{{Rsnum
|rsid=889312
|Chromosome=5
|position=56736057
|Orientation=plus
|GMAF=0.3898
|Assembly=GRCh38
|GenomeBuild=38.1
|dbSNPBuild=141
|geno1=(A;A)
|geno2=(A;C)
|geno3=(C;C)
}}{{ population diversity
| geno1=(A;A)
| geno2=(A;C)
| geno3=(C;C)
| CEU | 47.7 | 44.6 | 7.7
| HCB | 27.3 | 45.5 | 27.3
| JPT | 13.6 | 63.6 | 22.7
| YRI | 47.5 | 42.6 | 9.8
| ASW | 0.0 | 0.0 | 0.0
| CHB | 27.3 | 45.5 | 27.3
| CHD | 0.0 | 0.0 | 0.0
| GIH | 0.0 | 0.0 | 0.0
| LWK | 0.0 | 0.0 | 0.0
| MEX | 0.0 | 0.0 | 0.0
| MKK | 0.0 | 0.0 | 0.0
| TSI | 0.0 | 0.0 | 0.0
| HapMapRevision=28
}}
[[rs889312]] is a SNP near the [[MAP3K1]] gene.

[[rs889312]] was one of the four strongest associating SNPs found in a genome-wide association study of over 4,000 [[breast cancer]] samples. {{PMID|17529967|OA=1
}}. From a DeCode user report, it appears that the risk allele is C; this A;A individual reportedly has 0.93x risk of [[breast cancer]]. {{PMID|17529967|OA=1
}}

In a study of 1,267 [[breast cancer]] patients, [[rs889312]] heterozygotes and minor allele homozygotes were less likely to be lymph node positive at breast cancer diagnosis (P = 0.044) relative to major allele homozygote carriers. {{PMID|17997823|OA=1
}}

A meta-analysis including 26,015 cases and 33,962 controls concludes that the [[rs889312]](C) allele is clearly a significant - but quite weak - contributor to increased risk for [[breast cancer]].{{PMID|20809358}}

{{PMID|18437204|OA=1
}} [[breast cancer]]
*[[rs2981582]], [[rs3803662]], and [[rs889312]]) showed weak but significant associations with ER-negative disease, the strongest association being for rs3803662 in TNRC9 (1.14 (1.09-1.21))

{{GWAS Summary
|SNP=rs889312
|PubMedID=17529967
|Condition=Breast cancer
|Gene=MAP3K1
|Risk Allele=A
|pValue=7.00E-020
|OR=1.13
|95CI=1.10-1.16
|OA=1
}}

{{omim
|desc=BREAST CANCER
|id=114480
|rsnum=889312
}}

{{omim
|desc=MITOGEN-ACTIVATED KINASE KINASE KINASE 1; MAP3K1
|id=600982
|rsnum=889312
}}
{{PMID Auto
|PMID=19843670
|Title=Association of Breast Cancer Susceptibility Variants with Risk of Pancreatic Cancer
|OA=1
}}

{{PharmGKB
|RSID=rs889312
|Name_s=
|Gene_s=-
|Feature=
|Evidence=PubMed ID:17529967; Web Resource:http://www.genome.gov/gwastudies/
|Annotation=GWAS Results: Genome-wide association study identifies novel breast cancer susceptibility loci (Initial Sample Size: 390 cases, 364 controls; Replication Sample Size: 26,646 cases, 24,889 controls; Risk Allele: rs889312-A).
|Drugs=
|Drug Classes=
|Diseases=Breast Neoplasms
|Curation Level=Non-Curated
|PharmGKB Accession ID=PA162356625
}}

{{PMID Auto
|PMID=20145138
|Title=Common genetic variants associated with breast cancer and mammographic density measures that predict disease
}}
{{PMID Auto GWAS
|PMID=20453838
|Trait=Breast cancer
|Title=Genome-wide association study identifies five new breast cancer susceptibility loci
|RiskAllele=C
|Pval=5E-9
|OR=1.22
|ORtxt=[1.14-1.30]
|OA=1
}}
{{PMID Auto
|PMID=20054709
|Title=Birth weight, breast cancer susceptibility loci, and breast cancer risk
}}
{{PMID Auto
|PMID=20699374
|Title=Evaluation of Breast Cancer Susceptibility Loci in Chinese Women
|OA=1
}}

