{{Rsnum
|rsid=887829
|Gene=UGT1A10
|Chromosome=2
|position=233759924
|Orientation=minus
|GMAF=0.3108
|Gene_s=UGT1A1,UGT1A3,UGT1A4,UGT1A5,UGT1A6,UGT1A7,UGT1A8,UGT1A9,UGT1A10
|Assembly=GRCh38
|GenomeBuild=38.1
|dbSNPBuild=141
|geno1=(A;A)
|geno2=(A;G)
|geno3=(G;G)
}}[[rs887829]] is a SNP in the [[UGT1A1]] gene. The minor allele of this SNP has been reported to be associated with higher levels of serum bilirubin, which has an inverse correlation with [[coronary artery disease]].
{{ population diversity
| geno1=(A;A)
| geno2=(A;G)
| geno3=(G;G)
| CEU | 8.0 | 46.9 | 45.1
| HCB | 1.5 | 22.6 | 75.9
| JPT | 5.3 | 23.9 | 70.8
| YRI | 26.5 | 46.3 | 27.2
| ASW | 14.0 | 63.2 | 22.8
| CHB | 1.5 | 22.6 | 75.9
| CHD | 1.8 | 24.8 | 73.4
| GIH | 22.0 | 45.0 | 33.0
| LWK | 20.9 | 60.0 | 19.1
| MEX | 6.9 | 48.3 | 44.8
| MKK | 23.1 | 50.6 | 26.3
| TSI | 8.8 | 40.2 | 51.0
| HapMapRevision=28
}}
{{PMID Auto
|PMID=19238116
|Title=Common variants of four bilirubin metabolism genes and their association with serum bilirubin and coronary artery disease in Chinese Han population
}}. This study of 2,000+ patients reports a recessive protective effect against [[coronary artery disease]] for the minor allele, with an age-adjusted odds ratio of 0.24 (CI: 0.10-0.60, p=0.0014).

{{PMID Auto GWAS
|PMID=19419973
|Trait=Bilirubin levels
|Title=Common variants in the SLCO1B3 locus are associated with bilirubin levels and unconjugated hyperbilirubinemia
|RiskAllele=T
|Pval=1E-69
|OR=0.57
|ORtxt=[0.50-0.63] SD decrease
|OA=1
}}

{{PharmGKB
|RSID=rs887829
|Name_s=
|Gene_s=UGT1A10, UGT1A3, UGT1A4, UGT1A5, UGT1A6, UGT1A7, UGT1A8, UGT1A9, UGT1A1
|Feature=Intron, Intron, Intron, Intron, Intron, Intron, Intron, Intron, Intron
|Evidence=PubMed ID:19419973
|Annotation=This variant is in the promoter region of UGT1A1 and associated with serum bilirubin levels and hyperbilirubinemia in a genome wide association scan from 4300 Sardinian individuals.
|Drugs=
|Drug Classes=
|Diseases=Hyperbilirubinemia
|Curation Level=Curated
|PharmGKB Accession ID=PA164758019
}}

{{PMID Auto
|PMID=21309756
|Title=Prevalence of clinically relevant UGT1A alleles and haplotypes in African populations
}}

{{PMID Auto
|PMID=22085899
|Title=UGT1A1 is a major locus influencing bilirubin levels in African Americans
|OA=1
}}

{{PMID Auto GWAS
|PMID=21886157
|Trait=None
|Title=Human metabolic individuality in biomedical and pharmaceutical research.
|RiskAllele=T
|Pval=3E-74
|OR=0.2930
|ORtxt=None
|OA=1
}}

{{PMID Auto GWAS
|PMID=22558097
|Trait=None
|Title=A genome-wide association study of total bilirubin and cholelithiasis risk in sickle cell anemia.
|RiskAllele=A
|Pval=5E-25
|OR=0.1900
|ORtxt=None
|OA=1
}}

{{PMID Auto
|PMID=17424838
|Title=[Genetic polymorphisms of MPO, NQO1, GSTP1, UGT1A6 associated with susceptibility of chronic benzene poisoning].
}}

{{PMID Auto
|PMID=18349273
|Title=UGT1A1 genetic polymorphisms, endogenous estrogen exposure, soy food intake, and endometrial cancer risk.
}}

{{PMID Auto
|PMID=19267064
|Title=[Relationship between genetic polymorphisms of phase I and phase II metabolizing enzymes and DNA damage of workers exposed to vinyl chloride monomer].
}}

{{PMID Auto
|PMID=19414484
|Title=Genome-wide association meta-analysis for total serum bilirubin levels.
|OA=1
}}

{{PMID Auto
|PMID=19482841
|Title=Serum bilirubin levels on ICU admission are associated with ARDS development and mortality in sepsis.
|OA=1
}}

{{GET Evidence
|impact=pathogenic
|qualified_impact=Insufficiently evaluated pathogenic
|inheritance=unknown
|quality_scores=Array
|dbsnp_id=rs887829
|overall_frequency_n=39
|overall_frequency_d=110
|overall_frequency=0.354545
|n_genomes=31
|n_genomes_annotated=0
|n_haplomes=36
|n_articles=1
|n_articles_annotated=0
|in_gwas=Y
|in_pharmgkb=Y
|autoscore=2
|webscore=N
}}

{{PMID Auto GWAS
  |PMID=23281178
  |Trait=Metabolite levels
  |Title=A genome-wide assessment of variability in human serum metabolism.
  |RiskAllele=T
  |Pval=9E-25
  |OR=NR
  |ORtxt=NR
  }}

{{PMID Auto
|PMID=23642732
|Title=Association of SNPs in the UGT1A gene cluster with total bilirubin and mortality in the Diabetes Heart Study
}}

{{PMID Auto
|PMID=23092954
|Title=SHAVE: shrinkage estimator measured for multiple visits increases power in GWAS of quantitative traits.
|OA=1
}}

{{on chip | 23andMe v2}}
{{on chip | 23andMe v3}}
{{on chip | 23andMe v4}}
{{on chip | Affy GenomeWide 6}}
{{on chip | HumanOmni1Quad}}
{{on chip | Illumina Human 1M}}