{{Rsnum
|rsid=891512
|Gene=NOS3
|Chromosome=7
|position=151011001
|Orientation=plus
|GMAF=0.1244
|Gene_s=NOS3
|Assembly=GRCh38
|GenomeBuild=38.1
|dbSNPBuild=141
|geno1=(A;A)
|geno2=(A;G)
|geno3=(G;G)
}}
{{ population diversity
| geno1=(A;A)
| geno2=(A;G)
| geno3=(G;G)
| CEU | 0.9 | 33.0 | 66.1
| HCB | 0.0 | 13.9 | 86.1
| JPT | 0.0 | 3.6 | 96.4
| YRI | 0.0 | 0.0 | 100.0
| ASW | 0.0 | 12.3 | 87.7
| CHB | 0.0 | 13.9 | 86.1
| CHD | 0.0 | 4.7 | 95.3
| GIH | 2.0 | 18.8 | 79.2
| LWK | 0.0 | 0.9 | 99.1
| MEX | 0.0 | 24.1 | 75.9
| MKK | 0.0 | 7.7 | 92.3
| TSI | 5.0 | 50.5 | 44.6
| HapMapRevision=28
}}[[rs891512]] (also known as G24943A, IVS25+15 [G→A]) is an intronic variant in the [[NOS3]] gene significantly associated with blood pressure.

{{PMID|18246059|OA=1
}} The intronic variant, IVS25+15 [G-->A], was significantly associated with blood pressure; GG homozygotes had significantly lower levels of diastolic blood pressure (DBP) (-2.8 mm Hg; P = 0.016) and systolic blood pressure (SBP) (-1.9 mm Hg; P = 0.018) than A-allele carriers.

{{PMID|22425436}} eNOS polymorphism rs891512 (G24943A) is associated with hypertension in Chilean individuals (p<0.05).

{{PMID|17367796|OA=1
}} Two specific SNPs in significant LD with each other (rs891512 and [[rs1808593]]) were significantly associated with ABI (ankle-brachial index) in both subsets.

{{PMID|17579350}} protective haplotype C-T-A ([[rs2070744]]-[[rs1799983]]-rs891512) was observed (P = 0.01) with a pronounced effect against suicide completion (P = 0.005).

{{PMID Auto
|PMID=17605790
|Title=Lack of association between endothelial nitric oxide synthase (NOS3) gene polymorphisms and suicide attempts.
|OA=1
}}

{{PMID Auto
|PMID=18482449
|Title=Investigating the complex genetic architecture of ankle-brachial index, a measure of peripheral arterial disease, in non-Hispanic whites.
|OA=1
}}

{{PMID Auto
|PMID=19493349
|Title=118 SNPs of folate-related genes and risks of spina bifida and conotruncal heart defects.
|OA=1
}}

{{PMID Auto
|PMID=21577011
|Title=NCAM1, TACR1 and NOS genes and temperament: a study on suicide attempters and controls.
}}

{{on chip | 23andMe v3}}
{{on chip | 23andMe v4}}
{{on chip | Affy GenomeWide 6}}
{{on chip | FTDNA2}}
{{on chip | HumanOmni1Quad}}