{{PharmGKB
|RSID=rs889312
|Name_s=
|Gene_s=-
|Feature=
|Evidence=PubMed ID:17529967; PubMed ID:17997823
|Annotation=This variant is significantly associated with risk for breast cancer.
|Drugs=
|Drug Classes=
|Diseases=Breast Neoplasms
|Curation Level=Curated
|PharmGKB Accession ID=PA161925627
}}

{{PharmGKB
|RSID=rs889312
|Name_s=
|Gene_s=-
|Feature=
|Evidence=PubMed ID:18355772
|Annotation=The minor allele of this SNP has been associated with increased risk of breast cancer in BRCA2 mutation carriers.
|Drugs=
|Drug Classes=
|Diseases=Breast Neoplasms
|Curation Level=Curated
|PharmGKB Accession ID=PA161615668
}}
{{PMID Auto
|PMID=21197568
|Title=Risk of genome-wide association study newly identified genetic variants for breast cancer in Chinese women of Heilongjiang Province
}}

{{PMID Auto
|PMID=21415360
|Title=Common genetic variants associated with breast cancer in Korean women and differential susceptibility according to intrinsic subtype
}}

{{PMID Auto
|PMID=21445572
|Title=Genetic polymorphisms and breast cancer risk: evidence from meta-analyses, pooled analyses, and genome-wide association studies
}}

{{PMID Auto
|PMID=21475998
|Title=Replication of five GWAS-identified loci and breast cancer risk among Hispanic and non-Hispanic white women living in the Southwestern United States
|OA=1
}}

{{PMID Auto
|PMID=21791674
|Title=Interactions Between Genetic Variants and Breast Cancer Risk Factors in the Breast and Prostate Cancer Cohort Consortium
|OA=1
}}

{{PMID|21996731}} Relevant data indicate that SNP rs889312 in MAP3K1 is correlated with BC susceptibility only in [[BRCA2]] mutation carriers, but is not associated with an increased risk in BRCA1 carriers.

{{PMID Auto
|PMID=22452962
|Title=A genome-wide association study identifies a breast cancer risk variant in ERBB4 at 2q34: results from the Seoul Breast Cancer Study
|OA=1
}}

{{PMID Auto
|PMID=22468730
|Title=Multilocus Analysis of Candidate Genes Involved in Neurogenic Inflammation in Pediatric Asthma and Related Phenotypes: A Case-Control Study
}}

{{PMID Auto
|PMID=18224312
|Title=Pharmacogenetics: data, concepts and tools to improve drug discovery and drug treatment.
|OA=1
}}

{{PMID Auto
|PMID=18612136
|Title=Discriminatory accuracy from single-nucleotide polymorphisms in models to predict breast cancer risk.
|OA=1
}}

{{PMID Auto
|PMID=18681954
|Title=Breast cancer susceptibility loci and mammographic density.
|OA=1
}}

{{PMID Auto
|PMID=18708391
|Title=Breast cancer risk polymorphisms and interaction with ionizing radiation among U.S. radiologic technologists.
|OA=1
}}

{{PMID Auto
|PMID=18772892
|Title=Can genes for mammographic density inform cancer aetiology?
|OA=1
}}

{{PMID Auto
|PMID=18785201
|Title=Novel breast cancer risk alleles and endometrial cancer risk.
|OA=1
}}

{{PMID Auto
|PMID=18973230
|Title=Breast cancer susceptibility alleles and ovarian cancer risk in 2 study populations.
|OA=1
}}

{{PMID Auto
|PMID=19028704
|Title=Hormone-dependent effects of FGFR2 and MAP3K1 in breast cancer susceptibility in a population-based sample of post-menopausal African-American and European-American women.
|OA=1
}}

{{PMID Auto
|PMID=19088016
|Title=Genetic susceptibility loci for breast cancer by estrogen receptor status.
|OA=1
}}

