{{Rsnum
|rsid=917997
|Gene=IL18RAP
|Chromosome=2
|position=102454108
|Orientation=minus
|GMAF=0.2773
|Assembly=GRCh38
|GenomeBuild=38.1
|dbSNPBuild=141
|geno1=(A;A)
|geno2=(A;G)
|geno3=(G;G)
}}{{ population diversity
| geno1=(A;A)
| geno2=(A;G)
| geno3=(G;G)
| CEU | 3.5 | 33.6 | 62.8
| HCB | 22.6 | 49.6 | 27.7
| JPT | 10.6 | 56.6 | 32.7
| YRI | 0.7 | 10.9 | 88.4
| ASW | 0.0 | 8.8 | 91.2
| CHB | 22.6 | 49.6 | 27.7
| CHD | 23.9 | 55.0 | 21.1
| GIH | 17.8 | 51.5 | 30.7
| LWK | 0.0 | 29.1 | 70.9
| MEX | 15.5 | 55.2 | 29.3
| MKK | 3.8 | 29.5 | 66.7
| TSI | 5.9 | 28.4 | 65.7
| HapMapRevision=28
}}

{{omim
|desc=CELIAC DISEASE, SUSCEPTIBILITY TO, 8; CELIAC8
|id=612006
|rsnum=917997
}}

{{omim
|desc=INFLAMMATORY BOWEL DISEASE 1; IBD1
|id=266600
|rsnum=917997
}}

{{omim
|desc=INTERLEUKIN 18 RECEPTOR 1; IL18R1
|id=604494
|rsnum=917997
}}

{{omim
|id=604509
|desc=INTERLEUKIN 18 RECEPTOR ACCESSORY PROTEIN; IL18RAP
|rsnum=917997
}}

{{PMID Auto
|PMID=19693089
|Title=Four novel coeliac disease regions replicated in an association study of a Swedish-Norwegian family cohort
}}

{{PharmGKB
|RSID=rs917997
|Name_s=
|Gene_s=IL18RAP
|Feature=
|Evidence=PubMed ID:18439550
|Annotation=In a case - control study, this variant was shown to be strongly associated with susceptibility to Crohn's Disease and to Ulcerative Colitis.
|Drugs=
|Drug Classes=
|Diseases=Colitis, Ulcerative; Crohn Disease
|Curation Level=Curated
|PharmGKB Accession ID=PA161614198
}}
{{PMID Auto
|PMID=19542083
|Title=Association of IL18RAP and CCR3 with coeliac disease in the Spanish population
}}

{{PMID Auto GWAS
|PMID=20190752
|Trait=Celiac disease
|Title=Multiple common variants for celiac disease influencing immune gene expression
|RiskAllele=A
|Pval=1E-15
|OR=1.19
|ORtxt=[1.14-1.25]
|OA=1
}}

{{omim
|id=212750
|rsnum=917997
}}

{{PMID Auto
|PMID=22664470
|Title=Genes of the Interleukin-18 Pathway Are Associated With Susceptibility to Barrett's Esophagus and Esophageal Adenocarcinoma
}}

{{PMID|18311140|OA=1
}} Newly identified genetic risk variants for celiac disease related to the immune response.

{{PMID|18587394|OA=1
}} Genome-wide association defines more than 30 distinct susceptibility loci for Crohn's disease.

{{PMID|18713140|OA=1
}} Translational mini-review series on the immunogenetics of gut disease: immunogenetics of coeliac disease.

{{PMID|19068216|OA=1
}} Investigation of Crohn's disease risk loci in ulcerative colitis further defines their molecular relationship.

{{PMID|19073967|OA=1
}} Shared and distinct genetic variants in type 1 diabetes and celiac disease.

{{PMID|19103669}} Association study of the IL18RAP locus in three European populations with coeliac disease.

{{PMID|19468064|OA=1
}} Parasites represent a major selective force for interleukin genes and shape the genetic predisposition to autoimmune conditions.

{{PMID|19557189|OA=1
}} Identifying relationships among genomic disease regions: predicting genes at pathogenic SNP associations and rare deletions.

{{PMID|20353565|OA=1
}} Allelic variants of IL1R1 gene associate with severe hand osteoarthritis.

{{PMID|21304977|OA=1
}} An investigation of genome-wide studies reported susceptibility loci for ulcerative colitis shows limited replication in north Indians.

{{GET Evidence
|impact=pharmacogenetic
|qualified_impact=Insufficiently evaluated pharmacogenetic
|inheritance=unknown
|quality_scores=Array
|dbsnp_id=rs917997
|overall_frequency_n=109
|overall_frequency_d=128
|overall_frequency=0.851562
|n_genomes=53
|n_genomes_annotated=0
|n_haplomes=94
|n_articles=1
|n_articles_annotated=0
|in_pharmgkb=Y
|autoscore=1
|webscore=N
}}

{{PMID Auto GWAS
  |PMID=23128233
  |Trait=Inflammatory bowel disease
  |Title=Host-microbe interactions have shaped the genetic architecture of inflammatory bowel disease.
  |RiskAllele=T
  |Pval=3E-20
  |OR=1.10
  |ORtxt=[1.067-1.14]
  |OA=1
}}

{{PMID Auto
|PMID=24871462
|Title=Coeliac disease-associated polymorphisms influence thymic gene expression
}}
{{on chip | 23andMe v1}}
{{on chip | 23andMe v2}}
{{on chip | 23andMe v3}}
{{on chip | 23andMe v4}}
{{on chip | FTDNA2}}
{{on chip | FTDNA}}
{{on chip | HumanOmni1Quad}}
{{on chip | Illumina Human 1M}}