{{Rsnum
|rsid=858518
|Gene=SHBG
|Chromosome=17
|position=7629707
|Orientation=plus
|GMAF=0.4256
|Gene_s=SAT2,SHBG
|Assembly=GRCh38
|GenomeBuild=38.1
|dbSNPBuild=141
|geno1=(C;C)
|geno2=(C;T)
|geno3=(T;T)
}}is a SNP in the sex-hormone binding globulin (SHBG) gene. SHBG binds steroid hormones, mostly testosterone and estradiol, rendering them biologically unavailable.

{{PMID|19064566|OA=1
}} Ten SNPs within or close to the SHBG gene were significantly associated with SHBG levels as was the (TAAAA)(n) polymorphism. The best-fitting combination of rs6259, rs858521, and rs727428 and body mass index, waist, hip, age, and smoking status accounted for 24% of the variance in SHBG levels (natural logarithm transformed).