{{Rsnum
|rsid=870849
|Gene=LAG3
|Chromosome=12
|position=6777854
|Orientation=plus
|ReferenceAllele=T
|MissenseAllele=C
|GMAF=0.3356
|Assembly=GRCh38
|GenomeBuild=38.1
|dbSNPBuild=141
|geno1=(C;C)
|geno2=(C;T)
|geno3=(T;T)
|Gene_s=LAG3
}}{{ population diversity
| geno1=(C;C)
| geno2=(C;T)
| geno3=(T;T)
| CEU | 31.9 | 55.8 | 12.4
| HCB | 65.7 | 32.8 | 1.5
| JPT | 61.6 | 38.4 | 0.0
| YRI | 38.1 | 43.5 | 18.4
| ASW | 24.6 | 52.6 | 22.8
| CHB | 65.7 | 32.8 | 1.5
| CHD | 67.0 | 30.3 | 2.8
| GIH | 44.6 | 46.5 | 8.9
| LWK | 32.7 | 46.4 | 20.9
| MEX | 57.9 | 35.1 | 7.0
| MKK | 41.7 | 42.9 | 15.4
| TSI | 34.3 | 43.1 | 22.5
| HapMapRevision=28
}}[[rs870849]], a SNP in the [[LAG3]] gene, has been associated with [[multiple sclerosis]]. {{PMID|15674389}}

{{PMID|16519819|OA=1
}} Analysis of polymorphisms in 16 genes in type 1 diabetes that have been associated with other immune-mediated diseases.

{{PMID|17708757|OA=1
}} Genome bioinformatic analysis of nonsynonymous SNPs.

{{GET Evidence
|gene=LAG3
|aa_change=Ile455Thr
|aa_change_short=I455T
|impact=not reviewed
|qualified_impact=Insufficiently evaluated not reviewed
|inheritance=unknown
|quality_scores=Array
|dbsnp_id=rs870849
|overall_frequency_n=6403
|overall_frequency_d=10758
|overall_frequency=0.595185
|n_genomes=44
|n_genomes_annotated=0
|n_haplomes=66
|n_articles=0
|n_articles_annotated=0
|nblosum100=3
|autoscore=0
|webscore=N
}}

{{on chip | 23andMe v1}}
{{on chip | 23andMe v2}}
{{on chip | 23andMe v3}}
{{on chip | 23andMe v4}}
{{on chip | FTDNA2}}
{{on chip | HumanOmni1Quad}}
{{on chip | Illumina Human 1M}}