{{Rsnum
|rsid=908832
|Gene=ABCA2
|Chromosome=9
|position=137018032
|Orientation=plus
|ReferenceAllele=T
|GMAF=0.03765
|Assembly=GRCh38
|GenomeBuild=38.1
|dbSNPBuild=141
|geno1=(A;A)
|geno2=(A;G)
|geno3=(G;G)
|Gene_s=ABCA2
}}This SNP, a synonymous substitution in the [[ABCA2]] gene, has been linked to early onset [[Alzheimer's disease]] with an odds ratio of 3.8 for disease development in carriers of the A allele (in dbSNP orientation) compared to controls (95% CI 2-7.3), based on a study of ~400 Caucasian patients. {{PMID|15649702}}

Subsequently, this association was replicated in a Western European population (n=291, p=0.008), but not in a second sample from Southern Europe. [[rs908832]] was not polymorphic in a Japanese sample. Furthermore, [[rs908832]] was not associated with either serum cholesterol levels or with the risk for coronary artery disease, but did seem to be related to cholesterol levels in the cerebrospinal fluid.{{PMID|16752360}}

{{omim
|desc=ALZHEIMER DISEASE; AD
|id=104300
|rsnum=908832
}}

{{omim
|desc=ATP-BINDING CASSETTE, SUBFAMILY A, MEMBER 2; ABCA2
|id=600047
|rsnum=908832
}}

{{GET Evidence
|gene=ABCA2
|aa_change=Met711Thr
|aa_change_short=M711T
|impact=not reviewed
|qualified_impact=Insufficiently evaluated not reviewed
|inheritance=unknown
|quality_scores=Array
|dbsnp_id=rs908832
|n_genomes=1
|n_genomes_annotated=0
|n_haplomes=2
|n_articles=0
|n_articles_annotated=0
|nblosum100=2
|autoscore=1
|webscore=N
}}

{{on chip | 23andMe v1}}
{{on chip | 23andMe v2}}
{{on chip | 23andMe v3}}
{{on chip | 23andMe v4}}
{{on chip | FTDNA2}}
{{on chip | HumanOmni1Quad}}