{{PMID Auto
|PMID=19094228
|Title=The influence of genetic variation in 30 selected genes on the clinical characteristics of early onset breast cancer.
|OA=1
}}

{{PMID Auto
|PMID=19232126
|Title=Association between breast cancer susceptibility loci and mammographic density: the Multiethnic Cohort.
|OA=1
}}

{{PMID Auto
|PMID=19304784
|Title=Association between invasive ovarian cancer susceptibility and 11 best candidate SNPs from breast cancer genome-wide association study.
|OA=1
}}

{{PMID Auto
|PMID=19567422
|Title=Risk of estrogen receptor-positive and -negative breast cancer and single-nucleotide polymorphism 2q35-rs13387042.
|OA=1
}}

{{PMID Auto
|PMID=19639606
|Title=Correcting "winner's curse" in odds ratios from genomewide association findings for major complex human diseases.
|OA=1
}}

{{PMID Auto
|PMID=19931039
|Title=Using lifetime risk estimates in personal genomic profiles: estimation of uncertainty.
|OA=1
}}

{{PMID Auto
|PMID=20146796
|Title=Familial relative risks for breast cancer by pathological subtype: a population-based cohort study.
|OA=1
}}

{{PMID Auto
|PMID=20237344
|Title=Performance of common genetic variants in breast-cancer risk models.
|OA=1
}}

{{PMID Auto
|PMID=20484103
|Title=Genetic and clinical predictors for breast cancer risk assessment and stratification among Chinese women.
|OA=1
}}

{{PMID Auto
|PMID=20605201
|Title=Gene-environment interactions in 7610 women with breast cancer: prospective evidence from the Million Women Study.
|OA=1
}}

{{PMID Auto
|PMID=21596841
|Title=Low penetrance breast cancer susceptibility loci are associated with specific breast tumor subtypes: findings from the Breast Cancer Association Consortium.
|OA=1
}}

{{PMID Auto
|PMID=22045194
|Title=Combined effect of low-penetrant SNPs on breast cancer risk.
|OA=1
}}

{{PMID Auto
|PMID=22532573
|Title=The role of genetic breast cancer susceptibility variants as prognostic factors.
|OA=1
}}

{{GET Evidence
|impact=pathogenic
|qualified_impact=Insufficiently evaluated pathogenic
|inheritance=unknown
|quality_scores=Array
|dbsnp_id=rs889312
|overall_frequency_n=83
|overall_frequency_d=126
|overall_frequency=0.65873
|n_genomes=48
|n_genomes_annotated=0
|n_haplomes=71
|n_articles=1
|n_articles_annotated=0
|in_gwas=Y
|in_pharmgkb=Y
|autoscore=2
|webscore=N
}}

{{PMID Auto
|PMID=23225170
|Title=Genetic variants in FGFR2 and MAP3K1 are associated with the risk of familial and early-onset breast cancer in a South-American population
}}

{{PMID Auto GWAS
  |PMID=23535729
  |Trait=Breast cancer
  |Title=Large-scale genotyping identifies 41 new loci associated with breast cancer risk.
  |RiskAllele=C
  |Pval=3E-36
  |OR=1.12
  |ORtxt=[1.10-1.15]
  |OA=1
}}

{{PMID Auto
|PMID=24340245
|Title=Adiposity, inflammation, genetic variants and risk of post-menopausal breast cancer findings from a prospective-specimen-collection, retrospective-blinded-evaluation (PRoBE) design approach
|OA=1
}}

{{PMID Auto
|PMID=22910930
|Title=Genome-Wide Association Studies (GWAS) breast cancer susceptibility loci in Arabs: susceptibility and prognostic implications in Tunisians.
|OA=1
}}

{{PMID Auto
|PMID=23577780
|Title=Associations between single-nucleotide polymorphisms and epidural ropivacaine consumption in patients undergoing breast cancer surgery.
}}

{{PMID Auto
|PMID=24759887
|Title=A MAP3k1 SNP Predicts Survival of Gastric Cancer in a Chinese Population
|OA=1
}}

{{on chip | 23andMe v2}}
{{on chip | 23andMe v3}}
{{on chip | 23andMe v4}}
{{on chip | HumanOmni1Quad}}