{{Rsnum
|rsid=867186
|Gene=PROCR
|Chromosome=20
|position=35176751
|Orientation=plus
|ReferenceAllele=A
|MissenseAllele=G
|GMAF=0.08402
|Assembly=GRCh38
|GenomeBuild=38.1
|dbSNPBuild=141
|geno1=(A;A)
|geno2=(A;G)
|geno3=(G;G)
|Gene_s=PROCR
}}{{ population diversity
| geno1=(A;A)
| geno2=(A;G)
| geno3=(G;G)
| CEU | 81.4 | 17.7 | 0.9
| HCB | 92.0 | 8.0 | 0.0
| JPT | 88.5 | 11.5 | 0.0
| YRI | 85.0 | 15.0 | 0.0
| ASW | 86.0 | 14.0 | 0.0
| CHB | 92.0 | 8.0 | 0.0
| CHD | 81.7 | 17.4 | 0.9
| GIH | 72.3 | 26.7 | 1.0
| LWK | 80.0 | 18.2 | 1.8
| MEX | 86.2 | 12.1 | 1.7
| MKK | 81.4 | 18.6 | 0.0
| TSI | 80.4 | 18.6 | 1.0
| HapMapRevision=28
}}
[[rs867186]] is a SNP that can indicate haplotype H3 of the [[EPCR]] gene. The protein product of the [[EPCR]] gene activates a part of the anticoagulation pathway. While the [[rs867186]](A) allele could indicate haplotypes H1, H2 or H4, the [[rs867186]](G) allele distinctly tags (identifies) the H3 haplotype.{{PMID|17849044}}

While most groups studying [[EPCR]] H3 agree that it leads to increased soluble EPCR, and thus should theoretically lead to reduced risk for [[venous thromboembolism]], different groups come to different conclusions about the effect in the populations each studies. Two find no association [PMID 15304035, PMID 15116250] while one finds that the H3 haplotype (and thus [[rs867186]](G)) actually increases the risk of venous thromboembolism (VTE), with an odds ratio of 1.80, p=0.004.{{PMID|14576048}}

{{ neighbor
| rsid = 9574
| distance = 78
}}

{{PMID Auto GWAS
|PMID=20231535
|Trait=Plasma coagulation factors
|Title=Novel Associations of Multiple Genetic Loci With Plasma Levels of Factor VII, Factor VIII, and von Willebrand Factor. The CHARGE (Cohorts for Heart and Aging Research in Genome Epidemiology) Consortium
|RiskAllele=G
|Pval=6E-37
|OR=None
|ORtxt=None
|OA=1
}}
{{PMID Auto GWAS
|PMID=20802025
|Trait=None
|Title=Genome-wide association study identifies novel loci for plasma levels of protein C: the ARIC study
|RiskAllele=C
|Pval=0
|OR=0.47
|ORtxt=[0.44-0.50] ug/ml increase
|OA=1
}}

{{PMID Auto GWAS
|PMID=21502573
|Trait=None
|Title=Genetic predictors of fibrin D-dimer levels in healthy adults.
|RiskAllele=G
|Pval=0.000004
|OR=0.0484
|ORtxt=[NR] % increase
|OA=1
}}

{{PMID Auto GWAS
|PMID=22216198
|Trait=None
|Title=A genome-wide association study of the Protein C anticoagulant pathway.
|RiskAllele=G
|Pval=4E-9
|OR=0.8450
|ORtxt=None
|OA=1
}}

{{PMID Auto
|PMID=22443383
|Title=Genome wide association study for plasma levels of natural anticoagulant inhibitors and protein C anticoagulant pathway: the MARTHA project
}}

{{PMID Auto
|PMID=16846490
|Title=Lemierre's syndrome and genetic polymorphisms: a case report.
|OA=1
}}

{{PMID Auto
|PMID=18680534
|Title=PROC, PROCR and PROS1 polymorphisms, plasma anticoagulant phenotypes, and risk of cardiovascular disease and mortality in older adults: the Cardiovascular Health Study.
|OA=1
}}

{{PMID Auto
|PMID=18947391
|Title=Hemostasis and ageing.
|OA=1
}}

{{PMID Auto
|PMID=22251481
|Title=The endothelial protein C receptor (PROCR) Ser219Gly variant and risk of common thrombotic disorders: a HuGE review and meta-analysis of evidence from observational studies.
|OA=1
}}

{{GET Evidence
|gene=PROCR
|aa_change=Ser219Gly
|aa_change_short=S219G
|impact=not reviewed
|qualified_impact=Insufficiently evaluated not reviewed
|inheritance=unknown
|quality_scores=Array
|dbsnp_id=rs867186
|overall_frequency_n=1071
|overall_frequency_d=10758
|overall_frequency=0.0995538
|n_genomes=11
|n_genomes_annotated=0
|n_haplomes=10
|n_articles=0
|n_articles_annotated=0
|pph2_score=0.588
|nblosum100=2
|autoscore=0
|webscore=N
}}

{{PMID Auto
|PMID=23136988
|Title=Association of soluble endothelial protein C receptor plasma levels and PROCR rs867186 with cardiovascular risk factors and cardiovascular events in coronary artery disease patients: The AtheroGene Study
|OA=1
}}

{{on chip | 23andMe v1}}
{{on chip | 23andMe v2}}
{{on chip | 23andMe v3}}
{{on chip | 23andMe v4}}
{{on chip | Affy GenomeWide 6}}
{{on chip | FTDNA2}}
{{on chip | FTDNA}}
{{on chip | HumanOmni1Quad}}
{{on chip | Illumina Human 1M}}