{{Rsnum
|rsid=874881
|Gene=PADI4
|Chromosome=1
|position=17334004
|Orientation=plus
|ReferenceAllele=C
|MissenseAllele=G
|GMAF=0.4908
|Assembly=GRCh38
|GenomeBuild=38.1
|dbSNPBuild=141
|geno1=(C;C)
|geno2=(C;G)
|geno3=(G;G)
|Gene_s=PADI4
}}{{ population diversity
| geno1=(C;C)
| geno2=(C;G)
| geno3=(G;G)
| CEU | 30.8 | 49.2 | 20.0
| HCB | 35.6 | 46.7 | 17.8
| JPT | 31.8 | 45.5 | 22.7
| YRI | 12.7 | 52.4 | 34.9
| ASW | 0.0 | 0.0 | 0.0
| CHB | 35.6 | 46.7 | 17.8
| CHD | 0.0 | 0.0 | 0.0
| GIH | 0.0 | 0.0 | 0.0
| LWK | 0.0 | 0.0 | 0.0
| MEX | 0.0 | 0.0 | 0.0
| MKK | 0.0 | 0.0 | 0.0
| TSI | 0.0 | 0.0 | 0.0
| HapMapRevision=28
}}

{{Venter SNP
|rsid=874881
|allele=C
|frequency=0.45
|uid=1103675033977
|type=heterozygous_SNP
|hugo=PADI4
|ensembl gene=ENSG00000159339
|ensembl transcript=ENST00000290507
|sift=TOLERATED
|disease=PADI4 is thought to be a rheumatoid arthritis susceptibility locus (MIM:180300). Could have an important role in the pathogenesis of rheumatoid arthritis by increasing citrullination of proteins in rheumatoid arthritis synovial tissues, leading, in a cytokine-rich milieu, to a break in tolerance to citrullinated peptides processed and presented in the appropriate HLA context.
}}

{{PMID Auto
|PMID=20563870
|Title=The PADI4 gene does not contribute to genetic susceptibility to rheumatoid arthritis in Chinese Han population
}}

{{PMID Auto
|PMID=18576335
|Title=Association of autoimmunity to peptidyl arginine deiminase type 4 with genotype and disease severity in rheumatoid arthritis.
|OA=1
}}

{{PMID Auto
|PMID=20537173
|Title=Peptidyl arginine deiminase type IV (PADI4) haplotypes interact with shared epitope regardless of anti-cyclic citrullinated peptide antibody or erosive joint status in rheumatoid arthritis: a case control study.
|OA=1
}}

{{PMID Auto
|PMID=21039740
|Title=PADI4 gene polymorphism is not associated with ankylosing spondylitis in Chinese Han population.
}}

{{PMID Auto
|PMID=22505706
|Title=Peptidylarginine deiminase type 4 and methyl-CpG binding domain 4 polymorphisms in Chinese patients with rheumatoid arthritis.
}}

{{PMID Auto
|PMID=22976394
|Title=Association of single nucleotide polymorphisms (SNPs) of PADI4 gene with rheumatoid arthritis (RA) in Indian population
}}

{{GET Evidence
|gene=PADI4
|aa_change=Gly112Ala
|aa_change_short=G112A
|impact=not reviewed
|qualified_impact=Insufficiently evaluated not reviewed
|inheritance=unknown
|quality_scores=Array
|dbsnp_id=rs874881
|overall_frequency_n=5682
|overall_frequency_d=10758
|overall_frequency=0.528165
|n_genomes=35
|n_genomes_annotated=0
|n_haplomes=43
|n_articles=0
|n_articles_annotated=0
|pph2_score=0.077
|nblosum100=1
|autoscore=0
|webscore=N
}}

{{PMID Auto
|PMID=23450494
|Title=[Association of polymorphisms of PTPN22 and PADI4 genes with rheumatoid arthritis in Yunnan]
}}

{{on chip | 23andMe v3}}
{{on chip | 23andMe v4}}
{{on chip | FTDNA2}}
{{on chip | HumanOmni1Quad}}
{{on chip | Illumina Human 1M}}