{{Rsnum
|rsid=861539
|Gene=KLC1
|Chromosome=14
|position=103699416
|Orientation=minus
|ReferenceAllele=C
|MissenseAllele=T
|GMAF=0.2507
|Gene_s=KLC1,XRCC3
|Assembly=GRCh38
|GenomeBuild=38.1
|dbSNPBuild=141
|geno1=(C;C)
|geno2=(C;T)
|geno3=(T;T)
}}{{ population diversity
| geno1=(C;C)
| geno2=(C;T)
| geno3=(T;T)
| CEU | 31.0 | 52.2 | 16.8
| HCB | 87.6 | 12.4 | 0.0
| JPT | 77.7 | 21.4 | 0.9
| YRI | 66.0 | 31.9 | 2.1
| ASW | 68.4 | 28.1 | 3.5
| CHB | 87.6 | 12.4 | 0.0
| CHD | 91.7 | 8.3 | 0.0
| GIH | 57.4 | 35.6 | 6.9
| LWK | 58.2 | 36.4 | 5.5
| MEX | 71.9 | 24.6 | 3.5
| MKK | 64.5 | 31.0 | 4.5
| TSI | 32.4 | 43.1 | 24.5
| HapMapRevision=28
}}

18067C>T possibly related to non-Hodgkin lymphoma

{{PMID|18410587}}  [[rs2040639]]-AG, contribute to oral cancer risk. 

pseudo-haplotype with AG-CC genotypes in 
*2.45x risk [[rs2040639]]-[[rs861539]]
*5.03x risk [[rs2040639]]-[[rs861539]]-[[rs2075685]]
*10.10x risk [[rs2040639]]-[[rs861539]]-[[rs2075685]]-[[rs1799782]]

[[rs4880]](C;T) [[prostate cancer]] patients being treated by radiation therapy are more likely (8% compared to 0%, p=0.02) to exhibit a significant increase in grade 2 late rectal bleeding after irradiation than (C;C) or (T;T) patients, based on a study of 135 patients. The odds for this are worse if the patient also has the [[rs861539]](C;T) genotype (14% vs 1%, p=0.002).{{PMID|18582155}}

{{PMID Auto
|PMID=19815090
|Title=The Relation between Endothelial Nitric Oxide Synthase Gene Variants and Primary Open-Angle Glaucoma: Interactions with Gender and Postmenopausal Hormone Use
}}

{{PMID Auto
|PMID=20334523
|Title=Association between Normal Tissue Complications after Radiotherapy and Polymorphic Variations in TGFB1 and XRCC1 Genes
}}
{{PMID Auto
|PMID=20590474
|Title=Polymorphic Variants of DNA Repair Gene XRCC3 and XRCC7 and Risk of Prostate Cancer: A Study from North Indian Population
}}

{{omim
|id=600675
|rsnum=861539
|variant=0001
}}

{{PMID Auto
|PMID=21419115
|Title=DNA Repair Gene ERCC2 Polymorphisms and Risk of Squamous Cell Carcinoma of the Head and Neck
}}

{{PMID Auto
|PMID=21617942
|Title=Gene variants of XRCC4 and XRCC3 and their association with risk for urothelial bladder cancer
}}

{{PMID Auto
|PMID=21725594
|Title=Combined effect of polymorphisms in Rad51 and Xrcc3 on breast cancer risk and chromosomal radiosensitivity
}}

{{PMID Auto
|PMID=22726897
|Title=Single nucleotide polymorphism barcoding to evaluate oral cancer risk using odds ratio-based genetic algorithms
}}

