait=None
|Title=Novel Association to the Proprotein Convertase PCSK7 Gene Locus Revealed by Analysing Soluble Transferrin Receptor (sTfR) Levels
|RiskAllele=A
|Pval=2E-15
|OR=0.0190
|ORtxt=[0.015-0.023] unit increase
|OA=1
}}
{{omim
|id=613284
|rsnum=855791
}}

{{PMID Auto GWAS
|PMID=21785125
|Trait=None
|Title=Association of HFE and TMPRSS6 genetic variants with iron and erythrocyte parameters is only in part dependent on serum hepcidin concentrations.
|RiskAllele=
|Pval=5E-7
|OR=0.1870
|ORtxt=[0.12-0.26] ng/ml decrease
}}

{{PMID Auto
|PMID=21873547
|Title=TMPRSS6 rs855791 modulates hepcidin transcription in vitro and serum hepcidin levels in normal individuals.
}}

{{PMID Auto
|PMID=22815867
|Title=Genetic Determinants for Body Iron Store and Type 2 Diabetes Risk in US Men and Women
|OA=1
}}

{{PMID|21115529|OA=1
}} Genetics and genomics of human ageing.

{{PMID|22301935}} Association of TMPRSS6 polymorphisms with ferritin, hemoglobin, and type 2 diabetes risk in a Chinese Han population.

{{PMID|22323359}} TMPRSS6, but not TF, TFR2 or BMP2 variants are associated with increased risk of iron-deficiency anemia.

{{GET Evidence
|gene=TMPRSS6
|aa_change=Val736Ala
|aa_change_short=V736A
|impact=not reviewed
|qualified_impact=Insufficiently evaluated not reviewed
|inheritance=unknown
|quality_scores=Array
|dbsnp_id=rs855791
|overall_frequency_n=7093
|overall_frequency_d=10758
|overall_frequency=0.659323
|n_genomes=46
|n_genomes_annotated=0
|n_haplomes=73
|n_articles=0
|n_articles_annotated=0
|gene_in_genetests=Y
|in_gwas=Y
|nblosum100=2
|autoscore=2
|webscore=N
|n_web_uneval=10
}}

{{PMID Auto GWAS
  |PMID=23263863
  |Trait=Hematology traits
  |Title=GWAS of blood cell traits identifies novel associated loci and epistatic interactions in Caucasian and African-American children.
  |RiskAllele=T
  |Pval=3E-8
  |OR=.09
  |ORtxt=[0.058-0.121] unit decrease
  |OA=1
}}

{{PMID Auto GWAS
  |PMID=23222517
  |Trait=Red blood cell traits
  |Title=Seventy-five genetic loci influencing the human red blood cell.
  |RiskAllele=G
  |Pval=1E-69
  |OR=.01
  |ORtxt=[0.0042-0.0198] unit increase
  |OA=1
}}

{{PMID Auto
|PMID=22885719
|Title=Effect of the A736V TMPRSS6 polymorphism on the penetrance and clinical expression of hereditary hemochromatosis.
}}

{{PMID Auto
|PMID=23092954
|Title=SHAVE: shrinkage estimator measured for multiple visits increases power in GWAS of quantitative traits.
|OA=1
}}

{{PMID Auto
|PMID=23794717
|Title=Associations of common variants in HFE and TMPRSS6 with iron parameters are independent of serum hepcidin in a general population: a replication study.
}}

{{PMID Auto
|PMID=24782651
|Title=TMPRSS6 rs855791 Polymorphism Influences the Susceptibility to Iron Deficiency Anemia in Women at Reproductive Age
|OA=1
}}

{{PMID Auto
|PMID=24801367
|Title=A candidate gene approach for identifying differential iron responses in young overweight women to an energy-restricted haem iron-rich diet
}}

{{PMID Auto
|PMID=25085015
|Title=Examination of HFE associations with childhood leukemia risk and extension to other iron regulatory genes
}}
{{on chip | 23andMe v1}}
{{on chip | 23andMe v2}}
{{on chip | 23andMe v3}}
{{on chip | 23andMe v4}}
{{on chip | HumanOmni1Quad}}
{{on chip | Illumina Human 1M}}