{{Rsnum
|rsid=909706
|Gene=DTNBP1
|Chromosome=6
|position=15660640
|Orientation=minus
|GMAF=0.4183
|Assembly=GRCh38
|GenomeBuild=38.1
|dbSNPBuild=141
|geno1=(A;A)
|geno2=(A;G)
|geno3=(G;G)
|Gene_s=DTNBP1
}}{{PMID|19369910|OA=1
}} may be associated with [[haloperidol]] response in treatment-resistant schizophrenic patients

{{PharmGKB
|RSID=rs909706
|Name_s=
|Gene_s=DTNBP1
|Feature=
|Evidence=PubMed ID:19369910
|Annotation=Patients with diplotype ACCCTC/GCCGCC, genotype A/G, or allele A of marker rs909706 have better response to haloperidol (0.007</=P</=0.080) in a study of patients with refractory schizophrenia.
|Drugs=haloperidol
|Drug Classes=
|Diseases=Schizophrenia
|Curation Level=Curated
|PharmGKB Accession ID=PA164727955
}}

{{PMID Auto
|PMID=20598229
|Title=DTNBP1 gene is associated with some symptom factors of schizophrenia in Chinese Han nationality
}}

{{PMID Auto
|PMID=12098102
|Title=Genetic variation in the 6p22.3 gene DTNBP1, the human ortholog of the mouse dysbindin gene, is associated with schizophrenia.
|OA=1
}}

{{PMID Auto
|PMID=15362017
|Title=Association of the DTNBP1 locus with schizophrenia in a U.S. population.
|OA=1
}}

{{PMID Auto
|PMID=16133786
|Title=Untranslated region haplotype in dysbindin gene: analysis in schizophrenia.
}}

{{PMID Auto
|PMID=17033966
|Title=Analysis of high-resolution HapMap of DTNBP1 (Dysbindin) suggests no consistency between reported common variant associations and schizophrenia.
|OA=1
}}

{{PMID Auto
|PMID=17074466
|Title=DTNBP1 genotype influences cognitive decline in schizophrenia.
|OA=1
}}

{{PMID Auto
|PMID=18715757
|Title=Genetic associations with schizophrenia: meta-analyses of 12 candidate genes.
|OA=1
}}

{{PMID Auto
|PMID=19862852
|Title=Association study of DTNBP1 with schizophrenia in a US sample.
|OA=1
}}

{{PMID Auto
|PMID=21295953
|Title=Dystrobrevin-binding protein 1 gene (DTNBP1) variants associated with cerebrospinal fluid homovanillic acid and 5-hydroxyindoleacetic acid concentrations in healthy volunteers.
}}

{{GET Evidence
|impact=pharmacogenetic
|qualified_impact=Insufficiently evaluated pharmacogenetic
|inheritance=unknown
|quality_scores=Array
|dbsnp_id=rs909706
|overall_frequency_n=93
|overall_frequency_d=128
|overall_frequency=0.726562
|n_genomes=49
|n_genomes_annotated=0
|n_haplomes=79
|n_articles=1
|n_articles_annotated=0
|in_pharmgkb=Y
|autoscore=1
|webscore=N
}}

{{on chip | 23andMe v1}}
{{on chip | 23andMe v2}}
{{on chip | 23andMe v3}}
{{on chip | 23andMe v4}}