{{ClinVar
|rsid=861539
|Reversed=1
|FwdREF=C
|FwdALT=T
|REF=G
|ALT=A
|RSPOS=104165753
|CHROM=14
|GMAF=0.25
|dbSNPBuildID=86
|SSR=0
|SAO=1
|VP=0x05036800000015051f110101
|GENEINFO=KLC1:3831; XRCC3:7517
|GENE_NAME=KLC1; XRCC3
|GENE_ID=3831; 7517
|WGT=0
|VC=SNV
|CLNALLE=1
|CLNHGVS=NC_000014.8:g.104165753G>A
|CLNSRC=OMIM Allelic Variant
|CLNORIGIN=1
|CLNSRCID=600675.0001
|CLNSIG=255
|CLNCUI=C3151417
|CLNDBN=Cutaneous malignant melanoma 6
|Disease=Cutaneous malignant melanoma 6
|CLNACC=RCV000009500.1
|Tags=RV;PM;PMC;S3D;SLO;VLD;G5;HD;GNO;KGPhase1;KGPilot123;KGPROD;OTHERKG;PH3;LSD;OM
|CAF=0.7493; 0.2507
|CLNDSDB=MedGen:OMIM:Orphanet
|CLNDSDBID=C3151417:613972:618
|COMMON=1
}}

{{PMID Auto
|PMID=16465622
|Title=Bladder cancer predisposition: a multigenic approach to DNA-repair and cell-cycle-control genes.
|OA=1
}}

{{PMID Auto
|PMID=16857995
|Title=Risk of non-Hodgkin lymphoma (NHL) in relation to germline variation in DNA repair and related genes.
|OA=1
}}

{{PMID Auto
|PMID=17557904
|Title=Evaluation of genetic variation in the double-strand break repair pathway and bladder cancer risk.
}}

{{PMID Auto
|PMID=17705814
|Title=Polymorphisms in XPC, XPD, XRCC1, and XRCC3 DNA repair genes and lung cancer risk in a population of northern Spain.
|OA=1
}}

{{PMID Auto
|PMID=18086758
|Title=Association between single-nucleotide polymorphisms in hormone metabolism and DNA repair genes and epithelial ovarian cancer: results from two Australian studies and an additional validation set.
|OA=1
}}

{{PMID Auto
|PMID=18188695
|Title=Genetic polymorphisms in the DNA repair genes XRCC1, XRCC2 and XRCC3 and risk of breast cancer in Cyprus.
}}

{{PMID Auto
|PMID=18191955
|Title=Correlating observed odds ratios from lung cancer case-control studies to SNP functional scores predicted by bioinformatic tools.
|OA=1
}}

{{PMID Auto
|PMID=18194558
|Title=A hierarchical and modular approach to the discovery of robust associations in genome-wide association studies from pooled DNA samples.
|OA=1
}}

{{PMID Auto
|PMID=18579371
|Title=Genetic polymorphisms in double-strand break DNA repair genes associated with risk of oral premalignant lesions.
|OA=1
}}

{{PMID Auto
|PMID=18701435
|Title=Polygenic model of DNA repair genetic polymorphisms in human breast cancer risk.
|OA=1
}}

{{PMID Auto
|PMID=18708406
|Title=Variants of DNA repair genes and the risk of biliary tract cancers and stones: a population-based study in China.
|OA=1
}}

{{PMID Auto
|PMID=18768505
|Title=Genetic susceptibility to renal cell carcinoma: the role of DNA double-strand break repair pathway.
|OA=1
}}

{{PMID Auto
|PMID=18990748
|Title=International Lung Cancer Consortium: pooled analysis of sequence variants in DNA repair and cell cycle pathways.
|OA=1
}}

{{PMID Auto
|PMID=19124499
|Title=Association and interactions between DNA repair gene polymorphisms and adult glioma.
|OA=1
}}

{{PMID Auto
|PMID=19127255
|Title=Validating genetic risk associations for ovarian cancer through the international Ovarian Cancer Association Consortium.
|OA=1
}}

{{PMID Auto
|PMID=19367277
|Title=Genetic polymorphisms in DNA repair and damage response genes and late normal tissue complications of radiotherapy for breast cancer.
|OA=1
}}

{{PMID Auto
|PMID=19706757
|Title=Polymorphisms in DNA repair genes, smoking, and bladder cancer risk: findings from the international consortium of bladder cancer.
|OA=1
}}

{{PMID Auto
|PMID=20004634
|Title=Breast cancer risk and common single nucleotide polymorphisms in homologous recombination DNA repair pathway genes XRCC2, XRCC3, NBS1 and RAD51.
}}

{{PMID Auto
|PMID=21104022
|Title=Polymorphisms in RAD51, XRCC2 and XRCC3 genes of the homologous recombination repair in colorectal cancer--a case control study.
|OA=1
}}

{{PMID Auto
|PMID=21183201
|Title=DNA repair gene polymorphisms at XRCC1, XRCC3, XPD, and OGG1 loci in Maharashtrian population of central India.
}}

{{PMID Auto
|PMID=21195504
|Title=Association of genetic polymorphisms in DNA repair pathway genes with non-small cell lung cancer risk.
}}

{{PMID Auto
|PMID=21347786
|Title=DNA repair gene and MTHFR gene polymorphisms as prognostic markers in locally advanced adenocarcinoma of the esophagus or stomach treated with cisplatin and 5-fluorouracil-based neoadjuvant chemotherapy.
}}

{{PMID Auto
|PMID=21561390
|Title=Association of APE1 and hOGG1 polymorphisms with colorectal cancer risk in a Turkish population.
}}

{{PMID Auto
|PMID=21974800
|Title=DNA repair gene polymorphisms and risk of early onset colorectal cancer in Lynch syndrome.
}}

{{PMID Auto
|PMID=22525558
|Title=Genetic polymorphisms involved in carcinogen metabolism and DNA repair and lung cancer risk in a Japanese population.
}}

{{PMID Auto
|PMID=23244079
|Title=Comprehensive Study on Associations Between Nine SNPs and Glioma Risk
}}

{{PMID Auto
|PMID=23539294
|Title=XRCC2 R188H (rs3218536), XRCC3 T241M (rs861539) and R243H (rs77381814) Single Nucleotide Polymorphisms in Cervical Cancer Risk
}}

{{PMID Auto
|PMID=24085356
|Title=Genetic polymorphisms of XRCC3 Thr241Met (C18067T, rs861539) and bladder cancer risk: a meta-analysis of 18 research studies
}}

{{PMID Auto
|PMID=24307625
|Title=Haplotype-based case-control study of DNA repair gene XRCC3 and hepatocellular carcinoma risk in a Chinese population
}}

{{PMID Auto
|PMID=24325908
|Title=Analysis of dna repair gene polymorphisms in glioblastoma
}}

{{PMID Auto
|PMID=24500421
|Title=Association between DNA repair gene polymorphisms and risk of glioma: A systematic review and meta-analysis
}}

{{PMID Auto
|PMID=22740138
|Title=An interethnic variability and a functional prediction of DNA repair gene polymorphisms: the example of XRCC3 (p.Thr241>Met) and XPD (p.Lys751>Gln) in a healthy Tunisian population.
}}

{{PMID Auto
|PMID=23271134
|Title=Association between XRCC1 and XRCC3 polymorphisms and colorectal cancer risk: a meta-analysis of 23 case-control studies.
}}

{{PMID Auto
|PMID=23526128
|Title=Lack of association between XRCC3 rs861539 (C > T) polymorphism and lung cancer risks: an update meta-analysis.
}}

{{PMID Auto
|PMID=24922659
|Title=Contribution of DNA Double-strand Break Repair Gene XRCC3 Genotypes to Oral Cancer Susceptibility in Taiwan
}}

{{PMID Auto
|PMID=24940494
|Title=Association of XRCC1 and XRCC3 gene haplotypes with the development of radiation-induced fibrosis in patients with nasopharyngeal carcinoma
}}

{{PMID Auto
|PMID=24939416
|Title=CYP1A1 Ile462Val polymorphism and colorectal cancer risk in Polish patients
}}

{{PMID Auto
|PMID=25006581
|Title=Analyzing Association of the XRCC3 Gene Polymorphism with Ovarian Cancer Risk
}}

{{PMID Auto
|PMID=25176580
|Title=NBN and XRCC3 genetic variants in childhood acute lymphoblastic leukaemia
}}
{{on chip | 23andMe v2}}
{{on chip | 23andMe v3}}
{{on chip | 23andMe v4}}
{{on chip | FTDNA2}}
{{on chip | HumanOmni1Quad}}
{{on chip | Illumina Human 1M}}